T cells in swine completely rearrange immunoglobulin heavy chain genes
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
31125574
DOI
10.1016/j.dci.2019.103396
PII: S0145-305X(19)30149-1
Knihovny.cz E-zdroje
- Klíčová slova
- B cell receptors, Gene rearrangement, Lymphocyte repertoire development, Lymphocyte subpopulations, Porcine immune system, Thymus,
- MeSH
- B-lymfocyty imunologie MeSH
- druhová specificita MeSH
- geny pro těžké řetězce imunoglobulinů genetika MeSH
- lidé MeSH
- plod imunologie MeSH
- podskupiny lymfocytů imunologie MeSH
- prasata genetika růst a vývoj imunologie MeSH
- T-lymfocyty imunologie MeSH
- thymus růst a vývoj imunologie MeSH
- V(D)J rekombinace genetika MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
Porcine thymus contains three independent populations of cells that have rearranged immunoglobulin heavy chain VDJH genes. The first population can be found exclusively in medulla and it consists of existing mature B cells and plasma cells. The second consists of developing B cells characterized by the presence of selected VDJH rearrangement, similar to B cell lymphogenesis in the bone marrow. The third population is entirely unaffected by selection mechanism for productive VDJH rearrangement and represents T lineage cells that rearrange immunoglobulin genes. Transcription of unselected VDJH repertoire is not allowed in T cells. Sequence analysis of unselected VDJH repertoire from T cells also revealed important consequences for B cell lymphogenesis and selection of B cell repertoire. As far as we know, this is the first evidence that some species completely rearrange VDJH genes in T cells. Our results also support the finding that B cells actively develop in the thymus.
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