Oncological outcome of surgical management in patients with recurrent uterine cancer-a multicenter retrospective cohort study-CEEGOG EX01 Trial
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, multicentrická studie
PubMed
31064862
DOI
10.1136/ijgc-2019-000292
PII: ijgc-2019-000292
Knihovny.cz E-zdroje
- Klíčová slova
- secondary cytoreductive surgery, uterine cancer,
- MeSH
- cytoredukční chirurgie metody MeSH
- doba přežití bez progrese choroby MeSH
- dospělí MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokální recidiva nádoru mortalita patologie chirurgie MeSH
- míra přežití MeSH
- nádory dělohy mortalita patologie chirurgie MeSH
- nádory děložního čípku mortalita patologie chirurgie MeSH
- přežívající onkologičtí pacienti MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- senioři MeSH
- staging nádorů MeSH
- výsledek terapie MeSH
- záchranná terapie metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
OBJECTIVES: To assess the survival of patients who have received an operation for recurrent cervical and endometrial cancer and to determine prognostic variables for improved oncologic outcome. METHODS: A retrospective multicenter analysis of the medical records of 518 patients with cervical (N = 288) or endometrial cancer (N = 230) who underwent surgery for disease recurrence and who had completed at least 1 year of follow-up. RESULTS: The median survival reached 57 months for patients with cervical cancer and 113 months for patients with endometrial cancer after surgical treatment of recurrence (p = 0.036). Histological sub-type had a significant impact on overall survival, with the best outcome in endometrial endometrioid cancer (121 months), followed by cervical squamous cell carcinoma, cervical adenocarcinoma, or other types of endometrial cancer (81 vs 35 vs 35 months; p <0.001). The site of recurrence did not significantly influence survival in cervical or in endometrial cancer. Cancer stage at first diagnosis, tumor grade, lymph node status at recurrence, progression-free interval after first diagnosis, and free resection margins were associated with improved overall survival on univariate analysis. On multivariate analysis, the stage at first diagnosis and resection margins were significant independent predictive parameters of an improved oncologic outcome. CONCLUSION: Long-term survival can be achieved via secondary cytoreductive surgery in selected patients with recurrent cervical and endometrial cancer. An excellent outcome is possible even if the recurrence site is located in the lymph nodes. The possibility of achieving complete resection should be the main criterion for patient selection.
Département de Cancérologie Gynécologique Oscar Lambret Center Lille France
Department of Gynecologic Oncology MD Anderson Cancer Center Madrid Spain
Department of Gynecologic Oncology National Cancer Institute Bratislava Slovakia
Department of Gynecological Oncology University Medical Center Utrecht Utrecht Netherlands
Department of Gynecology and Obstetrics Jagiellonian University Medical College Krakow Poland
Department of Gynecology Obstetrics and Urology Sapienza University of Rome Rome Italy
Department of Obstetrics and Gynecology Clínica Universidad de Navarra Pamplona Spain
Division of Women's Health Federal University of Minas Gerais Belo Horizonte Brazil
Fondazione IRCCS IstitutoNazionale dei Tumori Milan Italy
Gynecologic Oncology La Paz University Hospital Madrid Spain
Institute for Biostatistics and Analyses Masaryk University Brno Czech Republic
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