Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
35203268
PubMed Central
PMC8870669
DOI
10.3390/cells11040618
PII: cells11040618
Knihovny.cz E-zdroje
- Klíčová slova
- cutaneous, dog, mast cell tumor, subcutaneous,
- MeSH
- mastocyty patologie MeSH
- myeloproliferativní poruchy * MeSH
- nádory kůže * diagnóza terapie veterinární MeSH
- nemoci psů * diagnóza terapie MeSH
- psi MeSH
- subkutánní tkáň patologie MeSH
- zvířata MeSH
- Check Tag
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Mast cell tumors (MCTs) are hematopoietic neoplasms composed of mast cells. It is highly common in dogs and is extremely important in the veterinary oncology field. It represents the third most common tumor subtype, and is the most common malignant skin tumor in dogs, corresponding to 11% of skin cancer cases. The objective of this critical review was to present the report of the 2nd Consensus meeting on the Diagnosis, Prognosis, and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors, which was organized by the Brazilian Association of Veterinary Oncology (ABROVET) in August 2021. The most recent information on cutaneous and subcutaneous mast cell tumors in dogs is presented and discussed.
Clinical and Surgical Oncology E Veterinary Specialties São Paulo 04078 012 Brazil
Clinical and Surgical Oncology Vet Cancer Animal Oncology and Pathology São Paulo 04523 013 Brazil
Clinical Oncology and Radiation Therapy Oncopet Veterinary Rio de Janeiro 22631 000 Brazil
Clinical Oncology Onccarevet e Onconnectionvet Ribeirão Preto 14026 587 Brasil
Clinical Surgical and Palliative Care Oncology Onco Cane Veterinary São Paulo 04084 002 Brazil
Department of Veterinary Medicine Universidade Federal do Paraná Curitiba 80035 050 Brazil
Eletro Onkovet Service Franca 14406 005 Brazil
General Pathology Department Dental School Universidade de São Paulo São Paulo 05508 000 Brazil
Institute of Health Sciences Universidade Paulista Bauru 17048 290 Brazil
Institute of Health Sciences Universidade Paulista São Paulo 01533 000 Brazil
Laboratory of Comparative and Translational Oncology Pirassununga 13635 900 Brazil
Naya Specialties Campo Belo 04608 003 Brazil
ONE Patologia Veterinária Santos 11055 051 Brazil
Radiation Oncology Service Pet Care Oncologic Center São Paulo 05659 010 Brazil
School of Veterinary Universidade Federal de Minas Gerais Belo Horizonte 31270 901 Brazil
Surgical and Clinical Oncology Bota Fogo Veterinary Hospital Rio de Janeiro 22281 180 Brazil
Surgical Pathology Vet Câncer LTDA ME São Paulo 04523 013 Brazil
Técnica Cirúrgica da Pontifícia Pontifícia Universidade Católica do Paraná Curitiba 80215 901 Brazil
Veterinary Research Institute 621 00 Brno Czech Republic
Vetschool São Paulo Veterinária Universidade Estadual Paulista São Paulo 03308 010 Brazil
Zobrazit více v PubMed
Macy D.W. Canine Mast Cell Tumors. Vet. Clin. North Am. Small Anim. Pr. 1985;15:783–803. doi: 10.1016/S0195-5616(85)50036-4. PubMed DOI
Pakhrin B., Kang M.-S., Bae I.-H., Park M.-S., Jee H., You M.-H., Kim J.-H., Yoon B.-I., Choi Y.-K., Kim D.-Y. Retrospective study of canine cutaneous tumors in Korea. J. Vet. Sci. 2007;8:229–236. doi: 10.4142/jvs.2007.8.3.229. PubMed DOI PMC
Gamlem H., Nordstoga K., Glattre E. Canine neoplasia—Introductory paper. APMIS. 2008;116:5–18. doi: 10.1111/j.1600-0463.2008.125m2.x. PubMed DOI
Grabarević Ž., Bubić Špoljar J., Gudan Kurilj A., Šoštarić-Zuckermann I.C., Artuković B., Hohšteter M., Beck A., Džaja P., Maltar Strmečki N. Mast cell tumor in dogs–incidence and histopathological characterization. Coll. Antropol. 2009;33:253–258. PubMed
Villamil J.A., Henry C.J., Bryan J.N., Ellersieck M., Schultz L., Tyler J.W., Hahn A.W. Identification of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms. J. Am. Vet. Med. Assoc. 2011;239:960–965. doi: 10.2460/javma.239.7.960. PubMed DOI
Kimura K.C., Gárate A.P., Dagli M.L.Z. Retrospective Study of Neoplasms in Domestic Animals: A Survey Between 1993 and 2002 of the Service of Animal Pathology Department of Pathology School of Veterinary Medicine and Animal Science University of Sao Paulo Southeast Brazil. Braz. J. Vet. Pathol. 2012;5:60–69.
Warland J., Dobson J.M. Breed predispositions in canine mast cell tumour: A single centre experience in the United Kingdom. Vet. J. 2013;197:496–498. doi: 10.1016/j.tvjl.2013.02.017. PubMed DOI
Freeman K., Kirtz G., Hooijberg E.H., Sick K., Leidinger E.F. Breed related odds ratio and anatomic distribution of canine mast cell tumours in Austria. Tierarztl. Prax. Ausg. K. 2014;42:367–373. doi: 10.15654/TPK-140165. PubMed DOI
Shoop-Worrall S., Marlow S., Church D.B., English K., McGreevy P.D., Stell A.J., Thomson P.C., O’Neill D.G., Brodbelt D.C. Prevalence and risk factors for mast cell tumours in dogs in England. Canine Genet. Epidemiol. 2015;2:1–10. doi: 10.1186/2052-6687-2-1. PubMed DOI PMC
Baioni E., Scanziani E., Vincenti M.C., Leschiera M., Bozzetta E., Pezzolato M., Desiato R., Bertolini S., Maurella C., Ru G. Estimating canine cancer incidence: Findings from a population-based tumour registry in northwestern Italy. BMC Vet. Res. 2017;13:1–9. doi: 10.1186/s12917-017-1126-0. PubMed DOI PMC
Horta R.S., LaValle G.E., Monteiro L.N., Souza M.C.C., Cassali G.D., Araújo R.B. Assessment of Canine Mast Cell Tumor Mortality Risk Based on Clinical, Histologic, Immunohistochemical, and Molecular Features. Vet. Pathol. 2018;55:212–223. doi: 10.1177/0300985817747325. PubMed DOI
Graf R., Pospischil A., Guscetti F., Meier D., Welle M., Dettwiler M. Cutaneous Tumors in Swiss Dogs: Retrospective Data From the Swiss Canine Cancer Registry, 2008–2013. Vet. Pathol. 2018;55:809–820. doi: 10.1177/0300985818789466. PubMed DOI
Kok M.K., Chambers J., Tsuboi M., Nishimura R., Tsujimoto H., Uchida K., Nakayama H. Retrospective study of canine cutaneous tumors in Japan, 2008-2017. J. Vet. Med. Sci. 2019;81:1133–1143. doi: 10.1292/jvms.19-0248. PubMed DOI PMC
De Nardi A.B., Costa M.T., Amorim R.L., Vasconcelos R.O., Dagli M.L.Z., Rocha N.S., Neto R.T., Grandi F., Alessi A.C., Magalhães G.M., et al. Brazilian Consensus For The Diagnosis, Treatment And Prognosis Of Cutaneous Mast Cell Tumors In Dogs. Investigação. 2018;17:1–15. doi: 10.26843/investigacao.v17i1.1837. DOI
Thamm D.H. Miscellaneous tumors: Hemangiosarcoma. In: Withrow S.J., Vail D.M., Page R.L., editors. Withrow and MacEwen’s Small Animal Clinical Oncology. 5th ed. Elsevier Saunders; St. Louis, MI, USA: 2013. pp. 679–688.
De Nardi A.B., Rodaski S., Sousa R.S., Costa T.A., Macedo T.R., Rodigheri S.M., Ríos A., Piekarz C.H. Prevalência de neoplasias e modalidades de tratamentos em cães, atendidos no hospital veterinário da Universidade federal do Paraná. Arch. Vet. Sci. 2002;7 doi: 10.5380/avs.v7i2.3977. DOI
De Souza T.M., Fighera R.A., Irigoyen L.F., De Barros C.S.L. Estudo retrospectivo de 761 tumores cutâneos em cães. CiÊNcia Rural. 2006;36:555–560. doi: 10.1590/S0103-84782006000200030. DOI
Meirelles A.E.W.B., Oliveira E.C., Rodrigues B.A., Costa G.R., Sonne L., Tesser E.S., Driemeier D. Prevalência de neoplasmas cutâneos em cães da região metropolitana de Porto Alegre, RS: 1.017 casos (2002–2007) Pesqui. Vet. Bras. 2010;30:968–973. doi: 10.1590/S0100-736X2010001100011. DOI
Kiupel M., Webster J.D., Miller R.A., Kaneene J.B. Impact of Tumour Depth, Tumour Location and Multiple Synchronous Masses on the Prognosis of Canine Cutaneous Mast Cell Tumours. J. Vet. Med. Ser. A. 2005;52:280–286. doi: 10.1111/j.1439-0442.2005.00726.x. PubMed DOI
Murphy S., Sparkes A.H., Blunden A.S., Brearley M.J., Smith K.C. Effects of stage and number of tumours on prognosis of dogs with cutaneous mast cell tumours. Vet. Rec. 2006;158:287–291. doi: 10.1136/vr.158.9.287. PubMed DOI
Mullins M.N., Dernell W.S., Withrow S.J., Ehrhart E.J., Thamm D.H., Lana S.E. Evaluation of prognostic factors associated with outcome in dogs with multiple cutaneous mast cell tumors treated with surgery with and without adjuvant treatment: 54 cases (1998–2004) J. Am. Vet. Med. Assoc. 2006;228:91–95. doi: 10.2460/javma.228.1.91. PubMed DOI
Costa-Casagrande T.A., Elias D.S., Melo S.R., Matera J.M. ESTUDO RETROSPECTIVO DO MASTOCITOMA CANINO NO SERVIÇO DE CIRURGIA DE PEQUENOS ANIMAIS—HOSPITAL VETERINÁRIO DA FACULDADE DE MEDICINA VETERINÁRIA E ZOOTECNIA DA UNIVERSIDADE DE SÃO PAULO. Arch. Vet. Sci. 2008;13 doi: 10.5380/avs.v13i3.11667. DOI
Furlani J.M., Daleck C.R., Vicenti F.A.M., De Nardi A.B., Pereira G.T., Santana Á.E., Eurides D., da Silva L.A.F. Mastocitoma canino: Estudo retrospectivo. CiÊNcia Anim. Bras. 2008;9:242–250.
Mochizuki H., Motsinger-Reif A., Bettini C., Moroff S., Breen M. Association of breed and histopathological grade in canine mast cell tumours. Vet. Comp. Oncol. 2016;15:829–839. doi: 10.1111/vco.12225. PubMed DOI
Śmiech A., Ślaska B., Łopuszyński W., Jasik A., Bochyńska D., Dąbrowski R. Epidemiological assessment of the risk of canine mast cell tumours based on the Kiupel two-grade malignancy classification. Acta Vet. Scand. 2018;60:1–9. doi: 10.1186/s13028-018-0424-2. PubMed DOI PMC
Pierini A., Lubas G., Gori E., Binanti D., Millanta F., Marchetti V. Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy. Vet. Sci. 2019;6:53. doi: 10.3390/vetsci6020053. PubMed DOI PMC
Śmiech A., Łopuszyński W., Ślaska B., Bulak K., Jasik A. Occurrence and distribution of canine cutaneous mast cell tumour characteristics among predisposed breeds. J. Vet. Res. 2019;63:141–148. doi: 10.2478/jvetres-2019-0002. PubMed DOI PMC
London C., Galli S.J., Yuuki T., Hu Z.-Q., Helfand S.C., Geissler E.N. Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit. Exp. Hematol. 1999;27:689–697. doi: 10.1016/S0301-472X(98)00075-7. PubMed DOI
Reguera M.J., Rabanal R.M., Puigdemont A., Ferrer L. Canine Mast Cell Tumors Express Stem Cell Factor Receptor. Am. J. Dermatopathol. 2000;22:49–54. doi: 10.1097/00000372-200002000-00010. PubMed DOI
Zemke D., Yamini B., Yuzbasiyan-Gurkan V. Mutations in the Juxtamembrane Domain of c-KIT Are Associated with Higher Grade Mast Cell Tumors in Dogs. Vet. Pathol. 2002;39:529–535. doi: 10.1354/vp.39-5-529. PubMed DOI
Turin L., Acocella F., Stefanello D., Oseliero A., Fondrini D., Brizzola S., Riva F. Expression of C-Kit Proto-Oncogene in Canine Mastocytoma: A Kinetic Study Using Real-Time Polymerase Chain Reaction. J. Vet. Diagn. Investig. 2006;18:343–349. doi: 10.1177/104063870601800404. PubMed DOI
Webster J.D., Yuzbasiyan-Gurkan V., Miller R.A., Kaneene J.B., Kiupel M. Cellular Proliferation in Canine Cutaneous Mast Cell Tumors: Associations with c-KIT and Its Role in Prognostication. Vet. Pathol. 2007;44:298–308. doi: 10.1354/vp.44-3-298. PubMed DOI
Ma Y., Longley B.J., Wang X., Blount J.L., Langley K., Caughey G.H. Clustering of Activating Mutations in c-KIT’s Juxtamembrane Coding Region in Canine Mast Cell Neoplasms. J. Investig. Dermatol. 1999;112:165–170. doi: 10.1046/j.1523-1747.1999.00488.x. PubMed DOI
Downing S., Chien M.B., Kass P.H., Moore P.F., London C.A. Prevalence and importance of internal tandem duplications in exons 11 and 12 of c- kit in mast cell tumors of dogs. Am. J. Vet. Res. 2002;63:1718–1723. doi: 10.2460/ajvr.2002.63.1718. PubMed DOI
Webster J.D., Kiupel M., Yuzbasiyan-Gurkan V. Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumors. BMC Cancer. 2006;6:85–88. doi: 10.1186/1471-2407-6-85. PubMed DOI PMC
Webster J.D., Yuzbasiyan-Gurkan V., Kaneene J.B., Miller R., Resau J.H., Kiupel M. The Role of c-KIT in Tumorigenesis: Evaluation in Canine Cutaneous Mast Cell Tumors. Neoplasia. 2006;8:104–111. doi: 10.1593/neo.05622. PubMed DOI PMC
Letard S., Yang Y., Hanssens K., Palmérini F., Leventhal P.S., Guéry S., Moussy A., Kinet J.-P., Hermine O., Dubreuil P. Gain-of-Function Mutations in the Extracellular Domain of KIT Are Common in Canine Mast Cell Tumors. Mol. Cancer Res. 2008;6:1137–1145. doi: 10.1158/1541-7786.MCR-08-0067. PubMed DOI
London C.A., Malpas P.B., Wood-Follis S.L., Boucher J.F., Rusk A.W., Rosenberg M.P., Henry C.J., Mitchener K.L., Klein M.K., Hintermeister J.G., et al. Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or Distant) Mast Cell Tumor Following Surgical Excision. Clin. Cancer Res. 2009;15:3856–3865. doi: 10.1158/1078-0432.CCR-08-1860. PubMed DOI
Takeuchi Y., Fujino Y., Watanabe M., Takahashi M., Nakagawa T., Takeuchi A., Bonkobara M., Kobayashi T., Ohno K., Uchida K., et al. Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours: A retrospective cohort study. Vet. J. 2013;196:492–498. doi: 10.1016/j.tvjl.2012.11.018. PubMed DOI
Tamlin V.S., Bottema C.D.K., Peaston A.E. Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment. Vet. Med. Sci. 2019;6:3–18. doi: 10.1002/vms3.201. PubMed DOI PMC
Vozdova M., Kubickova S., Fictum P., Fröhlich J., Jelinek F., Rubes J. Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours. Vet. J. 2019;247:71–74. doi: 10.1016/j.tvjl.2019.03.005. PubMed DOI
Brocks B.A.W., Bertram C.A., Bartel A., Kirpensteijn J., Collins-Webb A., Catlin C., Thaiwong T., Kiupel M. Internal Tandem Duplication of Exon 8 of c-kit Is Associated With Longer Total Survival in Canine Cutaneous Mast Cell Tumors. Vet. Pathol. 2020;58:315–324. doi: 10.1177/0300985820973463. PubMed DOI
Kanaya N., Okuda M., Toyama N., Oikawa T., Inokuma H., Morimoto M., Hayashi T., Une S., Nakaichi M., Taura Y., et al. Detection of the Anti-P53 Antibodies in Dogs with Tumors. J. Vet. Med. Sci. 2002;64:973–979. doi: 10.1292/jvms.64.973. PubMed DOI
Zorzan E., Hanssens K., Giantin M., Dacasto M., Dubreuil P. Mutational Hotspot of TET2, IDH1, IDH2, SRSF2, SF3B1, KRAS, and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast Cell Tumors. PLoS ONE. 2015;10:e0142450. doi: 10.1371/journal.pone.0142450. PubMed DOI PMC
Yoda A., Adelmant G., Tamburini J., Chapuy B., Shindoh N., Yoda Y., Weigert O., Kopp N., Wu S.-C., Kim S.S., et al. Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. Nat. Med. 2014;21:71–75. doi: 10.1038/nm.3751. PubMed DOI PMC
Mochizuki H., Thomas R., Moroff S., Breen M. Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade. Chromosom. Res. 2017;25:129–143. doi: 10.1007/s10577-016-9543-7. PubMed DOI
Jark P.C., Mundin D.B., de Carvalho M., Ferioli R.B., Anai L.A., Marchi F.A., Rogatto S.R., Laufer-Amorim R., Tinucci-Costa M. Genomic copy number variation associated with clinical outcome in canine cutaneous mast cell tumors. Res. Vet. Sci. 2017;111:26–30. doi: 10.1016/j.rvsc.2016.11.009. PubMed DOI
Patnaik A.K., Ehler W.J., MacEwen E.G. Canine Cutaneous Mast Cell Tumor: Morphologic Grading and Survival Time in 83 Dogs. Vet. Pathol. 1984;21:469–474. doi: 10.1177/030098588402100503. PubMed DOI
Bostock D. Neoplasms of the skin and subcutaneous tissues in dogs and cats. Br. Vet. J. 1986;142:1–19. doi: 10.1016/0007-1935(86)90002-3. PubMed DOI
Weisse C., Shofer F.S., Sorenmo K. Recurrence Rates and Sites for Grade II Canine Cutaneous Mast Cell Tumors Following Complete Surgical Excision. J. Am. Anim. Hosp. Assoc. 2002;38:71–73. doi: 10.5326/0380071. PubMed DOI
Hume C.T., Kiupel M., Rigatti L., Shofer F.S., Skorupski K.A., Sorenmo K.U. Outcomes of Dogs with Grade 3 Mast Cell Tumors: 43 Cases (1997–2007) J. Am. Anim. Hosp. Assoc. 2011;47:37–44. doi: 10.5326/JAAHA-MS-5557. PubMed DOI
Daleck C.R., De Nardi A.B. Oncologia em cães e gatos. Volume 2. Grupo Gen-Editora Roca Ltda; Rio de Janeiro, Brazil: 2016. pp. 971–995.
O’Connell K., Thomson M. Evaluation of prognostic indicators in dogs with multiple, simultaneously occurring cutaneous mast cell tumours: 63 cases. Vet. Comp. Oncol. 2011;11:51–62. doi: 10.1111/j.1476-5829.2011.00301.x. PubMed DOI
Berlato D., Bulman-Fleming J., Clifford C.A., Garrett L., Intile J., Jones P., Kamstock D.A., Liptak J.M., Pavuk A., Powell R., et al. Value, Limitations, and Recommendations for Grading of Canine Cutaneous Mast Cell Tumors: A Consensus of the Oncology-Pathology Working Group. Vet. Pathol. 2021;58:858–863. doi: 10.1177/03009858211009785. PubMed DOI
Moore A.S., Frimberger A.E., Taylor D., Sullivan N. Retrospective outcome evaluation for dogs with surgically excised, solitary Kiupel high-grade, cutaneous mast cell tumours. Vet. Comp. Oncol. 2020;18:402–408. doi: 10.1111/vco.12565. PubMed DOI
Willmann M., Yuzbasiyan-Gurkan V., Marconato L., Dacasto M., Hadzijusufovic E., Hermine O., Sadovnik I., Gamperl S., Schneeweiss-Gleixner M., Gleixner K.V., et al. Proposed Diagnostic Criteria and Classification of Canine Mast Cell Neoplasms: A Consensus Proposal. Front. Vet. Sci. 2021;8 doi: 10.3389/fvets.2021.755258. PubMed DOI PMC
Macy D., Tams T. Canine Mast Cell Tumors. Vet. Clin. North Am. Small Anim. Pract. 1981;3:869–877. doi: 10.1016/S0195-5616(85)50036-4. PubMed DOI
Turrel J.M., Kitchell B.E., Miller L.M., Théon A. Prognostic factors for radiation treatment of mast cell tumor in 85 dogs. J. Am. Vet. Med. Assoc. 1988;193 PubMed
Fox L.E. Mast Cell Tumors. In: Morrison W.B., editor. Cancer in Dogs and Cats Medical and Surgical Management. Linppincott Williams & Wilkins; Philadelphia, PA, USA: 1998. pp. 479–488.
Nelson R., Couto C.G. Medicina interna de pequenos animais. Elsevier; Centro Rio de Janeiro, Brazil: 2015.
Sfiligoi G., Rassnick K.M., Scarlett J.M., Northrup N.C., Gieger T.L. Outcome of Dogs with Mast Cell Tumors in the Inguinal or Perineal Region Versus Other Cutaneous Locations: 124 Cases (1990–2001) J. Am. Vet. Med. Assoc. 2005;226:1368–1374. doi: 10.2460/javma.2005.226.1368. PubMed DOI
Hillman L.A., Garrett L.D., De Lorimier L.-P., Charney S.C., Borst L., Fan T.M. Biological behavior of oral and perioral mast cell tumors in dogs: 44 cases (1996–2006) J. Am. Vet. Med. Assoc. 2010;237:936–942. doi: 10.2460/javma.237.8.936. PubMed DOI
Stockham S.L., Basel D.L., Schmidt D.A. Mastocytemia in Dogs With Acute Inflammatory Diseases. Vet. Clin. Pathol. 1986;15:16–21. doi: 10.1111/j.1939-165X.1986.tb00862.x. PubMed DOI
Hikasa Y., Morita T., Futaoka Y., Sato K., Shimada A., Kagota K., Matsuda H. Connective Tissue-Type Mast Cell Leukemia in a Dog. J. Vet. Med. Sci. 2000;62:187–190. doi: 10.1292/jvms.62.187. PubMed DOI
Plier M.L., MacWilliams P.L. Schalm’s Veterinary Hematology. Vol. 5. Lippincott Williams & Wilkins; Philadelphia, PA, USA: 2000. pp. 747–754.
Welle M.M., Bley C.R., Howard J., Rüfenacht S. Canine mast cell tumours: A review of the pathogenesis, clinical features, pathology and treatment. Vet. Dermatol. 2008;19:321–339. doi: 10.1111/j.1365-3164.2008.00694.x. PubMed DOI
Blackwood L., Murphy S., Buracco P., De Vos J.P., De Fornel-Thibaud P., Hirschberger J., Kessler M., Pastor J., Ponce F., Savary-Bataille K., et al. European consensus document on mast cell tumours in dogs and cats. Vet. Comp. Oncol. 2012;10:e1–e29. doi: 10.1111/j.1476-5829.2012.00341.x. PubMed DOI
Takahashi T., Kadosawa T., Nagase M., Matsunaga S., Mochizuki M., Nishimura R., Sasaki N. Visceral mast cell tumors in dogs: 10 cases (1982-1997) J. Am. Vet. Med. Assoc. 2000;216:222–226. doi: 10.2460/javma.2000.216.222. PubMed DOI
Endicott M.M., Charney S.C., McKnight J.A., Loar A.S., Barger A.M., Bergman P.J. Clinicopathological findings and results of bone marrow aspiration in dogs with cutaneous mast cell tumours: 157 cases (1999?2002) Vet. Comp. Oncol. 2007;5:31–37. doi: 10.1111/j.1476-5829.2006.00115.x. PubMed DOI
Musser M., Berger E., Flaherty H.A., Fox L., Johannes C.M. Marked paraneoplastic hypereosinophilia associated with a low-grade, metastatic canine mast cell tumour. Vet. Rec. Case Rep. 2018;6:e000563. doi: 10.1136/vetreccr-2017-000563. DOI
Cifuentes-Arias S., Osorio-Morales L., Pedraza-Ordóñez F. Clinical follow-up of canine mast cell tumour cases diagnosed by cytology and histopathology. Vet. Stanica. 2021;52:397–403. doi: 10.46419/vs.52.4.1. DOI
Cowell R.L., Tyler R.D., Meinkoth J.H., DeNicola D.B. Diagnóstico citológico e hematologia de cães e gatos. Medvet. São Paulo. 2009:68–77.
De Strefezzi R.F., Xavier J.G., Kleeb S.R., Catão-Dias J.L. Nuclear Morphometry in Cytopathology: A Prognostic Indicator for Canine Cutaneous Mast Cell Tumors. J. Vet. Diagn. Investig. 2009;21:821–825. doi: 10.1177/104063870902100608. PubMed DOI
MacNeill A.L. Cytology of Canine and Feline Cutaneous and Subcutaneous Lesions and Lymph Nodes. Top. Companion Anim. Med. 2011;26:62–76. doi: 10.1053/j.tcam.2011.02.004. PubMed DOI
Grandi F., Beserra H.E.O., Costa L.D. Citopatologia veterinária diagnóstica. São Paulo: Medvet. 2014:80–90.
Camus M.S., Priest H.L., Koehler J.W., Driskell E.A., Rakich P.M., Ilha M.R., Krimer P.M. Cytologic Criteria for Mast Cell Tumor Grading in Dogs With Evaluation of Clinical Outcome. Vet. Pathol. 2016;53:1117–1123. doi: 10.1177/0300985816638721. PubMed DOI
Hergt F., Von Bomhard W., Kent M., Hirschberger J. Use of a 2-tier histologic grading system for canine cutaneous mast cell tumors on cytology specimens. Vet. Clin. Pathol. 2016;45:477–483. doi: 10.1111/vcp.12387. PubMed DOI
Bostock D.E. The prognosis following surgical removal of mastocytomas in dogs. J. Small Anim. Pr. 1973;14:27–40. doi: 10.1111/j.1748-5827.1973.tb06891.x. PubMed DOI
Preziosi R., Morini M., Sarli G. Expression of the KIT Protein (CD117) in Primary Cutaneous Mast Cell Tumors of the Dog. J. Vet. Diagn. Investig. 2004;16:554–561. doi: 10.1177/104063870401600610. PubMed DOI
Kiupel M., Webster J.D., Bailey K.L., Best S., DeLay J., Detrisac C.J., Fitzgerald S.D., Gamble D., Ginn P.E., Goldschmidt M.H., et al. Proposal of a 2-Tier Histologic Grading System for Canine Cutaneous Mast Cell Tumors to More Accurately Predict Biological Behavior. Vet. Pathol. 2010;48:147–155. doi: 10.1177/0300985810386469. PubMed DOI PMC
Thompson J.J., Pearl D.L., Yager J.A., Best S.J., Coomber B.L., Foster R.A. Canine Subcutaneous Mast Cell Tumor. Vet. Pathol. 2010;48:156–168. doi: 10.1177/0300985810387446. PubMed DOI
Fulcher R.P., Ludwig L.L., Bergman P.J., Newman S.J., Simpson A.M., Patnaik A.K. Evaluation of a two-centimeter lateral surgical margin for excision of grade I and grade II cutaneous mast cell tumors in dogs. J. Am. Vet. Med. Assoc. 2006;228:210–215. doi: 10.2460/javma.228.2.210. PubMed DOI
Kamstock D.A., Ehrhart E.J., Getzy D.M., Bacon N.J., Rassnick K.M., Moroff S.D., Liu S.M., Straw R.C., McKnight C.A., Amorim R.L., et al. Recommended Guidelines for Submission, Trimming, Margin Evaluation, and Reporting of Tumor Biopsy Specimens in Veterinary Surgical Pathology. Vet. Pathol. 2010;48:19–31. doi: 10.1177/0300985810389316. PubMed DOI
Thompson J.J., Yager J.A., Best S.J., Pearl D.L., Coomber B.L., Torres R.N., Kiupel M., Foster R.A. Canine Subcutaneous Mast Cell Tumors. Vet. Pathol. 2010;48:169–181. doi: 10.1177/0300985810390716. PubMed DOI
Scarpa F., Sabattini S., Marconato L., Capitani O., Morini M., Bettini G. Use of histologic margin evaluation to predict recurrence of cutaneous malignant tumors in dogs and cats after surgical excision. J. Am. Vet. Med. Assoc. 2012;240:1181–1187. doi: 10.2460/javma.240.10.1181. PubMed DOI
Sledge D.G., Webster J., Kiupel M. Canine cutaneous mast cell tumors: A combined clinical and pathologic approach to diagnosis, prognosis, and treatment selection. Vet. J. 2016;215:43–54. doi: 10.1016/j.tvjl.2016.06.003. PubMed DOI
Strefezzi R.D.F., Xavier J.G., Catão-Dias J.L. Morphometry of Canine Cutaneous Mast Cell Tumors. Vet. Pathol. 2003;40:268–275. doi: 10.1354/vp.40-3-268. PubMed DOI
Northrup N.C., Howerth E.W., Harmon B.G., Brown C.A., Carmicheal K.P., Garcia A.P., Latimer K.S., Munday J.S., Rakich P.M., Richey L.J., et al. Variation among Pathologists in the Histologic Grading of Canine Cutaneous Mast Cell Tumors with Uniform Use of a Single Grading Reference. J. Vet. Diagn. Investig. 2005;17:561–564. doi: 10.1177/104063870501700606. PubMed DOI
Pinczowski P., Torres-Neto R., Fabris V.E., Laufer-Amorim R. Mastocitoma cutâneo canino: Variação da graduação histopatológica entre patologistas. ClÍNica VeterinÁRia. 2008;77:76–78.
Shaw T., Kudnig S.T., Firestone S.M. Diagnostic accuracy of pre-treatment biopsy for grading cutaneous mast cell tumours in dogs. Vet. Comp. Oncol. 2017;16:214–219. doi: 10.1111/vco.12346. PubMed DOI
Meuten D.J., editor. Tumors in Domestic Animals. John Wiley & Sons; Hoboken, NJ, USA: 2020. p. 1008.
Romansik E.M., Reilly C.M., Kass P.H., Moore P.F., London C.A. Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors. Vet. Pathol. 2007;44:335–341. doi: 10.1354/vp.44-3-335. PubMed DOI
Elston L.B., Sueiro F.A., Cavalcanti J.N., Metze K. Letter to the Editor: The Importance of the Mitotic Index as a Prognostic Factor for Survival of Canine Cutaneous Mast Cell Tumors: A Validation Study. Vet. Pathol. 2009;46:362–364. doi: 10.1354/vp.46-2-362. PubMed DOI
Bertram C.A., Aubreville M., Gurtner C., Bartel A., Corner S.M., Dettwiler M., Kershaw O., Noland E.L., Schmidt A., Sledge D.G., et al. Computerized Calculation of Mitotic Count Distribution in Canine Cutaneous Mast Cell Tumor Sections: Mitotic Count Is Area Dependent. Vet. Pathol. 2019;57:214–226. doi: 10.1177/0300985819890686. PubMed DOI
Bertram C.A., Aubreville M., Donovan T.A., Bartel A., Wilm F., Marzahl C., Assenmacher C.-A., Becker K., Bennett M., Corner S., et al. Computer-assisted mitotic count using a deep learning–based algorithm improves interobserver reproducibility and accuracy. Vet. Pathol. 2021 doi: 10.1177/03009858211067478. PubMed DOI PMC
Newman S., Mrkonjich L., Walker K., Rohrbach B. Canine Subcutaneous Mast Cell Tumour: Diagnosis and Prognosis. J. Comp. Pathol. 2007;136:231–239. doi: 10.1016/j.jcpa.2007.02.003. PubMed DOI
Gill V., Leibman N., Monette S., Craft D.M., Bergman P.J. Prognostic Indicators and Clinical Outcome in Dogs with Subcutaneous Mast Cell Tumors Treated with Surgery Alone: 43 Cases. J. Am. Anim. Hosp. Assoc. 2020;56:215–225. doi: 10.5326/JAAHA-MS-6960. PubMed DOI
Weishaar K., Thamm D., Worley D., Kamstock D. Correlation of Nodal Mast Cells with Clinical Outcome in Dogs with Mast Cell Tumour and a Proposed Classification System for the Evaluation of Node Metastasis. J. Comp. Pathol. 2014;151:329–338. doi: 10.1016/j.jcpa.2014.07.004. PubMed DOI
Simoes J.P.C., Schoning P. Canine Mast Cell Tumors: A Comparison of Staining Techniques. J. Vet. Diagn. Investig. 1994;6:458–465. doi: 10.1177/104063879400600410. PubMed DOI
Hashmi A.A., Riaz R., Zia S., Shahid H., Malik U.A., Khan R., Irfan M., Shamail F., Zia F., Asif M.G. Impact of Histological Type and Grade on the Diagnostic Accuracy of Intraoperative Frozen Section for Detecting Breast Cancer Metastasis to Axillary Sentinel Lymph Nodes. Cureus. 2021;13 doi: 10.7759/cureus.16146. PubMed DOI PMC
Kaneko H., Deguchi M., Yano H. Submandibular lymph node metastasis of occult thyroid carcinoma first suspected to be a salivary gland tumor: A case report. J. Med. Case Rep. 2021;15:1–6. doi: 10.1186/s13256-021-02901-7. PubMed DOI PMC
Stern A. Frozen sections compared with paraffin-embedded sections: A retrospective veterinary autopsy study. Braz. J. Vet. Pathol. 2020;13 doi: 10.24070/bjvp.1983-0246.v13i1p12-16. DOI
Whitehair J.G., Griffey S.M., Olander H.J., Vasseur P.B., Naydan D. The Accuracy of Intraoperative Diagnoses Based on Examination of Frozen Sections A Prospective Comparison with Paraffin-Embedded Sections. Vet. Surg. 1993;22:255–259. doi: 10.1111/j.1532-950X.1993.tb00394.x. PubMed DOI
Puebla-Osorio N., Sarchio S.N.E., Ullrich S.E., Byrne S.N. Detection of Infiltrating Mast Cells Using a Modified Toluidine Blue Staining. Methods Mol. Biol. 2017;1627:213–222. doi: 10.1007/978-1-4939-7113-8_14. PubMed DOI
Abadie J.J., Amardeilh M.A., Delverdier M. Immunohistochemical detection of proliferating cell nuclear antigen and Ki-67 in mast cell tumors from dogs. J. Am. Vet. Med. Assoc. 1999;215 PubMed
Kiupel M., Webster J.D., Kaneene J.B., Miller R., Yuzbasiyan-Gurkan V. The Use of KIT and Tryptase Expression Patterns as Prognostic Tools for Canine Cutaneous Mast Cell Tumors. Vet. Pathol. 2004;41:371–377. doi: 10.1354/vp.41-4-371. PubMed DOI
Scase T.J., Edwards D., Miller J., Henley W., Smith K., Blunden A., Murphy S. Canine mast cell tumors: Correlation of apoptosis and proliferation markers with prognosis. J. Vet. Intern. Med. 2006;20:151–158. doi: 10.1111/j.1939-1676.2006.tb02835.x. PubMed DOI
Maglennon G.A., Murphy S., Adams V., Miller J., Smith K., Blunden A., Scase T.J. Association of Ki67 index with prognosis for intermediate-grade canine cutaneous mast cell tumours*. Vet. Comp. Oncol. 2008;6:268–274. doi: 10.1111/j.1476-5829.2008.00168.x. PubMed DOI
Strefezzi R.D.F., Kleeb S.R., Xavier J.G., Dias J.L.C. Avaliação da proliferação celular como indicador prognóstico para mastocitomas cutâneos caninos. Pesq. Vet. Bras. 2010;30:559–565. doi: 10.1590/S0100-736X2010000700009. DOI
Fonseca-Alves C.E., Palmieri C., Dagli M.L.Z., Laufer-Amorim R. Editorial: Precision Medicine in Veterinary Oncology. Front. Vet. Sci. 2021;8 doi: 10.3389/fvets.2021.718891. PubMed DOI PMC
Thompson J.J., Morrison J.A., Pearl D.L., Boston S.E., Wood G., Foster R.A., Coomber B.L. Receptor Tyrosine Kinase Expression Profiles in Canine Cutaneous and Subcutaneous Mast Cell Tumors. Vet. Pathol. 2015;53:545–558. doi: 10.1177/0300985815610388. PubMed DOI
Thamm D.H., Weishaar K.M., Charles J.B., Ehrhart E.J. Phosphorylated KIT as a predictor of outcome in canine mast cell tumours treated with toceranib phosphate or vinblastine. Vet. Comp. Oncol. 2019;18:169–175. doi: 10.1111/vco.12525. PubMed DOI
Smith J., Kiupel M., Farrelly J., Cohen R., Olmsted G., Kirpensteijn J., Brocks B., Post G. Recurrence rates and clinical outcome for dogs with grade II mast cell tumours with a low AgNOR count and Ki67 index treated with surgery alone. Vet. Comp. Oncol. 2015;15:36–45. doi: 10.1111/vco.12140. PubMed DOI
Longley B., Reguera M.J., Ma Y. Classes of c-KIT activating mutations: Proposed mechanisms of action and implications for disease classification and therapy. Leuk. Res. 2001;25:571–576. doi: 10.1016/S0145-2126(01)00028-5. PubMed DOI
Yamada O., Kobayashi M., Sugisaki O., Ishii N., Ito K., Kuroki S., Sasaki Y., Isotani M., Ono K., Washizu T., et al. Imatinib elicited a favorable response in a dog with a mast cell tumor carrying a c-kit c.1523A>T mutation via suppression of constitutive KIT activation. Vet. Immunol. Immunopathol. 2011;142:101–106. doi: 10.1016/j.vetimm.2011.04.002. PubMed DOI
Reguera M.J., Ferrer L., Rabanal R.M. Evaluation of an intron deletion in the c-kit gene of canine mast cell tumors. Am. J. Vet. Res. 2002;63:1257–1261. doi: 10.2460/ajvr.2002.63.1257. PubMed DOI
Cameron L.R.J., Grahn R.A., Chien M.B., Lyons L.A., London C.A. Detection of c-kit Mutations in Canine Mast Cell Tumors using Fluorescent Polyacrylamide Gel Electrophoresis. J. Vet. Diagn. Investig. 2004;16:95–100. doi: 10.1177/104063870401600201. PubMed DOI
Riva F., Brizzola S., Stefanello D., Crema S., Turin L. A Study of Mutations in the c-kit Gene of 32 Dogs with Mastocytoma. J. Vet. Diagn. Investig. 2005;17:385–388. doi: 10.1177/104063870501700416. PubMed DOI
Ohmori K., Kawarai S., Yasuda N., Tanaka A., Matsuda H., Nishimura R., Sasaki N., Tsujimoto H., Masuda K. Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells. Vet. Immunol. Immunopathol. 2008;126:43–53. doi: 10.1016/j.vetimm.2008.06.014. PubMed DOI
Avery A.C. Molecular Diagnostics of Hematologic Malignancies in Small Animals. Vet. Clin. North Am. Small Anim. Pr. 2012;42:97–110. doi: 10.1016/j.cvsm.2011.11.001. PubMed DOI
Book A.P., Fidel J., Wills T., Bryan J., Sellon R., Mattoon J. CORRELATION OF ULTRASOUND FINDINGS, LIVER AND SPLEEN CYTOLOGY, AND PROGNOSIS IN THE CLINICAL STAGING OF HIGH METASTATIC RISK CANINE MAST CELL TUMORS. Vet. Radiol. Ultrasound. 2011;52:548–554. doi: 10.1111/j.1740-8261.2011.01839.x. PubMed DOI
Warland J., Amores-Fuster I., Newbury W., Brearley M., Dobson J.M. The utility of staging in canine mast cell tumours. Vet. Comp. Oncol. 2012;12:287–298. doi: 10.1111/vco.12012. PubMed DOI
Hughes J.R., Szladovits B., Drees R. Abdominal CT evaluation of the liver and spleen for staging mast cell tumors in dogs yields nonspecific results. Vet. Radiol. Ultrasound. 2019;60:306–315. doi: 10.1111/vru.12717. PubMed DOI
Tuohy J.L., Milgram J., Worley D.R., Dernell W.S. A review of sentinel lymph node evaluation and the need for its incorporation into veterinary oncology. Vet. Comp. Oncol. 2009;7:81–91. doi: 10.1111/j.1476-5829.2009.00183.x. PubMed DOI
Krick E.L., Billings A.P., Shofer F.S., Watanabe S., Sorenmo K.U. Cytological lymph node evaluation in dogs with mast cell tumours: Association with grade and survival*. Vet. Comp. Oncol. 2009;7:130–138. doi: 10.1111/j.1476-5829.2009.00185.x. PubMed DOI
Ku C., Kass P.H., Christopher M.M. Cytologic-histologic concordance in the diagnosis of neoplasia in canine and feline lymph nodes: A retrospective study of 367 cases. Vet. Comp. Oncol. 2016;15:1206–1217. doi: 10.1111/vco.12256. PubMed DOI
Ferrari R., Marconato L., Buracco P., Boracchi P., Giudice C., Iussich S., Grieco V., Chiti L.E., Favretto E., Stefanello D. The impact of extirpation of non-palpable/normal-sized regional lymph nodes on staging of canine cutaneous mast cell tumours: A multicentric retrospective study. Vet. Comp. Oncol. 2018;16:505–510. doi: 10.1111/vco.12408. PubMed DOI
Worley D.R. Incorporation of sentinel lymph node mapping in dogs with mast cell tumours: 20 consecutive procedures. Vet. Comp. Oncol. 2012;12:215–226. doi: 10.1111/j.1476-5829.2012.00354.x. PubMed DOI
Lapsley J., Hayes G.M., Janvier V., Newman A.W., Peters-Kennedy J., Balkman C., Sumner J.P., Johnson P. Influence of locoregional lymph node aspiration cytology vs sentinel lymph node mapping and biopsy on disease stage assignment in dogs with integumentary mast cell tumors. Vet. Surg. 2020;50:133–141. doi: 10.1111/vsu.13537. PubMed DOI
Fournier Q., Thierry F., Longo M., Malbon A., Cazzini P., Bisson J., Woods S., Liuti T., Bavcar S. Contrast-enhanced ultrasound for sentinel lymph node mapping in the routine staging of canine mast cell tumours: A feasibility study. Vet. Comp. Oncol. 2020;19:451–462. doi: 10.1111/vco.12647. PubMed DOI
Stefanello D., Buracco P., Sabattini S., Finotello R., Giudice C., Grieco V., Iussich S., Tursi M., Scase T., Di Palma S., et al. Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009–2014) J. Am. Vet. Med. Assoc. 2015;246:765–769. doi: 10.2460/javma.246.7.765. PubMed DOI
London C.A., Seguin B. Mast cell tumors in the dog. Vet. Clin. N. Am. Small Anim. Pract. 2003;33:473–489. doi: 10.1016/S0195-5616(03)00003-2. PubMed DOI
Ozaki K., Yamagami T., Nomura K., Narama I. Prognostic Significance of Surgical Margin, Ki-67 and Cyclin D1 Protein Expression in Grade II Canine Cutaneous Mast Cell Tumor. J. Vet. Med. Sci. 2007;69:1117–1121. doi: 10.1292/jvms.69.1117. PubMed DOI
Hahn K.A., King G.K., Carreras J.K. Efficacy of radiation therapy for incompletely resected grade-III mast cell tumors in dogs: 31 cases (1987–1998) J. Am. Vet. Med. Assoc. 2004;224:79–82. doi: 10.2460/javma.2004.224.79. PubMed DOI
Hayes A., Adams V., Smith K., Maglennon G., Murphy S. Vinblastine and prednisolone chemotherapy for surgically excised grade III canine cutaneous mast cell tumours. Vet. Comp. Oncol. 2007;5:168–176. doi: 10.1111/j.1476-5829.2007.00135.x. PubMed DOI
Pizzoni S., Sabattini S., Stefanello D., Dentini A., Ferrari R., Dacasto M., Giantin M., LaGanga P., Amati M., Tortorella G., et al. Features and prognostic impact of distant metastases in 45 dogs with de novo stage IV cutaneous mast cell tumours: A prospective study. Vet. Comp. Oncol. 2017;16:28–36. doi: 10.1111/vco.12306. PubMed DOI
Jaffe M.H., Hosgood G., Taylor H.W., Kerwin S.C., Hedlund C.S., Lopez M.K., Davidson J.R., Miller D.M., Paranjpe M. Immunohistochemical and Clinical Evaluation of p53 in Canine Cutaneous Mast Cell Tumors. Vet. Pathol. 2000;37:40–46. doi: 10.1354/vp.37-1-40. PubMed DOI
Cruz V.S., Borges J.C.A., Nepomuceno L.L., Gonçalves P.A.M., Prado Y.C.L., Bianchi C., Fioravanti M.C.S., Araújo E.G. Histological classification and expression of markers of canine mast cell tumors. Vet. World. 2020;13:1627–1637. doi: 10.14202/vetworld.2020.1627-1634. PubMed DOI PMC
Webster J.D., Yuzbasiyan-Gurkan V., Thamm D.H., Hamilton E., Kiupel M. Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone. BMC Vet. Res. 2008;4:32. doi: 10.1186/1746-6148-4-32. PubMed DOI PMC
Vascellari M., Giantin M., Capello K., Carminato A., Morello E.M., Vercelli A., Granato A., Buracco P., Dacasto M., Mutinelli F. Expression of Ki67, BCL-2, and COX-2 in Canine Cutaneous Mast Cell Tumors. Vet. Pathol. 2012;50:110–121. doi: 10.1177/0300985812447829. PubMed DOI
Casagrande T.A.C., Barros L.M.D.O., Fukumasu H., Cogliati B., Chaible L.M., Dagli M.L.Z., Matera J.M. The value of molecular expression of KIT and KIT ligand analysed using real-time polymerase chain reaction and immunohistochemistry as a prognostic indicator for canine cutaneous mast cell tumours. Vet. Comp. Oncol. 2013;13:1–10. doi: 10.1111/vco.12010. PubMed DOI
Fonseca-Alves C.E., Bento D.D., Torres-Neto R., Werner J., Kitchell B., Laufer-Amorim R. Ki67/KIT double immunohistochemical staining in cutaneous mast cell tumors from Boxer dogs. Res. Vet. Sci. 2015;102:122–126. doi: 10.1016/j.rvsc.2015.08.007. PubMed DOI
Bergman P.J., Craft D.M., Newman S.J., Baer K., Camps-Palau M.A., McKnight J.A., Leibman N.F., Brenn S., Finora K., Hohenhaus A.E., et al. Correlation of histologic grading of canine mast cell tumors with Ki67/PCNA/AgNOR/c-Kit scores: 38 cases (2002-2003) Vet. Comp. Oncol. 2004;2:98. doi: 10.1111/j.1476-5810.2004.0045a.x. DOI
Barra C.N., Macedo B.M., Cadrobbi K.G., Pulz L.H., Huete G.C., Kleeb S.R., Xavier J.G., Catão-Dias J.L., Nishiya A.T., Fukumasu H., et al. Apoptotic intrinsic pathway proteins predict survival in canine cutaneous mast cell tumours. Vet. Comp. Oncol. 2017;16:E38–E44. doi: 10.1111/vco.12330. PubMed DOI
Melo S.R., Januário E.V., Zanuto E., De Castro Miranda B., Macedo T.R., Cogliati B., Matera J.M. Immunohistochemical Expression of Vascular Endothelial Growth Factor as a Prognostic Marker for Canine Mast Cell Tumor. Med. Top. Comp. Anim. 2021;43:100506. doi: 10.1016/j.tcam.2020.100506. PubMed DOI
Freytag J.O., Queiroz M.R., Govoni V.M., Pereira I.V.A., Pulz L.H., Strefezzi R.D.F., Queiroga F.L., Cogliati B. Prognostic value of immunohistochemical markers in canine cutaneous mast cell tumours: A systematic review and meta-analysis. Vet. Comp. Oncol. 2021;19:529–540. doi: 10.1111/vco.12692. PubMed DOI
Da Silva L., Fonseca-Alves C.E., Thompson J.J., Foster R.A., Wood G.A., Amorim R.L., Coomber B.L. Pilot assessment of vascular endothelial growth factor receptors and trafficking pathways in recurrent and metastatic canine subcutaneous mast cell tumours. Vet. Med. Sci. 2017;3:146–155. doi: 10.1002/vms3.66. PubMed DOI PMC
Kiupel M., Camus M. Diagnosis and Prognosis of Canine Cutaneous Mast Cell Tumors. Vet. Clin. North. Am. Small Anim. Pr. 2019;49:819–836. doi: 10.1016/j.cvsm.2019.04.002. PubMed DOI
Oliveira M.T., Campos M., Lamego L., Magalhães D., Menezes R., Oliveira R., Patanita F., Ferreira D.A. Canine and feline cutaneous mast cell tumour: A comprehensive review of treatments and outcomes. Top. Companion Anim. Med. 2020;41:100472. doi: 10.1016/j.tcam.2020.100472. PubMed DOI
Pratschke K.M., Atherton M.J., Sillito J.A., Lamm C.G. Evaluation of a modified proportional margins approach for surgical resection of mast cell tumors in dogs: 40 cases (2008–2012) J. Am. Vet. Med. Assoc. 2013;243:1436–1441. doi: 10.2460/javma.243.10.1436. PubMed DOI
Chu M.L., Hayes G.M., Henry J.G., Oblak M.L. Comparison of lateral surgical margins of up to two centimeters with margins of three centimeters for achieving tumor-free histologic margins following excision of grade I or II cutaneous mast cell tumors in dogs. J. Am. Vet. Med. Assoc. 2020;256:567–572. doi: 10.2460/javma.256.5.567. PubMed DOI
Saunders H., Thomson M.J., O’Connell K., Bridges J.P., Chau L. Evaluation of a modified proportional margin approach for complete surgical excision of canine cutaneous mast cell tumours and its association with clinical outcome. Vet. Comp. Oncol. 2020;19:604–615. doi: 10.1111/vco.12630. PubMed DOI
Selmic L.E., Ruple A. A systematic review of surgical margins utilized for removal of cutaneous mast cell tumors in dogs. BMC Vet. Res. 2020;16:1–6. doi: 10.1186/s12917-019-2227-8. PubMed DOI PMC
Itoh T., Kojimoto A., Uchida K., Chambers J., Shii H. Long-term postsurgical outcomes of mast cell tumors resected with a margin proportional to the tumor diameter in 23 dogs. J. Vet. Med. Sci. 2021;83:230–233. doi: 10.1292/jvms.20-0281. PubMed DOI PMC
Simpson A.M., Ludwig L.L., Newman S.J., Bergman P.J., Hottinger H.A., Patnaik A.K. Evaluation of surgical margins required for complete excision of cutaneous mast cell tumors in dogs. J. Am. Vet. Med. Assoc. 2004;224:236–240. doi: 10.2460/javma.2004.224.236. PubMed DOI
Donnelly L., Mullin C., Balko J., Goldschmidt M., Krick E., Hume C., Brown D.C., Sorenmo K. Evaluation of histological grade and histologically tumour-free margins as predictors of local recurrence in completely excised canine mast cell tumours. Vet. Comp. Oncol. 2013;13:70–76. doi: 10.1111/vco.12021. PubMed DOI
Ferrari R., Chiti L.E., Manfredi M., Ravasio G., De Zani D., Zani D.D., Giudice C., Gambini M., Dvm D.S. Biopsy of sentinel lymph nodes after injection of methylene blue and lymphoscintigraphic guidance in 30 dogs with mast cell tumors. Vet. Surg. 2020;49:1099–1108. doi: 10.1111/vsu.13483. DOI
Marconato L., Polton G., Stefanello D., Morello E., Ferrari R., Henriques J., Tortorella G., Benali S.L., Bergottini R., Vasconi M.E., et al. Therapeutic impact of regional lymphadenectomy in canine stage II cutaneous mast cell tumours. Vet. Comp. Oncol. 2018;16:580–589. doi: 10.1111/vco.12425. PubMed DOI
Fossum T.W. Cirurgia de pequenos animais. Elsevier; Centro Rio de Janeiro, Brazil: 2021. pp. 546–596.
Milovancev M., Townsend K.L., Tuohy J.L., Gorman E., Bracha S., Curran K.M., Russell D.S. Long-term outcomes of dogs undergoing surgical resection of mast cell tumors and soft tissue sarcomas: A prospective 2-year-long study. Vet. Surg. 2019;49:96–105. doi: 10.1111/vsu.13225. PubMed DOI
Karbe G.T., Davis E., Runge J.J., Brown D.C., Holt D.E. Evaluation of scar revision after inadequate primary excision of cutaneous mast cell tumors in 85 dogs (2000–2013) Vet. Surg. 2021;50:807–815. doi: 10.1111/vsu.13619. PubMed DOI
Mir L.M., Orlowski S., Belehradek J., Paoletti C. Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur. J. Cancer Clin. Oncol. 1991;27:68–72. doi: 10.1016/0277-5379(91)90064-K. PubMed DOI
Mir L., Glass L., Serša G., Teissié J., Domenge C., Miklavčič D., Jaroszeski M., Orlowski S., Reintgen D., Rudolf Z., et al. Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br. J. Cancer. 1998;77:2336–2342. doi: 10.1038/bjc.1998.388. PubMed DOI PMC
Tozon N., Tratar U.L., Znidar K., Sersa G., Teissie J., Cemazar M. Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats. J. Vis. Exp. 2016:e54760. doi: 10.3791/54760. PubMed DOI PMC
Mir L.M., Gehl J., Sersa G., Collins C.G., Garbay J.-R., Billard V., Geertsen P.F., Rudolf Z., O’Sullivan G.C., Marty M. Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes. Eur. J. Cancer Suppl. 2006;4:14–25. doi: 10.1016/j.ejcsup.2006.08.003. DOI
Suzuki D.O., Anselmo J., de Oliveira K.D., Freytag J.O., Rangel M.M., Marques J.L., Ramos A. Numerical Model of Dog Mast Cell Tumor Treated by Electrochemotherapy. Artif. Organs. 2014;39:192–197. doi: 10.1111/aor.12333. PubMed DOI
Pintarelli G., Berkenbrock J., Rassele A., Rangel M., Suzuki D. Computer simulation of commercial conductive gels and their application to increase the safety of electrochemotherapy treatment. Med. Eng. Phys. 2019;74:99–105. doi: 10.1016/j.medengphy.2019.09.016. PubMed DOI
Gerlini G., Di Gennaro P., Borgognoni L. Enhancing anti-melanoma immunity by electrochemotherapy and in vivo dendritic-cell activation. OncoImmunology. 2012;1:1655–1657. doi: 10.4161/onci.21991. PubMed DOI PMC
Calvet C.Y., Famin D., André F.M., Mir L.M. Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells. OncoImmunology. 2014;3:e28131. doi: 10.4161/onci.28131. PubMed DOI PMC
Spugnini E.P., Baldi A. Electrochemotherapy in Veterinary Oncology. Vet. Clin. North. Am. Small Anim. Pr. 2019;49:967–979. doi: 10.1016/j.cvsm.2019.04.006. PubMed DOI
Spugnini E.P., Vincenzi B., Baldi F., Citro G., Baldi A. Adjuvant electrochemotherapy for the treatment of incompletely resected canine mast cell tumors. Anticancer Res. 2007;26:4585–4589. PubMed
Kodre V., Cemazar M., Pecar J., Sersa G., Cor A., Tozon N. Electrochemotherapy Compared to Surgery for Treatment of Canine Mast Cell Tumours. Vivo. 2009;23:55–62. PubMed
Spugnini E., Vincenzi B., Citro G., Dotsinsky I., Mudrov T., Baldi A. Evaluation of Cisplatin as an Electrochemotherapy Agent for the Treatment of Incompletely Excised Mast Cell Tumors in Dogs. J. Vet. Intern. Med. 2011;25:407–411. doi: 10.1111/j.1939-1676.2011.0678.x. PubMed DOI
Lowe R., Gavazza A., Impellizeri J.A., Soden D.M., Lubas G. The treatment of canine mast cell tumours with electrochemotherapy with or without surgical excision. Vet. Comp. Oncol. 2016;15:775–784. doi: 10.1111/vco.12217. PubMed DOI
Cemazar M., Avgustin J.A., Pavlin D., Sersa G., Poli A., Levacic A.K., Tesic N., Tratar U.L., Rak M., Tozon N. Efficacy and safety of electrochemotherapy combined with peritumoral IL-12 gene electrotransfer of canine mast cell tumours. Vet. Comp. Oncol. 2016;15:641–654. doi: 10.1111/vco.12208. PubMed DOI
Salvadori C., Svara T., Rocchigiani G., Millanta F., Pavlin D., Cemazar M., Tratar U.L., Sersa G., Tozon N., Poli A. Effects of electrochemotherapy with cisplatin and peritumoral IL-12 gene electrotransfer on canine mast cell tumors: A histopathologic and immunohistochemical study. Radiol. Oncol. 2017;51:286–294. doi: 10.1515/raon-2017-0035. PubMed DOI PMC
Dobson J.M., Scase T.J. Advances in the diagnosis and management of cutaneous mast cell tumours in dogs. J. Small Anim. Pr. 2007;48:424–431. doi: 10.1111/j.1748-5827.2007.00366.x. PubMed DOI
Dobson J., Cohen S., Gould S. Treatment of canine mast cell tumours with prednisolone and radiotherapy. Vet. Comp. Oncol. 2004;2:132–141. doi: 10.1111/j.1476-5810.2004.00048.x. PubMed DOI
Al-Sarraf R., Mauldin G.N., Patnaik A.K., Meleo K.A. A Prospective Study of Radiation Therapy for the Treatment of Grade 2 Mast Cell Tumors in 32 Dogs. J. Vet. Intern. Med. 1996;10:376–378. doi: 10.1111/j.1939-1676.1996.tb02084.x. PubMed DOI
Frimberger A., Moore A.S., LaRue S.M., Gliatto J.M., Bengtson A.E. Radiotherapy of incompletely resected, moderately differentiated mast cell tumors in the dog: 37 cases (1989-1993) J. Am. Anim. Hosp. Assoc. 1997;33:320–324. doi: 10.5326/15473317-33-4-320. PubMed DOI
LaDue T., Price G.S., Dodge R., Page R.L., Thrall D.E. Radiation therapy for incompletely resected canine mast cell tumors. Vet. Radiol. Ultrasound. 1998;39:57–62. doi: 10.1111/j.1740-8261.1998.tb00326.x. PubMed DOI
Poirier V.J., Adams W.M., Forrest L.J., Green E.M., Dubielzig R.R., Vail D.M. Radiation Therapy for Incompletely Excised Grade II Canine Mast Cell Tumors. J. Am. Anim. Hosp. Assoc. 2006;42:430–434. doi: 10.5326/0420430. PubMed DOI
Kry K.L., Boston S.E. Additional Local Therapy With Primary Re-Excision or Radiation Therapy Improves Survival and Local Control After Incomplete or Close Surgical Excision of Mast Cell Tumors in Dogs. Vet. Surg. 2014;43:182–189. doi: 10.1111/j.1532-950X.2014.12099.x. PubMed DOI
Chaffin K., Thrall D.E. Results of radiation therapy in 19 dogs with cutaneous mast cell tumor and regional lymph node metastasis. Vet. Radiol. Ultrasound. 2002;43:392–395. doi: 10.1111/j.1740-8261.2002.tb01023.x. PubMed DOI
Lejeune A., Skorupski K., Frazier S., Vanhaezebrouck I., Rebhun R.B., Reilly C.M., Rodriguez C.O., Jr. Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999–2012) Vet. Comp. Oncol. 2013;13:267–280. doi: 10.1111/vco.12042. PubMed DOI PMC
Mendez S.E., Drobatz K.J., Duda L.E., White P., Kubicek L., Sorenmo K.U. Treating the locoregional lymph nodes with radiation and/or surgery significantly improves outcome in dogs with high-grade mast cell tumours. Vet. Comp. Oncol. 2019;18:239–246. doi: 10.1111/vco.12541. PubMed DOI
Carlsten K., London C.A., Haney S., Burnett R.C., Avery A.C., Thamm D. Multicenter Prospective Trial of Hypofractionated Radiation Treatment, Toceranib, and Prednisone for Measurable Canine Mast Cell Tumors. J. Vet. Intern. Med. 2011;26:135–141. doi: 10.1111/j.1939-1676.2011.00851.x. PubMed DOI PMC
Stiborova K., Treggiari E., Amores-Fuster I., Del Busto I., Killick D., Maddox T., Marrington M., Mason S.L., Blackwood L. Haematologic toxicity in dogs with mast cell tumours treated with vinblastine/prednisolone chemotherapy with/without radiotherapy. J. Small Anim. Pr. 2019;60:534–542. doi: 10.1111/jsap.13047. PubMed DOI
Boyle G.M., D’Souza M.M.A., Pierce C.J., Adams R.A., Cantor A.S., Johns J.P., Maslovskaya L., Gordon V.A., Reddell P., Parsons P. Intra-Lesional Injection of the Novel PKC Activator EBC-46 Rapidly Ablates Tumors in Mouse Models. PLoS ONE. 2014;9:e108887. doi: 10.1371/journal.pone.0108887. PubMed DOI PMC
Miller J., Campbell J., Blum A., Reddell P., Gordon V., Schmidt P., Lowden S. Dose Characterization of the Investigational Anticancer Drug Tigilanol Tiglate (EBC-46) in the Local Treatment of Canine Mast Cell Tumors. Front. Vet. Sci. 2019;6:106. doi: 10.3389/fvets.2019.00106. PubMed DOI PMC
Jones P.D., Campbell J.E., Brown G., Johannes C.M., Reddell P. Recurrence-free interval 12 months after local treatment of mast cell tumors in dogs using intratumoral injection of tigilanol tiglate. J. Vet. Intern. Med. 2020;35:451–455. doi: 10.1111/jvim.16018. PubMed DOI PMC
Reddell P., De Ridder T.R., Morton J.M., Jones P.D., Campbell J.E., Brown G., Johannes C.M., Schmidt P.F., Gordon V. Wound formation, wound size, and progression of wound healing after intratumoral treatment of mast cell tumors in dogs with tigilanol tiglate. J. Vet. Intern. Med. 2021;35:430–441. doi: 10.1111/jvim.16009. PubMed DOI PMC
De Ridder T.R., Campbell J.E., Burke-Schwarz C., Clegg D., Elliot E.L., Geller S., Kozak W., Pittenger S.T., Pruitt J.B., Riehl J., et al. Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC -46) J. Vet. Intern. Med. 2020;35:415–429. doi: 10.1111/jvim.15806. PubMed DOI PMC
Brown G.K., Campbell J.E., Jones P.D., De Ridder T.R., Reddell P., Johannes C.M. Intratumoural Treatment of 18 Cytologically Diagnosed Canine High-Grade Mast Cell Tumours With Tigilanol Tiglate. Front. Vet. Sci. 2021;8 doi: 10.3389/fvets.2021.675804. PubMed DOI PMC
Burton J., Venable R., Vail D., Williams L., Clifford C., Axiak-Bechtel S., Avery A., Thamm D. Pulse-Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs. J. Vet. Intern. Med. 2015;29:1098–1104. doi: 10.1111/jvim.13573. PubMed DOI PMC
Stanclift R.M., Gilson S.D. Evaluation of neoadjuvant prednisone administration and surgical excision in treatment of cutaneous mast cell tumors in dogs. J. Am. Vet. Med. Assoc. 2008;232:53–62. doi: 10.2460/javma.232.1.53. PubMed DOI
Taylor F., Gear R., Hoather T., Dobson J. Chlorambucil and prednisolone chemotherapy for dogs with inoperable mast cell tumours: 21 cases. J. Small Anim. Pr. 2009;50:284–289. doi: 10.1111/j.1748-5827.2009.00732.x. PubMed DOI
Rassnick K.M., Bailey D.B., Russell D.S., Flory A.B., Kiselow M.A., Intile J., Malone E.K., Balkman C.E., Barnard S.M. A phase II study to evaluate the toxicity and efficacy of alternating CCNU and high-dose vinblastine and prednisone (CVP) for treatment of dogs with high-grade, metastatic or nonresectable mast cell tumours. Vet. Comp. Oncol. 2010;8:138–152. doi: 10.1111/j.1476-5829.2010.00217.x. PubMed DOI
Govier S.M. Principles of treatment for mast cell tumors. Clin. Tech. Small Anim. Pr. 2003;18:103–106. doi: 10.1053/svms.2003.36624. PubMed DOI
Horta R., LaValle G., Costa M., Moura L., Marcinowska A., Araújo R. Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk. Arq. Bras. Med. Vet. Zootec. 2017;69:1426–1436. doi: 10.1590/1678-4162-9172. DOI
Davies D.R., Wyatt K.M., Jardine J.E., Robertson I.D., Irwin P. Vinblastine and Prednisolone as Adjunctive Therapy for Canine Cutaneous Mast Cell Tumors. J. Am. Anim. Hosp. Assoc. 2004;40:124–130. doi: 10.5326/0400124. PubMed DOI
Trumel C., Bourgès-Abella N., Touron C., Lanore D., Geffré A., Diquelou A., Guelfi J.F., Braun J.P. Adverse Haematological Effects of Vinblastine, Prednisolone and Cimetidine Treatment: A Retrospective Study in Fourteen Dogs with Mast Cell Tumours. J. Vet. Med. Ser. A. 2005;52:275–279. doi: 10.1111/j.1439-0442.2005.00725.x. PubMed DOI
Thamm D., Turek M., Vail D. Outcome and Prognostic Factors Following Adjuvant Prednisone/Vinblastine Chemotherapy for High-Risk Canine Mast Cell Tumour: 61 Cases. J. Vet. Med. Sci. 2006;68:581–587. doi: 10.1292/jvms.68.581. PubMed DOI
Rosenthal R.C. Clinical applications of Vinca alkaloids. J. Am. Vet. Med. Assoc. 1981;179 PubMed
Golden D.L., Langston V. Uses of vincristine and vinblastine in dogs and cats. J. Am. Vet. Med. Assoc. 1988;193 PubMed
Rungsipipat A., Srichat W., Manachai N., Jearanai W., Wangnaitham S., Tangkawattana P., Tangkawattana S. Clinical evaluation of canine mast cell tumor treatment between combined vinblastine and prednisolone and single prednisolone. Comp. Clin. Path. 2009;18:77–84. doi: 10.1007/s00580-008-0758-7. DOI
Vickery K.R., Wilson H., Vail D.M., Thamm D.H. Dose-escalating vinblastine for the treatment of canine mast cell tumour. Vet. Comp. Oncol. 2008;6:111–119. doi: 10.1111/j.1476-5829.2007.00147.x. PubMed DOI
Rassnick K., Bailey D., Flory A., Balkman C., Kiselow M., Intile J., Autio K. Efficacy of Vinblastine for Treatment of Canine Mast Cell Tumors. J. Vet. Intern. Med. 2008;22:1390–1396. doi: 10.1111/j.1939-1676.2008.0195.x. PubMed DOI
Varela J.C.S., Pecceu E., Handel I., Lawrence J. Tolerability of a rapid-escalation vinblastine-prednisolone protocol in dogs with mast cell tumours. Vet. Med. Sci. 2016;2:266–280. doi: 10.1002/vms3.42. PubMed DOI PMC
Bailey D., Rassnick K., Kristal O., Chretin J., Balkman C. Phase I Dose Escalation of Single-Agent Vinblastine in Dogs. J. Vet. Intern. Med. 2008;22:1397–1402. doi: 10.1111/j.1939-1676.2008.0196.x. PubMed DOI
Kluthcovsky L.C., Firmo B.F., Cassino P.C., De Nardi A.B., Castro J.L.C., Halila R.L., Filho J.R.E. Comparison of Two Different Vinblastine Dosages for Treatment of Cutaneous Mast Cell Tumor in Dogs. Acta Sci. Vet. 2020;48 doi: 10.22456/1679-9216.101997. DOI
Hosoya K., Kisseberth W.C., Alvarez F.J., Lara-Garcia A., Beamer G.L., Stromberg P.C., Couto C.G. Adjuvant CCNU (Lomustine) and Prednisone Chemotherapy for Dogs With Incompletely Excised Grade 2 Mast Cell Tumors. J. Am. Anim. Hosp. Assoc. 2009;45:14–18. doi: 10.5326/0450014. PubMed DOI
Hay J.K., Larson V.S. Lomustine (CCNU) and prednisone chemotherapy for high-grade completely excised canine mast cell tumors. Can. Vet. J. = La Rev. Vet. Can. 2019;60:1326–1330. PubMed PMC
Cooper M., Tsai X., Bennett P. Combination CCNU and vinblastine chemotherapy for canine mast cell tumours: 57 cases. Vet. Comp. Oncol. 2009;7:196–206. doi: 10.1111/j.1476-5829.2009.00190.x. PubMed DOI
Teng S.-P., Hsu W.-L., Chiu C.-Y., Wong M.-L., Chang S.-C. Overexpression of P-glycoprotein, STAT3, phospho-STAT3 and KIT in spontaneous canine cutaneous mast cell tumours before and after prednisolone treatment. Vet. J. 2012;193:551–556. doi: 10.1016/j.tvjl.2012.01.033. PubMed DOI
Linde K.J., Stockdale S.L., Mison M.B., Perry J.A. The effect of prednisone on histologic and gross characteristics in canine mast cell tumors. Can. Vet. J. = La Rev. Vet. Can. 2021;62:45–50. PubMed PMC
Horta R.D.S., Lavalle G.E., Monteiro L.N., dos Reis F.A., Costa M.D.P., Giuliano A., Cassali G.D., Dobson J. Evaluation of Histological, Immunohistochemical, Clinical and Genetic Prognostic Factors Associated with the Response of Canine Mast Cell Tumours to Glucocorticotherapy. J. Comp. Pathol. 2018;165:72–81. doi: 10.1016/j.jcpa.2018.10.001. PubMed DOI
Ginn P.E., Fox L.E., Brower J.C., Gaskin A., Kurzman I.D., Kubilis P.S. Immunohistochemical Detection of p53 Tumor-Suppressor Protein is a Poor Indicator of Prognosis for Canine Cutaneous Mast Cell Tumors. Vet. Pathol. 2000;37:33–39. doi: 10.1354/vp.37-1-33. PubMed DOI
Miyoshi N., Tojo E., Oishi A., Fujiki M., Misumi K., Sakamoto H., Kameyama K., Shimizu T., Yasuda N. Immunohistochemical detection of P-glycoprotein (PGP) and multidrug resistance-associated protein (MRP) in canine cutaneous mast cell tumors. J. Vet. Med. Sci. 2002;64:531–533. doi: 10.1292/jvms.64.531. PubMed DOI
Nakaichi M., Takeshita Y., Okuda M., Nakamoto Y., Itamoto K., Une S., Sasaki N., Kadosawa T., Takahashi T., Taura Y. Expression of the MDR1 Gene and P-Glycoprotein in Canine Mast Cell Tumor Cell Lines. J. Vet. Med. Sci. 2007;69:111–115. doi: 10.1292/jvms.69.111. PubMed DOI
Colleoni M., Rocca A., Sandri M.T., Zorzino L., Masci G., Nolè F., Peruzzotti G., Robertson C., Orlando L., Cinieri S., et al. Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: Antitumor activity and correlation with vascular endothelial growth factor levels. Ann. Oncol. 2002;13:73–80. doi: 10.1093/annonc/mdf013. PubMed DOI
Pasquier E., Kavallaris M., André N. Metronomic chemotherapy: New rationale for new directions. Nat. Rev. Clin. Oncol. 2010;7:455–465. doi: 10.1038/nrclinonc.2010.82. PubMed DOI
Tripp C., Fidel J., Anderson C., Patrick M., Pratt C., Sellon R., Bryan J. Tolerability of Metronomic Administration of Lomustine in Dogs with Cancer. J. Vet. Intern. Med. 2011;25:278–284. doi: 10.1111/j.1939-1676.2011.0684.x. PubMed DOI
Leach T.N., Childress M.O., Greene S.N., Mohamed A.S., Moore G.E., Schrempp D.R., Lahrman S.R., Knapp D.W. Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer. Vet. Comp. Oncol. 2011;10:102–112. doi: 10.1111/j.1476-5829.2011.00280.x. PubMed DOI
Gaspar T.B., Henriques J., Marconato L., Queiroga F.L. The use of low-dose metronomic chemotherapy in dogs-insight into a modern cancer field. Vet. Comp. Oncol. 2017;16:2–11. doi: 10.1111/vco.12309. PubMed DOI
Thamm D.H., Mauldin E.A., Vail D.M. Prednisone and vinblastine chemotherapy for canine mast cell tumor—41 cases (1992–1997) J. Vet. Intern. Med. 1999;13:491–497. PubMed
Camps-Palau M.A., Leibman N.F., Elmslie R., Lana S.E., Plaza S., McKnight J.A., Risbon R., Bergman P.J. Treatment of canine mast cell tumours with vinblastine, cyclophosphamide and prednisone: 35 cases (1997?2004) Vet. Comp. Oncol. 2007;5:156–167. doi: 10.1111/j.1476-5829.2006.00125.x. PubMed DOI
Rassnick K.M., Moore A.S., Williams L.E., London C.A., Kintzer P.P., Engler S.J., Cotter S.M. Treatment of Canine Mast Cell Tumors with CCNU (Lomustine) J. Vet. Intern. Med. 1999;13:601–605. doi: 10.1111/j.1939-1676.1999.tb02217.x. PubMed DOI
Olsen J.A., Thomson M., O’Connell K., Wyatt K. Combination vinblastine, prednisolone and toceranib phosphate for treatment of grade II and III mast cell tumours in dogs. Vet. Med. Sci. 2018;4:237–251. doi: 10.1002/vms3.106. PubMed DOI PMC
London C.A. Tyrosine Kinase Inhibitors in Veterinary Medicine. Top. Companion Anim. Med. 2009;24:106–112. doi: 10.1053/j.tcam.2009.02.002. PubMed DOI
Soria J., Massard C., Magné N., Bader T., Mansfield C., Blay J., Bui B., Moussy A., Hermine O., Armand J. Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers. Eur. J. Cancer. 2009;45:2333–2341. doi: 10.1016/j.ejca.2009.05.010. PubMed DOI
Ogilvie G., Ahn A. Masitinib–the efficacy of targeted therapy in veterinary medicine. Vet. Cancer Soc. Newsl. Summer. 2010;34:6–11.
Hahn K.A., Legendre A.M., Shaw N.G., Phillips B., Ogilvie G.K., Prescott D.M., Atwater S.W., Carreras J.K., Lana S.E., LaDue T., et al. Evaluation of 12- and 24-month survival rates after treatment with masitinib in dogs with nonresectable mast cell tumors. Am. J. Vet. Res. 2010;71:1354–1361. doi: 10.2460/ajvr.71.11.1354. PubMed DOI
London C.A., Hannah A.L., Zadovoskaya R., Chien M.B., Kollias-Baker C., Rosenberg M., Downing S., Post G., Boucher J., Shenoy N., et al. Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies. Clin. Cancer Res. 2003;9:2755–2768. PubMed
Weishaar K., Ehrhart E., Avery A., Charles J., Elmslie R., Vail D., London C., Clifford C., Eickhoff J., Thamm D. c-Kit Mutation and Localization Status as Response Predictors in Mast Cell Tumors in Dogs Treated with Prednisone and Toceranib or Vinblastine. J. Vet. Intern. Med. 2017;32:394–405. doi: 10.1111/jvim.14889. PubMed DOI PMC
Mitchell L., Thamm D., Biller B. Clinical and Immunomodulatory Effects of Toceranib Combined with Low-Dose Cyclophosphamide in Dogs with Cancer. J. Vet. Intern. Med. 2012;26:355–362. doi: 10.1111/j.1939-1676.2011.00883.x. PubMed DOI
Amagai Y., Tanaka A., Jung K., Matsuda A., Oida K., Nishikawa S., Jang H., Ishizaka S., Matsuda H. Production of stem cell factor in canine mast cell tumors. Res. Vet. Sci. 2013;96:124–126. doi: 10.1016/j.rvsc.2013.10.014. PubMed DOI
Horta R.D.S., Giuliano A., LaValle G.E., Costa M.D.P., De Ara�Jo R., Constantino-Casas F., Dobson J.M. Clinical, histological, immunohistochemical and genetic factors associated with measurable response of high-risk canine mast cell tumours to tyrosine kinase inhibitors. Oncol. Lett. 2017;15:129–136. doi: 10.3892/ol.2017.7323. PubMed DOI PMC
Smrkovski O.A., Essick L., Rohrbach B.W., Legendre A.M. Masitinib mesylate for metastatic and non-resectable canine cutaneous mast cell tumours. Vet. Comp. Oncol. 2013;13:314–321. doi: 10.1111/vco.12053. PubMed DOI
London C., Mathie T., Stingle N., Clifford C., Haney S., Klein M.K., Beaver L., Vickery K., Vail D.M., Hershey B., et al. Preliminary evidence for biologic activity of toceranib phosphate (Palladia®) in solid tumours. Vet. Comp. Oncol. 2012;10:194–205. doi: 10.1111/j.1476-5829.2011.00275.x. PubMed DOI PMC
Grant J., North S., Lanore D. Clinical response of masitinib mesylate in the treatment of canine macroscopic mast cell tumours. J. Small Anim. Pr. 2016;57:283–290. doi: 10.1111/jsap.12480. PubMed DOI
Robat C., London C., Bunting L., McCartan L., Stingle N., Selting K., Kurzman I., Vail D.M. Safety evaluation of combination vinblastine and toceranib phosphate (Palladia®) in dogs: A phase I dose-finding study. Vet. Comp. Oncol. 2011;10:174–183. doi: 10.1111/j.1476-5829.2011.00261.x. PubMed DOI PMC
Pan X., Tsimbas K., Kurzman I.D., Vail D.M. Safety evaluation of combination CCNU and continuous toceranib phosphate (Palladia®) in tumour-bearing dogs: A phase I dose-finding study. Vet. Comp. Oncol. 2014;14:202–209. doi: 10.1111/vco.12091. PubMed DOI
Bavcar S., de Vos J., Kessler M., de Fornel P., Buracco P., Murphy S., Hirschberger J., Argyle D. Combination toceranib and lomustine shows frequent high grade toxicities when used for treatment of non-resectable or recurrent mast cell tumours in dogs: A European multicentre study. Vet. J. 2017;224:1–6. doi: 10.1016/j.tvjl.2017.04.010. PubMed DOI
Gieger T., Northrup N., Wall M. Clinical management of mast cell tumors in dogs. Compend. Contin. Educ. Pract. Vet. 2005;27:56–68.
Peters L.J., Kovacic J.P. Histamine: Metabolism, physiology, and pathophysiology with applications in veterinary medicine. J. Vet. Emerg. Crit. Care. 2009;19:311–328. doi: 10.1111/j.1476-4431.2009.00434.x. PubMed DOI
Guedes A.G., Rudé E.P., Rider M.A. Evaluation of histamine release during constant rate infusion of morphine in dogs. Vet. Anaesth. Analg. 2006;33:28–35. doi: 10.1111/j.1467-2995.2005.00218.x. PubMed DOI
O’Keefe D.A. Canine Mast Cell Tumors. Vet. Clin. North. Am. Small Anim. Pr. 1990;20:1105–1115. doi: 10.1016/S0195-5616(90)50087-X. PubMed DOI
Pavlin D., Cemazar M., Cör A., Sersa G., Pogacnik A., Tozon N. Electrogene therapy with interleukin-12 in canine mast cell tumors. Radiol. Oncol. 2011;45:31–39. doi: 10.2478/v10019-010-0041-9. PubMed DOI PMC
Lin T.-Y., Fenger J., Murahari S., Bear M.D., Kulp S.K., Wang D., Chen C.-S., Kisseberth W.C., London C.A. AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Blood. 2010;115:4217–4225. doi: 10.1182/blood-2009-07-231985. PubMed DOI PMC
Nagamine M.K., Sanches D.S., Pinello K.C., Torres L.N., Mennecier G., Latorre A.O., Fukumasu H., Dagli M.L.Z. In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor. Vet. Res. Commun. 2011;35:391–399. doi: 10.1007/s11259-011-9474-x. PubMed DOI
Keller A., Wingelhofer B., Peter B., Bauer K., Berger D., Gamperl S., Reifinger M., Cerny-Reiterer S., Moriggl R., Willmann M., et al. The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. Vet. Comp. Oncol. 2017;16:55–68. doi: 10.1111/vco.12311. PubMed DOI PMC
Cletzer E., Klahn S., Dervisis N., LeRoith T. Identification of the JAK-STAT pathway in canine splenic hemangiosarcoma, thyroid carcinoma, mast cell tumor, and anal sac adenocarcinoma. Vet. Immunol. Immunopathol. 2019;220:109996. doi: 10.1016/j.vetimm.2019.109996. PubMed DOI