Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
16-13399S
Grantová Agentura České Republiky - International
17-04047S
Grantová Agentura České Republiky - International
17-30833A
Agentura zdravotnického výzkumu (AZV) - International
1792218
Grantová Agentura, Univerzita Karlova - International
17-04047S
Czech Science Foundation - International
17-30833A
Czech Science Foundation - International
16-13399S
Charles University - International
67985823
Charles University - International
Czech Academy of Sciences - International
LO1611
NIMH NIH HHS - United States
Ministry of Education - International
PubMed
31002202
DOI
10.1111/apha.13282
Knihovny.cz E-resources
- Keywords
- GABA interneurons, fMRI, humans, oscillations, psychosis, rats,
- MeSH
- Humans MeSH
- Brain physiopathology MeSH
- Nerve Net physiopathology MeSH
- Neural Pathways physiopathology MeSH
- Neurons physiology MeSH
- Schizophrenia physiopathology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Despite the substantial knowledge accumulated by past research, the exact mechanisms of the pathogenesis of schizophrenia and causal treatments still remain unclear. Deficits of cognition and information processing in schizophrenia are today often viewed as the primary and core symptoms of this devastating disorder. These deficits likely result from disruptions in the coordination of neuronal and neural activity. The aim of this review is to bring together convergent evidence of discoordinated brain circuits in schizophrenia at multiple levels of resolution, ranging from principal cells and interneurons, neuronal ensembles and local circuits, to large-scale brain networks. We show how these aberrations could underlie deficits in cognitive control and other higher order cognitive-behavioural functions. Converging evidence from both animal models and patients with schizophrenia is presented in an effort to gain insight into common features of deficits in the brain information processing in this disorder, marked by disruption of several neurotransmitter and signalling systems and severe behavioural outcomes.
References provided by Crossref.org
The Role of Zebrafish and Laboratory Rodents in Schizophrenia Research
