AIMS: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after ≥18 months of intervention. METHODS: 298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18-24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). RESULTS: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried's frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3-5.4; p = 0.009 and OR 1.9; 95%CI 1.1-3.1; p = 0.02, respectively). IG participants more frequently improved ≥1 point in SPPB score (OR 1.85; 95%CI 1.09-3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. CONCLUSIONS: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.

1st Faculty of Medicine Charles University Prague Czech Republic

Biomedical Research Center Network for Frailty and Healthy Ageing Institute of Health Carlos 3 Madrid Spain; Department of Geriatrics University Hospital of Getafe Madrid Spain

Centre Hospitalier Universitaire de Bordeaux Bordeaux France

Centre Hospitalier Universitaire de Toulouse Toulouse France

Foundation for Biomedical Research University Hospital of Getafe Madrid Spain

Foundation for Biomedical Research University Hospital of Getafe Madrid Spain; Biomedical Research Center Network for Frailty and Healthy Ageing Institute of Health Carlos 3 Madrid Spain

Foundation for Diabetes Research in Older People and Florence Nightingale Faculty of Nursing Midwifery and Palliative Care King's College London United Kingdom

IdiSNA Navarra Institute for Health Research Public University of Navarra Pamplona Spain

Niche Science and Technology Ltd Richmond United Kingdom

Ulm University Ulm Germany

University of Campania Luigi Vanvitelli Naples Italy

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ClinicalTrials.gov
NCT01654341