The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
FS/18/23/33512
British Heart Foundation - United Kingdom
PubMed
31055022
DOI
10.1016/j.gene.2019.05.002
PII: S0378-1119(19)30457-3
Knihovny.cz E-zdroje
- Klíčová slova
- ADH1B, Alcohol intake, Binge drinking, FTO, Polymorphism, Sex, Smoking,
- MeSH
- alkoholdehydrogenasa genetika MeSH
- alkoholismus genetika MeSH
- běloši genetika MeSH
- gen pro FTO genetika MeSH
- genetické asociační studie MeSH
- genotyp MeSH
- interakce genů a prostředí MeSH
- jednonukleotidový polymorfismus * MeSH
- kouření genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- nárazové pití alkoholu genetika MeSH
- pití alkoholu genetika MeSH
- prospektivní studie MeSH
- senioři MeSH
- sexuální faktory MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- ADH1B protein, human MeSH Prohlížeč
- alkoholdehydrogenasa MeSH
- FTO protein, human MeSH Prohlížeč
- gen pro FTO MeSH
BACKGROUND: Alcohol intake and tobacco smoking have significant negative health consequences and both are influenced by genetic predispositions. Some studies suggest that the FTO gene is associated with alcohol consumption. We investigated whether a tagging variant (rs17817449) within the FTO gene is associated with alcohol intake, problem drinking and smoking behaviour. METHODS: We analysed data from 26,792 Caucasian adults (47.2% of males; mean age 58.9 (±7.3) years), examined through the prospective cohort HAPIEE study. The primary outcomes were daily alcohol consumption, binge drinking, problem drinking (CAGE score 2+) and smoking status in relation to tagging variants within the FTO and ADH1B genes. RESULTS: We found no significant association of the FTO polymorphism with smoking status in either sex. The associations of the FTO polymorphism with drinking pattern were inconsistent and differed by gender. In men, GG homozygote carriers had lower odds of problem drinking (OR 0.85, 95% CI 0.75-0.96, p = 0.03). In women, the combination of the FTO/ADH1B GG/+A genotypes doubled the risk of binge drinking (OR 2.10, 95% CI 1.19-3.71, p < 0.05), and the risk was further increased among smoking women (OR 4.10, 95% CI 1.64-10.24, p = 0.008). CONCLUSIONS: In this large population study, the FTO gene appeared associated with binge and problem drinking, and the associations were modified by sex, smoking status and the ADH1B polymorphism.
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