Polyaniline colloids stabilized with bioactive polysaccharides: Non-cytotoxic antibacterial materials
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články
PubMed
31151543
DOI
10.1016/j.carbpol.2019.05.038
PII: S0144-8617(19)30546-6
Knihovny.cz E-zdroje
- Klíčová slova
- Antibacterial effect, Chitosan, Colloid, Cytotoxicity, Polyaniline, Sodium hyaluronate,
- MeSH
- aniliny * chemie farmakologie MeSH
- antibakteriální látky farmakologie MeSH
- buňky NIH 3T3 MeSH
- chitosan chemie MeSH
- Escherichia coli účinky léků MeSH
- koloidy * chemie farmakologie MeSH
- kyselina hyaluronová chemie MeSH
- myši MeSH
- nanokompozity chemie MeSH
- Staphylococcus aureus účinky léků MeSH
- viabilita buněk účinky léků MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- aniliny * MeSH
- antibakteriální látky MeSH
- chitosan MeSH
- koloidy * MeSH
- kyselina hyaluronová MeSH
- polyaniline MeSH Prohlížeč
Colloidal polyaniline dispersions stabilized with biocompatible polysaccharides, sodium hyaluronate and chitosan (both with two different molecular weights), were successfully formulated. The colloids were characterized by UV-vis spectra, particle-size distributions and morphology, as well as by their biological properties in terms of cytotoxicity and antibacterial activity. Colloids containing both chitosan and hyaluronate showed only mild cytotoxicities, which were mainly governed by the concentration of conducting polyaniline in the colloid. Antibacterial activity of the samples, however, depended both on the type of polysaccharide and the ratio between the stabilizer and polyaniline mass. The colloid synthetized using 0.2 M aniline hydrochloride, 0.1 M ammonium persulfate, and 1 wt.% sodium hyaluronate of molecular weight of 1.8-2.1 × 106 exhibited the highest antibacterial activity against both gram positive and gram negative bacteria. This formulation, therefore, allowed for the formation of potentially stimuli-responsive antibacterial colloidal particles with low cytotoxicity.
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