Overexpression of Galectin-3 in Chronic Lymphocytic Leukemia Is Associated With 17p Deletion: A Short Report
Jazyk angličtina Země Řecko Médium print
Typ dokumentu časopisecké články
PubMed
31177117
DOI
10.21873/anticanres.13408
PII: 39/6/2805
Knihovny.cz E-zdroje
- Klíčová slova
- 17p deletion, B-cells, Galectin-3, chronic lymphocytic leukemia, cytogenetics, flow cytometry,
- MeSH
- chromozomální delece * MeSH
- chronická lymfatická leukemie genetika MeSH
- cytoplazma metabolismus MeSH
- dospělí MeSH
- galektin 3 genetika MeSH
- galektiny MeSH
- krevní proteiny MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidské chromozomy, pár 17 genetika MeSH
- nádorové biomarkery genetika MeSH
- prognóza MeSH
- regulace genové exprese u nádorů MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- upregulace * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- galektin 3 MeSH
- galektiny MeSH
- krevní proteiny MeSH
- LGALS3 protein, human MeSH Prohlížeč
- nádorové biomarkery MeSH
BACKGROUND/AIM: Galectins belong to the family of galactose-binding proteins known to play an important role in the processes of cell proliferation, differentiation, migration and neoplastic progression. Herein, we studied the expression of galectin-3 (Gal-3) in chronic lymphocytic leukemia (CLL). MATERIALS AND METHODS: The expression of Gal-3 was analyzed by means of multiparametric flow cytometry in normal and pathological B-cells from peripheral blood and bone marrow samples of 67 patients with CLL. RESULTS: Pathological B-cells expressed significantly higher levels of cytoplasmic Gal-3 than normal B-cells. Moreover, overexpression of cytoplasmic Gal-3 was observed in the prognostically poorest subgroup of CLL patients, namely those with 17p deletion. CONCLUSION: Our results indicate a possible role of galectin-3 in CLL pathophysiology and its potential value as a prognostic marker and therapeutic target.
Department of Clinical Genetics Medirex a s Kosice Slovak Republic
Department of Pharmacology Faculty of Medicine P J Safarik University Kosice Slovak Republic
Laboratory of Cell Interactions MediPark P J Safarik University Kosice Slovak Republic
Prague Burn Centre 3rd Faculty of Medicine Charles University Prague Czech Republic
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