SOX11 expression in a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma containing BRAF c.1799_1801delTGA and CTNNB1 c.133T>C mutations
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
PubMed
31327063
DOI
10.1007/s00428-019-02619-4
PII: 10.1007/s00428-019-02619-4
Knihovny.cz E-zdroje
- Klíčová slova
- BRAF, Fibromatosis/fasciitis-like stroma, Mutation, Papillary thyroid carcinoma, SOX11, β-Catenin,
- MeSH
- beta-katenin genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- mutace MeSH
- nádory štítné žlázy genetika metabolismus patologie MeSH
- papilární karcinom štítné žlázy genetika metabolismus patologie MeSH
- protoonkogenní proteiny B-Raf genetika MeSH
- transkripční faktory SOXC biosyntéza MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- beta-katenin MeSH
- BRAF protein, human MeSH Prohlížeč
- CTNNB1 protein, human MeSH Prohlížeč
- protoonkogenní proteiny B-Raf MeSH
- SOX11 protein, human MeSH Prohlížeč
- transkripční faktory SOXC MeSH
We describe a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma (PTC-FLS) that contained the rare BRAF c.1799_1801delTGA (p.V600_K601delinsE) mutation, which has not previously been reported in this tumour, as well as the CTNNB1 c.133T>C (p.S45P) mutation. We also report the novel observation that spindle cells of the mesenchymal component exhibit diffuse nuclear but not cytoplasmic expression of SOX11, whereas the malignant epithelial cells did not. This suggests that immunoreactivity for SOX11 can be an alternative diagnostic tool for evaluating cases of PTC-FLS where the nuclear expression of β-catenin is ambiguous.
Department of Microbiology and Immunology National University of Singapore Singapore Singapore
Department of Pathology Faculty of Medicine in Plzen Charles University Plzen Czech Republic
Department of Pathology National University Hospital Singapore Singapore
Molecular and Genetic Laboratory Biopticka Laboratory Ltd Plzen Czech Republic
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