Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
30931891
DOI
10.14712/18059694.2019.40
PII: am_2019062010012
Knihovny.cz E-resources
- Keywords
- disulfide, fibromyalgia, oxidative stress, thiol, thiol/disulfide homeostasis,
- MeSH
- Antioxidants metabolism MeSH
- Biomarkers blood MeSH
- Disulfides blood MeSH
- Adult MeSH
- Fibromyalgia blood physiopathology MeSH
- Homeostasis * MeSH
- Middle Aged MeSH
- Humans MeSH
- Oxidative Stress physiology MeSH
- Cross-Sectional Studies MeSH
- Sulfhydryl Compounds blood MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antioxidants MeSH
- Biomarkers MeSH
- Disulfides MeSH
- Sulfhydryl Compounds MeSH
BACKGROUND: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. MATERIAL AND METHODS: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel's novel methods. RESULTS: Native thiol (330.6 ± 46.1 vs. 356.8 ± 55.5 μmol/L, p = 0.005) and native thiol/total thiol (89.4 ± 3.2 vs. 93.3 ± 4.0, p < 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 ± 6.3 vs. 12.2 ± 6.3 μmol/L, p < 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. CONCLUSIONS: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.
Department of Biochemistry Istanbul Laboratory Istanbul Turkey
Department of Biochemistry Malatya Education and Research Hospital Malatya Turkey
Department of Clinical Biochemistry Ankara Education and Research Hospital Ankara Turkey
Department of Clinical Biochemistry Faculty of Medicine Yildirim Beyazit University Ankara Turkey
Department of Internal Medicine Camlica Erdem Hastanesi Istanbul Turkey
Departments of Orthopedics and Traumatology Antalya Training and Research Hospital Antalya Turkey
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