Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study
Jazyk angličtina Médium print-electronic
Typ dokumentu časopisecké články, randomizované kontrolované studie
PubMed
39954533
PubMed Central
PMC12179999
DOI
10.1016/j.jnha.2025.100512
PII: S1279-7707(25)00035-1
Knihovny.cz E-zdroje
- Klíčová slova
- Clinical trial, Diabetes, Frailty, Functional impairment, Older people,
- MeSH
- diabetes mellitus 2. typu * terapie komplikace patofyziologie MeSH
- geriatrické hodnocení MeSH
- křehkost * terapie MeSH
- křehký senior * MeSH
- lidé MeSH
- odporový trénink MeSH
- samostatný způsob života MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- tělesná a funkční výkonnost * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
AIMS: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after ≥18 months of intervention. METHODS: 298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18-24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). RESULTS: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried's frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3-5.4; p = 0.009 and OR 1.9; 95%CI 1.1-3.1; p = 0.02, respectively). IG participants more frequently improved ≥1 point in SPPB score (OR 1.85; 95%CI 1.09-3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. CONCLUSIONS: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.
1st Faculty of Medicine Charles University Prague Czech Republic
Centre Hospitalier Universitaire de Bordeaux Bordeaux France
Centre Hospitalier Universitaire de Toulouse Toulouse France
Foundation for Biomedical Research University Hospital of Getafe Madrid Spain
IdiSNA Navarra Institute for Health Research Public University of Navarra Pamplona Spain
Zobrazit více v PubMed
Rodriguez-Mañas L., Laosa O., Vellas B., Paolisso G., Topinkova E., Oliva-Moreno J., et al. Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus. J Cachexia Sarcopenia Muscle. 2019;10(4):721–733. PubMed PMC
Verghese J., Ayers E., Sathyan S., Lipton R.B., Milman S., Barzilai N., et al. Trajectories of frailty in aging: prospective cohort study. PloS One. 2021;16(7) PubMed PMC
Rodríguez-Laso Á, García-García F.J., Rodríguez-Mañas L. Transitions between frailty states and its predictors in a cohort of community-dwelling spaniards. J Am Med Dir Assoc. 2022;23(3):524.e1–524.e11. PubMed
Ye B., Chen H., Huang L., Ruan Y., Qi S., Guo Y., et al. Changes in frailty among community-dwelling Chinese older adults and its predictors: evidence from a two-year longitudinal study. BMC Geriatr. 2020;20(1):130. PubMed PMC
Álvarez-Bustos A., Carnicero-Carreño J.A., Sanchez-Sanchez J.L., Garcia-Garcia F.J., Alonso-Bouzón C., Rodríguez-Mañas L. Associations between frailty trajectories and frailty status and adverse outcomes in community-dwelling older adults. J Cachexia Sarcopenia Muscle. 2022;13(1):230–239. Epub 2021 Dec 23. PubMed PMC
Izquierdo M., Laosa O., Cadore E.L., Abizanda P., Garcia-Garcia F.J., Hornillos M., et al. Two-year follow-up of a multimodal intervention on functional capacity and muscle power in frail patients with type 2 diabetes. J Am Med Dir Assoc. 2021;22(9):1906–1911. PubMed
Rodríguez-Mañas L., Bayer A.J., Kelly M., Zeyfang A., Izquierdo M., Laosa O., et al. An evaluation of the effectiveness of a multi-modal intervention in Frail and pre-Frail older people with type 2 diabetes--the MID-Frail study: study protocol for a randomised controlled trial. Trials. 2014;15:34. PubMed PMC
Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J., et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–156. PubMed
Folstein M.F., Folstein S.E., McHugh P.R. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198. PubMed
Mahoney F.I., Barthel D.W. Functional evaluation: the barthel index. Md State Med J. 1965;14:61–65. PubMed
Ibañez J., Izquierdo M., Argüelles I., Forga L., Larrión J.L., García-Unciti M., et al. Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care. 2005;28(3):662–667. PubMed
Sinclair A.J., Paolisso G., Castro M., Bourdel-Marchasson I., Gadsby R., Rodriguez Mañas L., et al. European diabetes working party for older people 2011 clinical guidelines for type 2 diabetes mellitus. Executive summary. Diabetes Metab. 2011;37(Suppl 3):S27–38. PubMed
Sterne J.A.C., White I.R., Carlin J.B., Spratt M., Royston P., Kenward M.G., et al. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ. 2009;338 PubMed PMC
Gill T.M., Gahbauer E.A., Allore H.G., Han L. Transitions between frailty states among community-living older persons. Arch Intern Med. 2006;166(4):418–423. PubMed
Sanchez-Sanchez J.L., Izquierdo M., Carnicero-Carreño J.A., García-García F.J., Rodríguez-Mañas L. Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging. J Cachexia Sarcopenia Muscle. 2020;11(4):1007–1017. PubMed PMC
Sinclair A.J., Laosa O., Antonio Carnicero J., Rodriguez-Mañas L., Álvarez-Bustos A. Disability and quality of life measures in older frail and prefrail people with type 2 diabetes. The MIDFRAIL-study. Diabetes Res Clin Pract [Internet] 2024:214. doi: 10.1016/j.diabres.2024.111797. Available from: PubMed DOI
Sirven N., Rapp T. The cost of frailty in France. Eur J Health Econ HEPAC Health Econ Prev Care. 2017;18(2):243–253. PubMed
Ensrud K.E., Schousboe J.T., Kats A.M., Taylor B.C., Boyd C.M., Langsetmo L. Incremental health care costs of self-reported functional impairments and phenotypic frailty in community-dwelling older adults: a prospective cohort study. Ann Intern Med. 2023;176(4):463–471. PubMed PMC
Peña-Longobardo L.M., Oliva-Moreno J., Zozaya N., Aranda-Reneo I., Trapero-Bertran M., Laosa O., et al. Economic evaluation of a multimodal intervention in pre-frail and frail older people with diabetes mellitus: the MID-FRAIL project. Expert Rev Pharmacoecon Outcomes Res. 2021;21(1):111–118. PubMed
SPRINTT consortium. Rapp T., Sicsic J., Ronchetti J., Cicchetti A. Preventing autonomy loss with multicomponent geriatric interventions: a resource-saving strategy? Evidence from the SPRINT-T study. SSM - Popul Health. 2023;24 PubMed PMC
Ramirez-Campillo R., Diaz D., Martinez-Salazar C., Valdés-Badilla P., Delgado-Floody P., Méndez-Rebolledo G., et al. Effects of different doses of high-speed resistance training on physical performance and quality of life in older women: a randomized controlled trial. Clin Interv Aging. 2016;11:1797–1804. PubMed PMC
Cadore E.L., Rodríguez-Mañas L., Sinclair A., Izquierdo M. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. Rejuvenation Res. 2013;16(2):105–114. PubMed PMC
Pahor M., Guralnik J.M., Ambrosius W.T., Blair S., Bonds D.E., Church T.S., et al. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311(23):2387–2396. PubMed PMC
Bernabei R., Landi F., Calvani R., Cesari M., Del Signore S., Anker S.D., et al. Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project) BMJ. 2022;377 PubMed PMC
Álvarez-Bustos A., Laosa O., Marzetti E., Carnicero J.A., Castro-Rodriguez M., Landi F., et al. Response rates and associated factors after a multicomponent intervention in frail older adults with diabetes. Age Ageing. 2024;53(1) PubMed
Trombetti A., Hars M., Hsu F.C., Reid K.F., Church T.S., Gill T.M., et al. Effect of physical activity on frailty: secondary analysis of a randomized controlled trial. Ann Intern Med. 2018;168(5):309–316. PubMed PMC
Cesari M., Vellas B., Hsu F.C., Newman A.B., Doss H., King A.C., et al. A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. J Gerontol A Biol Sci Med Sci. 2015;70(2):216–222. PubMed PMC
Haider S., Grabovac I., Dorner T.E. Effects of physical activity interventions in frail and prefrail community-dwelling people on frailty status, muscle strength, physical performance and muscle mass-a narrative review. Wien Klin Wochenschr. 2019;131(11–12):244–254. PubMed PMC
Pérez-Rodríguez R., Guevara-Guevara T., Moreno-Sánchez P.A., Villalba-Mora E., Valdés-Aragonés M., Oviedo-Briones M., et al. Monitoring and intervention technologies to manage diabetic older persons: the CAPACITY case-A pilot study. Front Endocrinol. 2020;11:300. PubMed PMC
Tarazona-Santabalbina F.J., Gómez-Cabrera M.C., Pérez-Ros P., Martínez-Arnau F.M., Cabo H., Tsaparas K., et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17(5):426–433. PubMed
Losa-Reyna J., Baltasar-Fernandez I., Alcazar J., Navarro-Cruz R., Garcia-Garcia F.J., Alegre L.M., et al. Effect of a short multicomponent exercise intervention focused on muscle power in frail and pre frail elderly: a pilot trial. Exp Gerontol. 2019;115:114–121. PubMed
Cameron I.D., Fairhall N., Langron C., Lockwood K., Monaghan N., Aggar C., et al. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Med. 2013;11:65. PubMed PMC
García-Esquinas E., Graciani A., Guallar-Castillón P., López-García E., Rodríguez-Mañas L., Rodríguez-Artalejo F. Diabetes and risk of frailty and its potential mechanisms: a prospective cohort study of older adults. J Am Med Dir Assoc. 2015;16(9):748–754. PubMed
Castro-Rodríguez M., Carnicero J.A., Garcia-Garcia F.J., Walter S., Morley J.E., Rodríguez-Artalejo F., et al. Frailty as a major factor in the increased risk of death and disability in older people with diabetes. J Am Med Dir Assoc. 2016;17(10):949–955. PubMed
Bourdel-Marchasson I., Maggi S., Abdelhafiz A., Bellary S., Demurtas J., Forbes A., et al. Essential steps in primary care management of older people with Type 2 diabetes: an executive summary on behalf of the European geriatric medicine society (EuGMS) and the European diabetes working party for older people (EDWPOP) collaboration. Aging Clin Exp Res. 2023;35(11):2279–2291. PubMed PMC
Leung V., Wroblewski K., Schumm L.P., Huisingh-Scheetz M., Huang E.S. Reexamining the classification of older adults with diabetes by comorbidities and exploring relationships with frailty, disability, and 5-year mortality. J Gerontol A Biol Sci Med Sci. 2021;76(11):2071–2079. PubMed PMC
Munshi M.N., Meneilly G.S., Rodríguez-Mañas L., Close K.L., Conlin P.R., Cukierman-Yaffe T., et al. Diabetes in ageing: pathways for developing the evidence base for clinical guidance. Lancet Diabetes Endocrinol. 2020;8(10):855–867. PubMed PMC
Suikkanen S., Soukkio P., Kautiainen H., Kääriä S., Hupli M.T., Sipilä S., et al. Changes in the severity of frailty among older adults after 12 months of supervised home-based physical exercise: a randomized clinical trial. J Am Med Dir Assoc. 2022;23(10):1717.e9–1717.e15. PubMed
Hayashi C., Toyoda H., Ogata S., Okano T., Mashino S. Long-term participation in community-based group resistance exercises delays the transition from robustness to frailty in older adults: a retrospective cohort study. Environ Health Prev Med. 2021;26(1):105. PubMed PMC
Sadjapong U., Yodkeeree S., Sungkarat S., Siviroj P. Multicomponent exercise program reduces frailty and inflammatory biomarkers and improves physical performance in community-dwelling older adults: a randomized controlled trial. Int J Environ Res Public Health. 2020;17(11) PubMed PMC
Checa-López M., Costa-Grille A., Álvarez-Bustos A., Carnicero-Carreño J.A., Sinclair A., Scuteri A., et al. Effectiveness of a randomized intervention by a geriatric team in frail hospital inpatients in non-geriatric settings: FRAILCLINIC project. J Cachexia Sarcopenia Muscle. 2024;15(1):361–369. PubMed PMC
ClinicalTrials.gov
NCT01654341