Nanodrugs used in cancer therapy
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
30967685
DOI
10.5507/bp.2019.010
Knihovny.cz E-zdroje
- Klíčová slova
- cancer, nanodrugs, nanomedicine, nanotechnology, targeted therapy,
- MeSH
- albuminy MeSH
- lékové transportní systémy MeSH
- lidé MeSH
- liposomy MeSH
- micely MeSH
- nádory farmakoterapie MeSH
- nanotechnologie * MeSH
- protinádorové látky aplikace a dávkování MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- albuminy MeSH
- liposomy MeSH
- micely MeSH
- protinádorové látky MeSH
Cancer despite the introduction of new targeted therapy remains for many patients a fatal disease. Nanotechnology in cancer medicine has emerged as a promising approach to defeat cancer. Targeted delivery of anti-cancer drugs by different nanosystems promises enhanced drug efficacy, selectivity, better safety profile and reduced systemic toxicity. The article presents an overview of recent developments in cancer nanomedicine. We focus on approved anti-cancer medical products and on the results of clinical studies, highlighting that liposomal and micellar cytostatics or albumin-based nanoparticles have less side effects and are more efficient than "free" drugs. In addition, we discuss results of in vitro and in vivo preclinical studies with lipid, inorganic and polymer nanosystems loaded by anticancer drugs which according to our meaning are important for development of new nanodrugs. Pharmacokinetic characteristics of nanodrugs are discussed and characterization of major nanotechnology systems used for cancer nanomedicine is presented.
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