Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
PubMed
30971355
DOI
10.1016/j.tvjl.2019.03.005
PII: S1090-0233(19)30038-3
Knihovny.cz E-resources
- Keywords
- Dog, Mast cell tumour, Mutation, TP53, c-kit,
- MeSH
- Gene Frequency MeSH
- Mastocytosis, Cutaneous genetics pathology veterinary MeSH
- Mutation * MeSH
- Tumor Suppressor Protein p53 genetics MeSH
- Skin Neoplasms genetics pathology veterinary MeSH
- Dog Diseases genetics pathology MeSH
- Prognosis MeSH
- Proto-Oncogene Proteins c-kit genetics MeSH
- Dogs MeSH
- Neoplasm Grading veterinary MeSH
- Animals MeSH
- Check Tag
- Dogs MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Tumor Suppressor Protein p53 MeSH
- Proto-Oncogene Proteins c-kit MeSH
Cutaneous mast cell tumours (MCT) are among the most frequent malignancies in dogs. Their clinical behaviour is highly variable and, with the exception of mutations in the c-kit gene, little is known about their genetic aetiology. The mutational status of the c-kit exons 8, 9 and 11, and exons 5-8 of the TP53 gene was analysed to find markers for molecular stratification of MCTs and predictors of clinical outcome. Mutations in the c-kit gene were detected in 19.5% (n = 8/41) samples and their presence was significantly associated with the high histopathological grade (P = 0.038). Mutations in the DNA binding domain of the TP53 gene were found in 14.6% (n = 6/41) of the analysed MCTs, and their frequency was similar in low and high grade MCTs (P > 0.05). TP53 mutations were not useful prognostic factors in this sample of canine cutaneous MCTs.
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