The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure α-Ag2WO4, irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the first time, that Ag nanoparticles/α-Ag2WO4 composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of α-Ag2WO4 perform the fungicidal activity more efficient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being affected.

CDMF LIEC Chemistry Department of the Federal University of São Carlos P O Box 676 13565 905 São Carlos SP Brazil

Department of Analytical and Physical Chemistry University Jaume 1 Castelló 12071 Spain

Department of Inorganic and Organic Chemistry University Jaume 1 Castelló 12071 Spain

GROC∙UJI Institut de Noves Tecnologies de la Imatge Castelló 12071 Spain

Institute for Nanomaterials Advanced Technologies and Innovation Technical University of Liberec Studentská 1402 2 461 17 Liberec Czech Republic

LIA Laboratory of Applied Immunology Department of Genetics and Evolution Federal University of São Carlos São Carlos Brazil

São Paulo State University Department of Dental Materials and Prosthodontics School of Dentistry at Araraquara Rua Humaitá 1680 14801 903 Araraquara SP Brazil

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