Polyaniline colloids stabilized with bioactive polysaccharides: Non-cytotoxic antibacterial materials
Language English Country England, Great Britain Media print-electronic
Document type Comparative Study, Journal Article
PubMed
31151543
DOI
10.1016/j.carbpol.2019.05.038
PII: S0144-8617(19)30546-6
Knihovny.cz E-resources
- Keywords
- Antibacterial effect, Chitosan, Colloid, Cytotoxicity, Polyaniline, Sodium hyaluronate,
- MeSH
- Aniline Compounds * chemistry pharmacology MeSH
- Anti-Bacterial Agents pharmacology MeSH
- NIH 3T3 Cells MeSH
- Chitosan chemistry MeSH
- Escherichia coli drug effects MeSH
- Colloids * chemistry pharmacology MeSH
- Hyaluronic Acid chemistry MeSH
- Mice MeSH
- Nanocomposites chemistry MeSH
- Staphylococcus aureus drug effects MeSH
- Cell Survival drug effects MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Aniline Compounds * MeSH
- Anti-Bacterial Agents MeSH
- Chitosan MeSH
- Colloids * MeSH
- Hyaluronic Acid MeSH
- polyaniline MeSH Browser
Colloidal polyaniline dispersions stabilized with biocompatible polysaccharides, sodium hyaluronate and chitosan (both with two different molecular weights), were successfully formulated. The colloids were characterized by UV-vis spectra, particle-size distributions and morphology, as well as by their biological properties in terms of cytotoxicity and antibacterial activity. Colloids containing both chitosan and hyaluronate showed only mild cytotoxicities, which were mainly governed by the concentration of conducting polyaniline in the colloid. Antibacterial activity of the samples, however, depended both on the type of polysaccharide and the ratio between the stabilizer and polyaniline mass. The colloid synthetized using 0.2 M aniline hydrochloride, 0.1 M ammonium persulfate, and 1 wt.% sodium hyaluronate of molecular weight of 1.8-2.1 × 106 exhibited the highest antibacterial activity against both gram positive and gram negative bacteria. This formulation, therefore, allowed for the formation of potentially stimuli-responsive antibacterial colloidal particles with low cytotoxicity.
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