Intravenous Thrombolysis in Posterior Circulation Stroke
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic-ecollection
Typ dokumentu časopisecké články, přehledy
PubMed
31080436
PubMed Central
PMC6497784
DOI
10.3389/fneur.2019.00417
Knihovny.cz E-zdroje
- Klíčová slova
- intracranial hemorrhage, intravenous thrombolysis, ischemia, posterior circulation, stroke,
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Background: Intravenous thrombolysis (IVT) is a standard treatment for both anterior circulation ischemic stroke (ACIS) and posterior circulation ischemic stroke (PCIS). PCIS is a clinical syndrome associated with ischemia-related changes in the territory of the posterior circulation arteries. Embolism is the most common stroke mechanism in posterior circulation. PCIS represents 12-19% of all IVT-treated strokes. Methods and Results: We searched the PubMed database for assessments of intracerebral hemorrhage (ICH) and clinical outcome in PCIS patients treated with IVT. ICH occurs in 0-6.9% of posterior ischemic stroke depending on the definition of symptomatic ICH, and any ICH in 17-23.4% of posterior ischemic stroke. For patients with PCIS, 38-49% have a favorable outcome (mRS 0-1) after IVT. Better clinical outcomes occur more often in patients with PCIS than in those with ACIS. The mortality rate among PCIS patients treated with IVT ranges from 9 to 19%; it does not differ significantly between PCIS and ACIS. Conclusions: Up to date, no data about PCIS and IVT are available from RTCs. Based on limited results from retrospective clinical studies and case series, IVT is safer for use in PCIS than in ACIS. Patients with brainstem ischemia, vertebral artery occlusion, and absence of basilar or posterior cerebral artery occlusion could be considered for treatment with IVT even in borderline cases. Time to IVT in PCIS seems to be a less crucial factor than in ACIS. IVT for PCIS may be beneficial even after 4.5 h from symptom onset.
Zobrazit více v PubMed
Mori E, Yoneda Y, Tabuchi M, Yoshida T, Ohkawa S, Ohsumi Y, et al. . Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke. Neurology. (1992) 42:976–82. 10.1212/WNL.42.5.976 PubMed DOI
Yamaguchi T, Hayakawa T, Kiuchi H. Intravenous tissue plasminogen activator ameliorates the outcome of hyperacute embolic stroke. Cerebrovasc Dis. (1993) 3:269–72. 10.1159/000108714 DOI
Haley EC, Jr, Brott TG, Sheppard GL, Barsan W, Broderick J, Marler JR, et al. . Pilot randomized trial of tissue plasminogen activator in acute ischemic stroke. The TPA Bridging Study Group. Stroke. (1993) 24:1000–4. 10.1161/01.STR.24.7.1000 PubMed DOI
National Institute of Neurological Disorders, Stroke rtPA Stroke Study Group Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. (1995) 333:1581–7. 10.1056/NEJM199512143332401 PubMed DOI
Albers GW, Clark WM, Madden KP, Hamilton SA. ATLANTIS trial: results for patients treated within 3 hours of stroke onset. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. Stroke. (2002) 33:493–5. 10.1161/hs0202.102599 PubMed DOI
Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, et al. . Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. (2008) 359:1317–29. 10.1056/NEJMoa0804656 PubMed DOI
Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, et al. . Intravenous thrombolysis with recombinant tissueplasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA. (1995) 274:1017–25. 10.1001/jama.1995.03530130023023 PubMed DOI
Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebo-controlled trial ofthrombolytic therapy with intravenous alteplase in acute ischemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet. (1998) 352:1245–51. 10.1016/S0140-6736(98)08020-9 PubMed DOI
Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA. (1999) 282:2019–26. 10.1001/jama.282.21.2019 PubMed DOI
Clark WM, Albers GW, Madden KP, Hamilton S. The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators. Stroke. (2000) 31:811–6. 10.1161/01.STR.31.4.811 PubMed DOI
Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, et al. . Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol. (2008) 7:299–309. 10.1016/S1474-4422(08)70044-9 PubMed DOI
IST-3 Collaborative Group. Sandercock P, Wardlaw JM, Lindley RI, Dennis M, Cohen G, et al. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet. (2012) 379:2352–63. 10.1016/S0140-6736(12)60768-5 PubMed DOI PMC
Merwick Á, Werring D. Posterior circulation ischemic stroke. BMJ. (2014) 348:g3175 10.1136/bmj.g3175 PubMed DOI
Gulli G, Markus HS. The use of FAST and ABCD2 scores in posterior circulation, compared with anterior circulation, stroke and transient ischemic attack. J Neurol Neurosurg Psychiatry. (2012) 83:228–9. 10.1136/jnnp.2010.222091 PubMed DOI
Gulli G, Marquardt L, Rothwell PM, Markus HS. Stroke risk after posterior circulation stroke/transient ischemic attack and its relationship to site of vertebrobasilar stenosis: pooled data analysis from prospective studies. Stroke. (2013) 44:598–604. 10.1161/STROKEAHA.112.669929 PubMed DOI
Dorňák T, Král M, Hazlinger M, Herzig R, Veverka T, Burval S, et al. . Posterior vs. anterior circulation infarction: demography, outcomes, and frequency of hemorrhage after thrombolysis. Int J Stroke. (2015) 10:1224–8. 10.1111/ijs.12626 PubMed DOI
Tao WD, Liu M, Fisher M, Wang DR, Li J, Furie KL, et al. . Posterior versus anterior circulation infarction: how different are the neurological deficits? Stroke. (2012) 43:2060–5. 10.1161/STROKEAHA.112.652420 PubMed DOI
Oppenheim C, Stanescu R, Dormont D, Crozier S, Marro B, Samson Y, et al. . False-negative diffusion-weighted MR findings in acute ischemic stroke. Am J Neuroradiol. (2000) 21:1434–40. PubMed PMC
Flossmann E, Redgrave JN, Briley D, Rothwell PM. Reliability of clinical diagnosis of the symptomatic vascular territory in patients with recent transient ischemic attack or minor stroke. Stroke. (2008) 39:2457–60. 10.1161/STROKEAHA.107.511428 PubMed DOI
Pallesen LP, Lambrou D, Eskandari A, Barlinn J, Barlinn K, Reichmann H, et al. . Perfusion computed tomography in posterior circulation stroke: predictors and prognostic implications of focal hypoperfusion. Eur J Neurol. (2018) 25:725–31. 10.1111/ene.13578 PubMed DOI
Mattle HP, Arnold M, Lindsberg PJ, Schonewille WJ, Schroth G. Basilar artery occlusion. Lancet Neurol. (2011) 10:1002–14. 10.1016/S1474-4422(11)70229-0 PubMed DOI
Marinković SV, Gibo H. The surgical anatomy of the perforating branches of the basilar artery. Neurosurgery. (1993) 33:80–7. 10.1227/00006123-199307000-00012 PubMed DOI
Frank Netter. Atlas of Human Anatomy. 6th ed. Philadelphia, PA: Saunders; (2014).
Caplan LR, Wityk RJ, Glass TA, Tapia J, Pazdera L, Chang HM, et al. New England Medical Center Posterior Circulation registry. Ann Neurol. (2004) 56:389–98. 10.1002/ana.20204 PubMed DOI
Caplan L. Posterior circulation ischemia: then, now, and tomorrow. The Thomas Willis Lecture-2000. Stroke. (2000) 31:2011–23. 10.1161/01.STR.31.8.2011 PubMed DOI
Burns JD, Rindler RS, Carr C, Lau H, Cervantes-Arslanian AM, Green-LaRoche DM, et al. . Delay in diagnosis of basilar artery stroke. Neurocrit Care. (2016) 24:172–9. 10.1007/s12028-015-0211-0 PubMed DOI
Lee JH, Han SJ, Yun YH, Choi HC, Jung S, Cho SJ, et al. . Posterior circulation ischemic stroke in Korean population. Eur J Neurol. (2006) 13:742–8. 10.1111/j.1468-1331.2006.01274.x PubMed DOI
Britt TB, Bhimji SS. Dissection, Vertebral Artery. Treasure Island, FL: StatPearls Publishing; (2018). Available online at: https://www.ncbi.nlm.nih.gov/books/NBK441827/ (accessed November 2, 2018).
Nor AM, Davis J, Sen B, Shipsey D, Louw SJ, Dyker AG, et al. . The Recognition of Stroke in the Emergency Room (ROSIER) scale: development and validation of a stroke recognition instrument. Lancet Neurol. (2005) 4:727–34. 10.1016/S1474-4422(05)70201-5 PubMed DOI
Olivato S, Nizzoli S, Cavazzuti M, Casoni F, Nichelli PF, Zini A. e-NIHSS: an expanded national institutes of health stroke scale weighted for anterior and posterior circulation strokes. J Stroke Cerebrovasc Dis. (2016) 25:2953–7. 10.1016/j.jstrokecerebrovasdis.2016.08.011 PubMed DOI
Chalela JA, Kidwell CS, Nentwich LM, Luby M, Butman JA, Demchuk AM, et al. . Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet. (2007) 369:293–8. 10.1016/S0140-6736(07)60151-2 PubMed DOI PMC
Rudkin S, Cerejo R, Tayal A, Goldberg MF. Imaging of acute ischemic stroke. Emerg Radiol. (2018) 25:659–72. 10.1007/s10140-018-1623-x PubMed DOI
Bash S, Villablanca JP, Jahan R, Duckwiler G, Tillis M, Kidwell C, et al. . Intracranial vascular stenosis and occlusive disease: evaluation with CT angiography, MR angiography, and digital subtraction angiography. Am J Neuroradiol. (2005) 26:1012–21. PubMed PMC
Boujan T, Neuberger U, Pfaff J, Nagel S, Herweh C, Bendszus M, Möhlenbruch MA. Value of contrast-enhanced MRA versus time-of-flight MRA in acute ischemic stroke MRI. Am J Neuroradiol. (2018) 39:1710–6. 10.3174/ajnr.A5771 PubMed DOI PMC
Sung SF, Chen CH, Chen YW, Tseng MC, Shen HC, Lin HJ. Predicting symptomatic intracerebral hemorrhage after intravenous thrombolysis: stroke territory as a potential pitfall. J Neurol Sci. (2013) 335:96–100. 10.1016/j.jns.2013.08.036 PubMed DOI
Sarikaya H, Arnold M, Engelter ST, Lyrer PA, Mattle HP, Georgiadis D, et al. . Outcomes of intravenous thrombolysis in posterior versus anterior circulation stroke. Stroke. (2011) 42:2498–502. 10.1161/STROKEAHA.110.607614 PubMed DOI
Förster A, Gass A, Kern R, Griebe M, Hennerici MG, Szabo K. Thrombolysis in posterior circulation stroke: stroke subtypes and patterns, complications and outcome. Cerebrovasc Dis. (2011) 32:349–53. 10.1159/000330346 PubMed DOI
Valentino F, Gentile L, Terruso V, Mastrilli S, Aridon P, Ragonese P, et al. . Frequency and determinants for hemorrhagic transformation of posterior cerebral stroke : posterior ischemic stroke and hemorrhagic transformation. BMC Res Notes. (2017) 10:592. 10.1186/s13104-017-2889-x PubMed DOI PMC
Tsao JW, Hemphill JC III, Johnston SC, Smith WS, Bonovich DC. Initial Glasgow Coma Scale score predicts outcome following thrombolysis for posterior circulation stroke. Arch Neurol. (2005) 62:1126–9. 10.1001/archneur.62.7.1126 PubMed DOI
Rao NM, Levine SR, Gornbein JA, Saver JL. Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the National Institute of Neurological Disorders and Stroke tissue-type plasminogen activator trials. Stroke. (2014) 45:2728–33. 10.1161/STROKEAHA.114.005135 PubMed DOI PMC
Sato S, Toyoda K, Uehara T, Toratani N, Yokota C, Moriwaki H, et al. . Baseline NIH Stroke Scale Score predicting outcome in anterior and posterior circulation strokes. Neurology. (2008) 70:2371–7. 10.1212/01.wnl.0000304346.14354.0b PubMed DOI
Lindgren A, Norrving B, Rudling O, Johansson BB. Comparison of clinical and neuroradiological findings in first-ever stroke. A population-based study. Stroke. (1994) 25:1371–7. PubMed
Menon BK, O'Brien B, Bivard A, Spratt NJ, Demchuk AM, Miteff F, et al. . Assessment of leptomeningeal collaterals using dynamic CT angiography in patients with acute ischemic stroke. J Cereb Blood Flow Metab. (2013) 33:365–71. 10.1038/jcbfm.2012.171 PubMed DOI PMC
Lee M, Saver JL, Alger JR, Hao Q, Starkman S, Ali LK, et al. . Blood-brain barrier permeability derangements in posterior circulation ischemic stroke: frequency and relation to hemorrhagic transformation. J Neurol Sci. (2012) 313:142–6. 10.1016/j.jns.2011.08.048 PubMed DOI PMC
Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. . 2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. (2018) 49:e46–110. 10.1161/STR.0000000000000158 PubMed DOI
Sung SF, Chen SC, Lin HJ, Chen YW, Tseng MC, Chen CH. Comparison of risk-scoring systems in predicting symptomatic intracerebral hemorrhage after intravenous thrombolysis. Stroke. (2013) 44:1561–6. 10.1161/STROKEAHA.111.000651 PubMed DOI
Asuzu D, Nystrom K, Amin H, Schindler J, Wira C, Greer D, et al. . Comparison of 8 scores for predicting symptomatic intracerebral hemorrhage after IV thrombolysis. Neurocrit Care. (2015) 22:229–33. 10.1007/s12028-014-0060-2 PubMed DOI
Tong X, Liao X, Pan Y, Cao Y, Wang C, Liu L, et al. . Intravenous thrombolysis is more safe and effective for posterior circulation stroke: data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China). Medicine. (2016) 95:e3848. 10.1097/MD.0000000000003848 PubMed DOI PMC
Dorňák T, Král M, Sedláčková Z, Šanák D, Cecháková E, Divišová P, et al. Predictors for intracranial hemorrhage following intravenous thrombolysis in posterior circulation stroke. Transl Stroke Res. (2018) 9:582–8. 10.1007/s12975-018-0608-0 PubMed DOI
Dorňák T, Herzig R, Šanák D, Školoudík D. Management of acute basilar artery occlusion: should any treatment strategy prevail? Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. (2014) 58:528–34. 10.5507/bp.2013.075 PubMed DOI
Montavont A, Nighoghossian N, Derex L, Hermier M, Honnorat J, Philippeau F, et al. . Intravenous r-TPA in vertebrobasilar acute infarcts. Neurology. (2004) 62:1854–6. 10.1212/01.WNL.0000125330.06520.0D PubMed DOI
Picanço MR, Christensen S, Campbell BC, Churilov L, Parsons MW, Desmond PM, et al. . Reperfusion after 4.5 hours reduces infarct growth and improves clinical outcomes. Int J Stroke. (2014) 9:266–9. 10.1111/ijs.12209 PubMed DOI
Schonewille WJ, Wijman CA, Michel P, Rueckert CM, Weimar C, Mattle HP, et al. . Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study. Lancet Neurol. (2009) 8:724–30. 10.1016/S1474-4422(09)70173-5 PubMed DOI
Brandt T, von Kummer R, Müller-Küppers M, Hacke W. Thrombolytic therapy of acute basilar artery occlusion. Variables affecting recanalization and outcome. Stroke. (1996) 27:875–81. PubMed
Jung S, Mono ML, Fischer U, Galimanis A, Findling O, De Marchis GM, et al. . Three-month and long-term outcomes and their predictors in acute basilar artery occlusion treated with intra-arterial thrombolysis. Stroke. (2011) 42:1946–51. 10.1161/STROKEAHA.110.606038 PubMed DOI
Sairanen T, Strbian D, Soinne L, Silvennoinen H, Salonen O, Artto V, et al. . Intravenous thrombolysis of basilar artery occlusion: predictors of recanalization and outcome. Stroke. (2011) 42:2175–9. 10.1161/STROKEAHA.110.605584 PubMed DOI
Dorňák T, Herzig R, Kuliha M, Havlíček R, Školoudík D, Šanák D, et al. . Endovascular treatment of acute basilar artery occlusion: time to treatment is crucial. Clin Radiol. (2015) 70:e20–7. 10.1016/j.crad.2015.01.008 PubMed DOI
Mazighi M, Meseguer E, Labreuche J, Amarenco P. Bridging therapy in acute ischemic stroke: a systematic review and meta-analysis. Stroke. (2012) 43:1302–8. 10.1161/STROKEAHA.111.635029 PubMed DOI
Dorňák T, Herzig R, Školoudík D, Šanák D, Kuliha M, Roubec M, et al. . Outcome predictors in acute basilar artery occlusion. Can J Neurol Sci. (2014) 41:368–74. 10.1017/S0317167100017327 PubMed DOI
Pfefferkorn T, Holtmannspötter M, Schmidt C, Bender A, Pfister HW, Straube A, et al. . Drip, ship, and retrieve: cooperative recanalization therapy in acute basilar artery occlusion. Stroke. (2010) 41:722–6. 10.1161/STROKEAHA.109.567552 PubMed DOI