Cytopathological features of secretory carcinoma of salivary glands and ancillary techniques in its diagnostics: impact of new Milan system for reporting salivary gland cytopathology
Jazyk angličtina Země Dánsko Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
Ministry of Education, Youth and Sports of the Czech Republic
PubMed
30942913
DOI
10.1111/apm.12950
Knihovny.cz E-zdroje
- Klíčová slova
- ETV6, FNA, Milan system, Salivary glands, mammary analog secretory carcinoma, secretory carcinoma,
- MeSH
- cytodiagnostika metody MeSH
- dospělí MeSH
- imunohistochemie metody MeSH
- karcinom diagnóza metabolismus patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nádorové biomarkery metabolismus MeSH
- nádory slinných žláz diagnóza metabolismus patologie MeSH
- protein ETS, translokační varianta 6 MeSH
- proteiny S100 metabolismus MeSH
- protoonkogenní proteiny c-ets metabolismus MeSH
- represorové proteiny metabolismus MeSH
- senioři MeSH
- slinné žlázy metabolismus patologie MeSH
- tenkojehlová biopsie metody MeSH
- vimentin metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- nádorové biomarkery MeSH
- proteiny S100 MeSH
- protoonkogenní proteiny c-ets MeSH
- represorové proteiny MeSH
- vimentin MeSH
Secretory carcinoma (SC) of salivary glands is a newly described low-grade malignancy characterized by the presence of ETV6 rearrangement. Only a few cases and very small series with cytomorphology were reported so far. Six cases of fine-needle aspirations (FNAs) from afterward histologically, immunohistochemically and genetically confirmed SCs were retrieved from the archives of the authors. Ancillary immunocytochemistry (ICC) and translocation detection were performed on cell blocks (CBs). All aspirates were sufficiently cellular and cells were arranged in more or less cohesive groups with only mild nuclear polymorphism. The cytoplasm was eosinophilic, granulated and vacuolated, especially in CBs. Secretory material within the microcystic spaces was periodic acid-Schiff (PAS) positive. Triple positivity of immunomarkers S-100 protein, mammaglobin and vimentin was present. The proliferation index was low. Ancillary techniques suggested the possibility of SC in a few cytology cases; nevertheless, the final diagnosis was based on histomorphology, immunohistochemistry and genetics. The SC of salivary glands is detectable pre-operatively using ICC and genetics. The presence of the diagnostic ETV6 rearrangement increases the accuracy of FNA to the maximum. According to the Milan system, cases genetically not confirmed should be categorized as Suspicious for Malignancy or Salivary Gland Neoplasm of Uncertain Malignant Potential (SUMP), both requiring surgery.
Bioptic Laboratory Ltd Plzeň 2 Slovany Czech Republic
Department of Pathology Faculty of Medicine and Health Technology Tampere University Tampere Finland
Department of Pathology Faculty of Medicine in Plzeň Charles University Plzeň Czech Republic
Department of Pathology Fimlab Laboratories Tampere Finland
Molecular Pathology Laboratory Bioptic Laboratory Ltd Plzeň 2 Slovany Czech Republic
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