Use of Prostate Specific Antigen Density Combined with Multiparametric Magnetic Resonance Imaging Improves Triage for Prostate Biopsy
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
31067560
DOI
10.1159/000500350
PII: 000500350
Knihovny.cz E-zdroje
- Klíčová slova
- Biopsy, Fusion, Magnetic resonance imaging, Prostate cancer, Prostate specific antigen density,
- MeSH
- biopsie * MeSH
- časná detekce nádoru normy MeSH
- lékařská onkologie normy MeSH
- lidé středního věku MeSH
- lidé MeSH
- multiparametrická magnetická rezonance * MeSH
- nádory prostaty diagnostické zobrazování patologie MeSH
- prostata patologie MeSH
- prostatický specifický antigen krev MeSH
- reprodukovatelnost výsledků MeSH
- rozhodování MeSH
- senioři MeSH
- ultrasonografie MeSH
- ultrazvukem navigovaná biopsie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- prostatický specifický antigen MeSH
BACKGROUND: Multi-parametric magnetic resonance imaging (mpMRI)-directed biopsy for prostate cancer (PC) diagnosis improves the detection of clinically significant prostate cancer (CSPC) and decreases the rate of over-diagnosis of insignificant disease. The aim of this study was to investigate the value of mpMRI combined with prostate specific antigen density (PSAD) in the decision making related to the biopsy. METHODS: mpMRI and mpMRI/transrectal ultrasound fusion targeted biopsies with subsequent systematic biopsies were performed in 397 patients (223 biopsy-naïve and 174 with a previous biopsy). Detection rates of (CSPC) and insignificant PC were stratified using the PIRADS score, and the number of avoidable biopsies and missed (CSPC) were plotted against PSAD values of 0.1-0.5 ng/mL2. RESULTS: PIRADS <3 and PSAD <0.2 ng/mL2 were the safest criteria for not performing a biopsy. When applied to the biopsy-naïve group, 21.5% (48/223) of the biopsies could have been avoided and 3.7% (3/82) of CSPC would have been missed. In the repeat biopsy group, 12.6% (22/174) of biopsies could have been avoided and 6.9% (4/58) of (CSPC) would have been missed. CONCLUSIONS: A combination of mpMRI and PSAD might reduce the number of biopsies performed with the cost of missing <4% of CSPC.
1st Faculty of Medicine Department of Urology Charles University Prague Czechia
2nd Faculty of Medicine Department of Urology Charles University Prague Czechia
3rd Faculty of Medicine Department of Urology Charles University Prague Czechia
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