Relaxed Selection Limits Lifespan by Increasing Mutation Load
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31257025
DOI
10.1016/j.cell.2019.06.004
PII: S0092-8674(19)30632-4
Knihovny.cz E-resources
- Keywords
- aging, distribution of fitness effects, genome evolution, human genetics, killifishes, life history, lifespan, mitochondrial dysfunction, mutation rate, neutral evolution,
- MeSH
- Killifishes classification genetics MeSH
- Longevity * MeSH
- Gene Frequency MeSH
- Phylogeny MeSH
- Phylogeography MeSH
- Genome, Mitochondrial MeSH
- Mitochondria genetics metabolism MeSH
- Evolution, Molecular MeSH
- Mutation MeSH
- DNA Replication MeSH
- Selection, Genetic * MeSH
- Aging MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
To uncover the selective forces shaping life-history trait evolution across species, we investigate the genomic basis underlying adaptations to seasonal habitat desiccation in African killifishes, identifying the genetic variants associated with positive and relaxed purifying selection in 45 killifish species and 231 wild individuals distributed throughout sub-Saharan Africa. In annual species, genetic drift led to the expansion of nuclear and mitochondrial genomes and caused the accumulation of deleterious genetic variants in key life-history modulating genes such as mtor, insr, ampk, foxo3, and polg. Relaxation of purifying selection is also significantly associated with mitochondrial function and aging in human populations. We find that relaxation of purifying selection prominently shapes genomes and is a prime candidate force molding the evolution of lifespan and the distribution of genetic variants associated with late-onset diseases in different species. VIDEO ABSTRACT.
Department of Biological Science University of Tulsa Tulsa OK 74104 USA
Max Planck Institute for Biology of Ageing 50931 Cologne Germany
The Czech Academy of Sciences Institute of Vertebrate Biology 603 65 Brno Czech Republic
References provided by Crossref.org
Multiple Origins of Sex Chromosomes in Nothobranchius Killifishes
Fast satellite DNA evolution in Nothobranchius annual killifishes
Intra-species differences in population size shape life history and genome evolution
