Enzymes of microbial origin are of immense importance for organic material decomposition leading to bioremediation of organic waste, bioenergy generation, large-scale industrial bioprocesses, etc. The market demand for microbial cellulase enzyme is growing more rapidly which ultimately becomes the driving force towards research on this biocatalyst, widely used in various industrial activities. The use of novel cellulase genes obtained from various thermophiles through metagenomics and genetic engineering as well as following metabolic engineering pathways would be able to enhance the production of thermophilic cellulase at industrial scale. The present review is mainly focused on thermophilic cellulolytic bacteria, discoveries on cellulase gene, genetically modified cellulase, metabolic engineering, and their various industrial applications. A lot of lacunae are yet to overcome for thermophiles such as metagenome analysis, metabolic pathway modification study, search of heterologous hosts in gene expression system, and improved recombinant strain for better cellulase yield as well as value-added product formation.

Biomics and Biodiversity Lab Centre of Biotechnology Siksha 'O' Anusandhan Bhubaneswar Odisha 751003 India

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Int J Biol Sci. 2009 Jul 29;5(5):500-16 PubMed

Curr Opin Chem Biol. 2001 Apr;5(2):144-51 PubMed

J Biotechnol. 2000 Oct 13;83(3):177-87 PubMed

Curr Microbiol. 2008 Nov;57(5):503-7 PubMed

Bioresour Technol. 2013 Jan;128:751-9 PubMed

Biotechnol Lett. 2015 Jun;37(6):1117-29 PubMed

Appl Environ Microbiol. 2002 Jan;68(1):297-305 PubMed

Appl Environ Microbiol. 1986 Oct;52(4):737-43 PubMed

Bioresour Technol. 2011 Sep;102(18):8357-67 PubMed

Curr Opin Chem Biol. 1999 Feb;3(1):39-46 PubMed

Biotechnol Lett. 2017 Jan;39(1):123-131 PubMed

Microb Cell Fact. 2011 Dec 06;10:103 PubMed

Appl Environ Microbiol. 2011 Dec;77(23):8288-94 PubMed

J Appl Microbiol. 2006 Jun;100(6):1208-19 PubMed

J Bacteriol. 2011 Jun;193(11):2906-7 PubMed

Microbiology. 1998 Feb;144 ( Pt 2):457-65 PubMed

Appl Environ Microbiol. 1995 Apr;61(4):1399-407 PubMed

3 Biotech. 2017 May;7(1):14 PubMed

J Clin Microbiol. 1997 May;35(5):1071-6 PubMed

Appl Biochem Biotechnol. 2010 May;161(1-8):301-12 PubMed

Bioresour Technol. 2010 Dec;101(23):9150-5 PubMed

BMC Biotechnol. 2015 Mar 19;15:19 PubMed

J Agric Food Chem. 2006 May 31;54(11):3840-51 PubMed

Science. 2011 Jan 28;331(6016):463-7 PubMed

FEMS Microbiol Lett. 2014 Feb;351(2):147-55 PubMed

Biochem J. 2005 Jan 15;385(Pt 2):581-8 PubMed

J Agric Food Chem. 1974 May-Jun;22(3):523-6 PubMed

Plasmid. 2003 Jan;49(1):2-8 PubMed

Trends Biotechnol. 2012 Feb;30(2):111-9 PubMed

Microb Cell Fact. 2005 Mar 25;4(1):8 PubMed

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13769-74 PubMed

Methods Mol Biol. 2009;581:213-31 PubMed

mBio. 2016 Aug 23;7(4): PubMed

Gene. 2013 May 1;519(2):360-6 PubMed

Methods Enzymol. 2012;510:261-71 PubMed

J Appl Microbiol. 2009 Dec 1;107(6):2098-107 PubMed

PLoS One. 2015 Mar 13;10(3):e0119917 PubMed

mBio. 2010 Dec 14;1(5):null PubMed

Biochemistry. 1996 Aug 20;35(33):10648-60 PubMed

Eur J Biochem. 1993 Apr 1;213(1):305-12 PubMed

Genome Announc. 2015 Feb 19;3(1):null PubMed

Huan Jing Ke Xue. 2010 Aug;31(8):1926-31 PubMed

Appl Biochem Biotechnol. 2010 May;161(1-8):147-56 PubMed

Bioprocess Biosyst Eng. 2016 Jan;39(1):181-91 PubMed

Braz J Microbiol. 2012 Jul;43(3):844-56 PubMed

Biotechnology (N Y). 1993 Mar;11(3):376-9 PubMed

BMC Microbiol. 2011 Jun 14;11:134 PubMed

Sci Rep. 2016 Dec 12;6:38915 PubMed

Appl Environ Microbiol. 2011 Feb;77(4):1436-42 PubMed

J Biotechnol. 2006 Oct 20;126(1):26-36 PubMed

Biomolecules. 2014 Jan 16;4(1):117-39 PubMed

FEMS Microbiol Lett. 2013 Feb;339(2):93-101 PubMed

Asian-Australas J Anim Sci. 2013 Jan;26(1):50-8 PubMed

Lett Appl Microbiol. 2014 Sep;59(3):306-12 PubMed

Arch Microbiol. 1997 Aug;168(2):114-9 PubMed

Microbiol Mol Biol Rev. 2001 Mar;65(1):1-43 PubMed

PLoS One. 2013 Dec 17;8(12):e83635 PubMed

Biotechnol Adv. 2013 Nov;31(6):827-37 PubMed

J Bacteriol. 2012 Sep;194(18):5091-100 PubMed

Sci Rep. 2014 Oct 21;4:6708 PubMed

Enzyme Res. 2011;2011:151656 PubMed

3 Biotech. 2014 Aug;4(4):411-424 PubMed

Appl Environ Microbiol. 1998 Dec;64(12):4774-81 PubMed

Biochem J. 1992 Apr 1;283 ( Pt 1):69-73 PubMed

Metab Eng. 2010 Jul;12(4):307-31 PubMed

J Dairy Sci. 2003 Feb;86(2):630-43 PubMed

Adv Biochem Eng Biotechnol. 2017;160:103-119 PubMed

PLoS One. 2016 Mar 17;11(3):e0147485 PubMed

FEMS Microbiol Lett. 2008 May;282(1):44-51 PubMed

Environ Microbiol. 2013 Sep;15(9):2573-87 PubMed

Springerplus. 2014 Jul 16;3:365 PubMed

Genome Res. 2009 Jun;19(6):1033-43 PubMed

Biotechnol Biofuels. 2016 Jul 04;9:138 PubMed

Biotechnol Biofuels. 2014 Oct 18;7(1):135 PubMed

Biotechnol Lett. 2007 Jun;29(6):931-6 PubMed

PLoS One. 2013 Jun 13;8(6):e65727 PubMed

Appl Microbiol. 1972 Jul;24(1):83-90 PubMed

Appl Environ Microbiol. 2002 Jan;68(1):430-3 PubMed

Appl Environ Microbiol. 2010 Jun;76(11):3545-53 PubMed

Comput Struct Biotechnol J. 2012 Nov 08;3:e201210007 PubMed

Front Microbiol. 2015 Nov 05;6:1209 PubMed

Folia Microbiol (Praha). 2017 May;62(3):175-181 PubMed

Biotechnol Biofuels. 2012 Jan 04;5(1):2 PubMed

Trends Biotechnol. 2008 Sep;26(9):483-9 PubMed

Bioresour Technol. 2003 Aug;89(1):17-34 PubMed

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8931-6 PubMed

Appl Environ Microbiol. 2010 Feb;76(4):1014-20 PubMed

FEMS Microbiol Lett. 2007 Mar;268(2):194-201 PubMed

Appl Biochem Biotechnol. 2002 Spring;98-100:273-87 PubMed

Eur J Biochem. 1991 Sep 1;200(2):379-85 PubMed

Appl Microbiol Biotechnol. 1995 May-Jun;43(2):291-6 PubMed

Trends Biotechnol. 2013 Oct;31(10):581-93 PubMed

Int J Food Microbiol. 2005 Feb 15;98(3):301-8 PubMed

Adv Appl Microbiol. 2010;70:1-55 PubMed

Biochemistry. 2000 May 2;39(17):4963-70 PubMed

Biotechnol Biofuels. 2016 Jul 08;9:140 PubMed

Carbohydr Polym. 2013 Apr 15;94(1):409-15 PubMed

FEMS Microbiol Rev. 2013 Mar;37(2):182-203 PubMed

Antonie Van Leeuwenhoek. 1995 Nov;68(4):263-71 PubMed

BMC Res Notes. 2012 Oct 13;5:566 PubMed

Front Bioeng Biotechnol. 2015 Jul 01;3:95 PubMed

Braz J Microbiol. 2015 Oct-Dec;46(4):1225-34 PubMed

J Appl Microbiol. 2009 Jul;107(1):245-56 PubMed

Mol Microbiol. 2011 Aug;81(4):897-911 PubMed

Curr Opin Biotechnol. 2006 Jun;17(3):250-5 PubMed

Asian-Australas J Anim Sci. 2015 Feb;28(2):231-8 PubMed

Appl Biochem Biotechnol. 2012 Dec;168(7):1834-48 PubMed

J Appl Microbiol. 2013 Apr;114(4):1001-7 PubMed

Curr Microbiol. 2008 Jul;57(1):39-44 PubMed

Biotechnol Biofuels. 2016 Aug 04;9:164 PubMed

Biotechnol Biofuels. 2016 Jan 29;9:22 PubMed

PLoS One. 2012;7(5):e37010 PubMed

Appl Microbiol Biotechnol. 1998 Mar;49(3):277-84 PubMed

Biotechnol Adv. 2006 Sep-Oct;24(5):452-81 PubMed

Curr Opin Chem Eng. 2012 Nov 12;1(4):363-372 PubMed

Enzyme Res. 2011;2011:280696 PubMed

FEMS Microbiol Lett. 2006 Nov;264(2):226-31 PubMed

Appl Environ Microbiol. 1986 Jun;51(6):1293-9 PubMed

Int J Syst Evol Microbiol. 2011 Nov;61(Pt 11):2697-701 PubMed

J Ind Microbiol Biotechnol. 2012 Sep;39(9):1301-7 PubMed

Metab Eng. 2009 Nov;11(6):398-408 PubMed

Biomed Res Int. 2014;2014:512497 PubMed

Mol Biotechnol. 2008 Oct;40(2):195-201 PubMed

J Bacteriol. 2002 Mar;184(5):1378-84 PubMed

Biochem J. 1991 Aug 1;277 ( Pt 3):887-90 PubMed

Front Biosci. 2000 Sep 01;5:D780-6 PubMed

Biotechnol Prog. 1999 Mar;15(2):147-57 PubMed