G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.

Equipe labellisée par la Ligue contre le cancer Université Paris Descartes Université Sorbonne Paris Cité Université Paris Diderot Sorbonne Université INSERM U1138 Centre de Recherche des Cordeliers Paris France

INSERM U1218 Institut Bergonié Université de Bordeaux Bordeaux France

Institut Curie PSL Research University CNRS UMR 9187 INSERM U1196 Orsay France

Institute of Biophysics of the Czech Academy of Sciences Brno Czech Republic

Metabolomics and Cell Biology Platforms Institut Gustave Roussy Villejuif France

Université de Bordeaux INSERM U1212 CNRS UMR 5320 ARNA Laboratory IECB Pessac France

Université Paris Sud Université Paris Saclay CNRS UMR 9187 INSERM U1196 Orsay France

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G-quadruplex ligands as potent regulators of lysosomes