Overexpression of Galectin-3 in Chronic Lymphocytic Leukemia Is Associated With 17p Deletion: A Short Report
Language English Country Greece Media print
Document type Journal Article
PubMed
31177117
DOI
10.21873/anticanres.13408
PII: 39/6/2805
Knihovny.cz E-resources
- Keywords
- 17p deletion, B-cells, Galectin-3, chronic lymphocytic leukemia, cytogenetics, flow cytometry,
- MeSH
- Chromosome Deletion * MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell genetics MeSH
- Cytoplasm metabolism MeSH
- Adult MeSH
- Galectin 3 genetics MeSH
- Galectins MeSH
- Blood Proteins MeSH
- Middle Aged MeSH
- Humans MeSH
- Chromosomes, Human, Pair 17 genetics MeSH
- Biomarkers, Tumor genetics MeSH
- Prognosis MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Up-Regulation * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Galectin 3 MeSH
- Galectins MeSH
- Blood Proteins MeSH
- LGALS3 protein, human MeSH Browser
- Biomarkers, Tumor MeSH
BACKGROUND/AIM: Galectins belong to the family of galactose-binding proteins known to play an important role in the processes of cell proliferation, differentiation, migration and neoplastic progression. Herein, we studied the expression of galectin-3 (Gal-3) in chronic lymphocytic leukemia (CLL). MATERIALS AND METHODS: The expression of Gal-3 was analyzed by means of multiparametric flow cytometry in normal and pathological B-cells from peripheral blood and bone marrow samples of 67 patients with CLL. RESULTS: Pathological B-cells expressed significantly higher levels of cytoplasmic Gal-3 than normal B-cells. Moreover, overexpression of cytoplasmic Gal-3 was observed in the prognostically poorest subgroup of CLL patients, namely those with 17p deletion. CONCLUSION: Our results indicate a possible role of galectin-3 in CLL pathophysiology and its potential value as a prognostic marker and therapeutic target.
Department of Clinical Genetics Medirex a s Kosice Slovak Republic
Department of Pharmacology Faculty of Medicine P J Safarik University Kosice Slovak Republic
Laboratory of Cell Interactions MediPark P J Safarik University Kosice Slovak Republic
Prague Burn Centre 3rd Faculty of Medicine Charles University Prague Czech Republic
References provided by Crossref.org
