Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry
Language English Country England, Great Britain Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
31311438
PubMed Central
PMC6761645
DOI
10.1161/jaha.118.010881
Knihovny.cz E-resources
- Keywords
- acute coronary syndrome, broken heart syndrome, cancer, malignancy, outcome, takotsubo syndrome,
- MeSH
- Time Factors MeSH
- Middle Aged MeSH
- Humans MeSH
- International Cooperation MeSH
- Neoplasms complications diagnosis mortality MeSH
- Prospective Studies MeSH
- Registries MeSH
- Retrospective Studies MeSH
- Aged MeSH
- Takotsubo Cardiomyopathy complications diagnosis mortality MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
Background Clinical characteristics and outcomes of takotsubo syndrome (TTS) patients with malignancy have not been fully elucidated. This study sought to explore differences in clinical characteristics and to investigate short- and long-term outcomes in TTS patients with or without malignancy. Methods and Results TTS patients were enrolled from the International Takotsubo Registry. The TTS cohort was divided into patients with and without malignancy to investigate differences in clinical characteristics and to assess short- and long-term mortality. A subanalysis was performed comparing long-term mortality between a subset of TTS patients with or without malignancy and acute coronary syndrome (ACS) patients with or without malignancy. Malignancy was observed in 16.6% of 1604 TTS patients. Patients with malignancy were older and more likely to have physical triggers, but less likely to have emotional triggers compared with those without malignancy. Long-term mortality was higher in patients with malignancy (P<0.001), while short-term outcome was comparable (P=0.17). In a subanalysis, long-term mortality was comparable between TTS patients with malignancies and ACS patients with malignancies (P=0.13). Malignancy emerged as an independent predictor of long-term mortality. Conclusions A substantial number of TTS patients show an association with malignancy. History of malignancy might increase the risk for TTS, and therefore, appropriate screening for malignancy should be considered in these patients. Clinical Trial Registration URL: http://www.clinicaltrial.gov. Unique identifier: NCT01947621.
1st Department of Cardiology Medical University of Gdansk Poland
Cardiology 1 Center for Cardiology University Medical Center Mainz Mainz Germany
Cardiology Royal Brompton and Harefield Hospital and Imperial College London United Kingdom
Center for Molecular Cardiology Schlieren Campus University of Zurich Zurich Switzerland
Centro Cardiologico Monzino IRCCS Milan Italy
Charles University Prague and University Hospital Kralovske Vinohrady Prague Czech Republic
Clinic for Cardiology and Pneumology Georg August University Goettingen Goettingen Germany
Department of Cardiology and Angiology Hannover Medical School Hannover Germany
Department of Cardiology and Cardiac Imaging Center University Hospital of Rangueil Toulouse France
Department of Cardiology Charité Campus Rudolf Virchow Berlin Germany
Department of Cardiology Heidelberg University Hospital Heidelberg Germany
Department of Cardiology John Radcliffe Hospital Oxford University Hospitals Oxford United Kingdom
Department of Cardiology Kantonsspital Lucerne Lucerne Switzerland
Department of Cardiology Kantonsspital Winterthur Winterthur Switzerland
Department of Cardiology Kings College Hospital Kings Health Partners London United Kingdom
Department of Cardiology Leiden University Medical Centre Leiden The Netherlands
Department of Cardiology Medical University of Warsaw Poland
Department of Cardiology University Hospital Basel Basel Switzerland
Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany
Department of Internal Medicine 2 Cardiology University of Ulm Medical Center Ulm Germany
Department of Internal Medicine 3 Heart Center University of Cologne Germany
Department of Internal Medicine B University Medicine Greifswald Greifswald Germany
Department of Internal Medicine Cardiology Heart Center Leipzig University Hospital Leipzig Germany
Department of Medicine College of Medicine University of Florida Gainesville FL
Deutsches Herzzentrum München Technische Universität München Munich Germany
Division of Cardiovascular Diseases Mayo Clinic Rochester MN
DZHK partner site Greifswald Greifswald Germany
DZHK partner site Hamburg Kiel Luebeck Hamburg Germany
DZHK partner site Heidelberg Mannheim Mannheim Germany
DZHK partner site Munich Heart Alliance Munich Germany
Fondazione Policlinico Universitario A Gemelli IRCCS Università Cattolica del Sacro Cuore Rome Italy
Heart and Vascular Centre Bad Bevensen Bad Bevensen Germany
Heart Center Turku University Hospital and University of Turku Finland
Heart Department University Hospital San Giovanni di Dio e Ruggi d'Aragona Salerno Italy
Intensive coronary care Unit Moscow City Hospital 1 named after N Pirogov Moscow Russia
Internal Medicine Cardiology Angiology and Pneumology Magdeburg University Magdeburg Germany
Klinik für Innere Medizin 3 Universitätsklinikum des Saarlandes Homburg Saar Germany
Krankenhaus Maria Hilf Medizinische Klinik Stadtlohn Germany
Structural Interventional Cardiology Careggi University Hospital Florence Italy
TJ Health Partners Heart and Vascular Glasgow Kentucky
University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland
University Hospital for Internal Medicine 3 Medical University Innsbruck Innsbruck Austria
University of Southern California Keck School of Medicine Los Angeles CA
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ClinicalTrials.gov
NCT01947621
