PARTICLE - The RNA podium for genomic silencers
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31058319
DOI
10.1002/jcp.28739
Knihovny.cz E-resources
- Keywords
- epigenetics, histone, long non-coding RNA, methyltransferase, radiation, triplex,
- MeSH
- Radiation Dosage MeSH
- DNA (Cytosine-5-)-Methyltransferase 1 genetics MeSH
- Genome, Human radiation effects MeSH
- Genomics MeSH
- Histone Methyltransferases genetics MeSH
- Humans MeSH
- Methionine Adenosyltransferase genetics MeSH
- Tumor Suppressor Proteins genetics MeSH
- Neoplasms genetics radiotherapy MeSH
- WW Domain-Containing Oxidoreductase genetics MeSH
- Promoter Regions, Genetic genetics MeSH
- Radiation Exposure adverse effects MeSH
- Gene Expression Regulation, Neoplastic radiation effects MeSH
- RNA, Long Noncoding genetics MeSH
- RNA Interference radiation effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- DNA (Cytosine-5-)-Methyltransferase 1 MeSH
- DNMT1 protein, human MeSH Browser
- Histone Methyltransferases MeSH
- MAT2A protein, human MeSH Browser
- Methionine Adenosyltransferase MeSH
- Tumor Suppressor Proteins MeSH
- WW Domain-Containing Oxidoreductase MeSH
- RNA, Long Noncoding MeSH
- WWOX protein, human MeSH Browser
Radiation exposure can evoke cellular stress responses. Emerging recognition that long non-coding RNAs (lncRNAs) act as regulators of gene expression has broadened the spectra of molecules controlling the genomic landscape upon alterations in environmental conditions. Knowledge of the mechanisms responding to low dose irradiation (LDR) exposure is very limited yet most likely involve subtle ancillary molecular pathways other than those protecting the cell from direct cellular damage. The discovery that transcription of the lncRNA PARTICLE (promoter of MAT2A- antisense radiation-induced circulating lncRNA; PARTICL) becomes dramatically instigated within a day after LDR exposure introduced a new gene regulator onto the biological landscape. PARTICLE affords an RNA binding platform for genomic silencers such as DNA methyltransferase 1 and histone tri-methyltransferases to reign in the expression of tumor suppressors such as its neighboring MAT2A in cis as well as WWOX in trans. In silico evidence offers scope to speculate that PARTICLE exploits the abundance of Hoogsten bonds that exist throughout mammalian genomes for triplex formation, presumably a vital feature within this RNA silencer. PARTICLE may provide a buffering riboswitch platform for S-adenosylmethionine. The correlation of PARTICLE triplex formation sites within tumor suppressor genes and their abundance throughout the genome at cancer-related hotspots offers an insight into potential avenues worth exploring in future therapeutic endeavors.
Chair of Radiation Biology Technical University Munich Munich Germany
RP1 Experimental Neurobiology National Institute of Mental Health Klecany Czech Republic
References provided by Crossref.org
