Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications
Status PubMed-not-MEDLINE Jazyk angličtina Země Spojené státy americké Médium electronic-ecollection
Typ dokumentu přehledy, časopisecké články, práce podpořená grantem
PubMed
26137403
PubMed Central
PMC4485728
DOI
10.1080/2162402x.2015.1008814
PII: 1008814
Knihovny.cz E-zdroje
- Klíčová slova
- CRC, colorectal carcinoma, CTLA4, cytotoxic T lymphocyte-associated protein 4, FDA, Food and Drug Administration, IL, interleukin, KIR, killer cell immunoglobulin-like receptor, MEDI4736, MPDL3280A, NK, natural killer, NSCLC, non-small cell lung carcinoma, PD-1, programmed cell death 1, RCC, renal cell carcinoma, TGFβ1, transforming growth factor β1, TLR, Toll-like receptor, TNFRSF, tumor necrosis factor receptor superfamily, Treg, regulatory T cell, ipilimumab, mAb, monoclonal antibody, nivolumab, pembrolizumab, urelumab,
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Immunomodulatory monoclonal antibodies (mAbs) differ from their tumor-targeting counterparts because they exert therapeutic effects by directly interacting with soluble or (most often) cellular components of the immune system. Besides holding promise for the treatment of autoimmune and inflammatory disorders, immunomodulatory mAbs have recently been shown to constitute a potent therapeutic weapon against neoplastic conditions. One class of immunomodulatory mAbs operates by inhibiting safeguard systems that are frequently harnessed by cancer cells to establish immunological tolerance, the so-called "immune checkpoints." No less than 3 checkpoint-blocking mAbs have been approved worldwide for use in oncological indications, 2 of which during the past 12 months. These molecules not only mediate single-agent clinical activity in patients affected by specific neoplasms, but also significantly boost the efficacy of several anticancer chemo-, radio- or immunotherapies. Here, we summarize recent advances in the development of checkpoint-blocking mAbs, as well as of immunomodulatory mAbs with distinct mechanisms of action.
Gustave Roussy Cancer Campus ; Villejuif France
Gustave Roussy Cancer Campus ; Villejuif France ; INSERM U1015 CICBT507 ; Villejuif France
Sotio a c ; Prague Czech Republic ; Equipe 13 Center de Recherche des Cordeliers ; Paris France
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Lee-Ying RM, Feng X, Smylie M, Monzon JG, Cheng T.. Efficacy of two ipilimumab (IPI) doses (10-vs. 3-mg/kg) in Alberta, Canada, tertiary cancer centers. ASCO Meeting Abstracts 2014; 32:9090
Lheureux S, Butler MO, Fleming GF, Hirte HW, Cristea MC, Ghatage P, Martin LP, Mackay H, Dhani NC, Wilson M, et-al.. A phase 1/2 study of ipilimumab in women with metastatic or recurrent HPV-related cervical carcinoma: a study of the princess margaret and chicago N01 consortia. ASCO Meeting Abstracts 2014; 32:TPS5631
Momtaz P, Gaskell AA, Merghoub T, Viale A, Chapman PB.. Correlation of tumor-derived circulating cell free DNA (cfDNA) measured by digital PCR (DigPCR) with tumor burden measured radiographically in patients (pts) with BRAFV600Emutated melanoma (mel) treated with RAF inhibitor (RAFi) and/or ipilimumab (Ipi). ASCO Meeting Abstracts 2014; 32:9085
Moser J, Pulido J, Dronca RS, Markovic S, Mansfield AS.. The Mayo Clinic experience with the use of kinase inhibitors (KIs), ipilimumab, and bevacizumab in the treatment of metastatic ocular melanoma. ASCO Meeting Abstracts 2014; 32:e20011 PubMed
Neyns B, Wilgenhof S, Corthals J, Heirman C, Thielemans K.. Phase II study of autologous mRNA electroporated dendritic cells (TriMixDC-MEL) in combination with ipilimumab in patients with pretreated advanced melanoma. ASCO Meeting Abstracts 2014; 32:3014 PubMed
Page DB, Diab A, Yuan J, Dong Z, Emerson R, Robins H, Redmond D, Zhao C, Mu Z, Wong P, et-al.. T-cell receptor (TCR) DNA deep sequencing to evaluate clonality of tumor-infiltrating lymphocytes (TILs) in early-stage breast cancer patients (pts) receiving preoperative cryoablation (cryo) and/or ipilimumab (ipi). ASCO Meeting Abstracts 2014; 32:3021
Page DB, Yuan J, Ginsberg A, Dong Z, Wong P, Emerson R, Sung JS, Comstock C, Solomon SB, Sacchini V, et-al.. Tumor and systemic immune responses to preoperative (pre-op) cryoablation (cryo) plus immune therapy with ipilimumab (ipi) in early-stage breast cancer (ESBC). ASCO Meeting Abstracts 2014; 32:64
Patel RK, Ko AH, Onners B, Uram JN, Parkinson R, Sugar E, Lutz E, Zheng L, Laheru DA, Jaffee EM, et-al.. A phase 2, multicenter study of FOLFIRINOX followed by ipilimumab in combination with allogeneic GM-CSF transfected pancreatic tumor vaccine in the treatment of metastatic pancreatic cancer. ASCO Meeting Abstracts 2014; 32:TPS4160
Pavlick AC, Chandra S, Stein C, Madden KM, Kannan R, Escano C, Muren C, Yepes E, Sabado RL, Bhardwaj N, et-al.. Phase II study of low-dose cyclophosphamide and ipilimumab in metastatic melanoma. ASCO Meeting Abstracts 2014; 32:e20025
Piulats Rodriguez JM, Ochoa de Olza M, Codes M, Lopez-Martin JA, Berrocal A, Garcia M, Gurpide A, Homet B, Martin-Algarra S. Phase II study evaluating ipilimumab as a single agent in the first-line treatment of adult patients (Pts) with metastatic uveal melanoma (MUM): the GEM-1 trial. ASCO Meeting Abstracts 2014; 32:9033
Puzanov I, Callahan MK, Linette GP, Patel SP, Luke JJ, Sosman JA, Wolchok JD, Hamid O, Minor DR, Orford KW, et-al.. Phase 1 study of the BRAF inhibitor dabrafenib (D) with or without the MEK inhibitor trametinib (T) in combination with ipilimumab (Ipi) for V600E/K mutation-positive unresectable or metastatic melanoma (MM). ASCO Meeting Abstracts 2014; 32:2511
Puzanov I, Milhem MM, Andtbacka RHI, Minor DR, Hamid O, Li A, Chastain M, Gorski K, Anderson A, Vanderwalde AM, et-al.. Primary analysis of a phase 1b multicenter trial to evaluate safety and efficacy of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB-IV melanoma. ASCO Meeting Abstracts 2014; 32:9029
Riker AI, Rossi GR, Vahanian NN, Link CJ. NLG-0304: a phase 2B study of ipilimumab with or without dorgenmeltucel-L (HyperAcute-Melanoma) immunotherapy for patients with stage IV melanoma. ASCO Meeting Abstracts 2014; 32:TPS9115
Sampson JH, Vlahovic G, Desjardins A, Friedman HS, Baehring JM, Hafler D, Rollin L, Coric V, Perez SN, Reardon DA. Randomized phase IIb study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) alone or in combination with ipilimumab versus bevacizumab in patients (pts) with recurrent glioblastoma (GBM). ASCO Meeting Abstracts 2014; 32:TPS2101
Schaff LR, Lassman AB, Goldlust SA, Cloughesy TF, Singer S, Schwartz GK, Iwamoto FM. Ipilimumab for recurrent glioblastoma (GBM). ASCO Meeting Abstracts 2014; 32:e13026
Schindler K, Harmankaya K, Kuk D, Mangana J, Michielin O, Hoeller C, Dummer R, Pehamberger H, Wolchok JD, Postow MA. Correlation of absolute and relative eosinophil counts with immune-related adverse events in melanoma patients treated with ipilimumab. ASCO Meeting Abstracts 2014; 32:9096
Schmerling R, Herchenhorn D, Rinck JA, Camargo VPD, Camargo J, Serrano SV, Azevedo SJ, Barrios CH, Segalla JGM, Bertoni VD, et-al.. Ipilimumab for stage unresectable III/IV melanoma: Brazilian experience in an expanded access program. ASCO Meeting Abstracts 2014; 32:e20045
Shoukat S, Marcus DM, Rizzo M, Lawson DH, Khosa F, Liu Y, Patel KR, Khan MK. Outcome with stereotactic radiosurgery (SRS) and ipilimumab (Ipi) for malignant melanoma brain metastases (mets). ASCO Meeting Abstracts 2014; 32:9076
Snyder Charen A, Makarov V, Merghoub T, Walsh L, Yuan J, Miller M, Kannan K, Postow MA, Elipenahli C, Liu C, et-al.. The neoantigen landscape underlying clinical response to ipilimumab. ASCO Meeting Abstracts 2014; 32:3003
Sznol M, Kluger HM, Callahan MK, Postow MA, Gordon RA, Segal NH, Rizvi NA, Lesokhin AM, Atkins MB, Kirkwood JM, et-al.. Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in advanced melanoma (MEL). ASCO Meeting Abstracts 2014; 32:LBA9003
Tarhini AA, LaFramboise WA, Petrosko P, Deamont CG, Kirkwood JM.. Clustered genomic variants specific to patients who develop immune-related colitis after ipilimumab for prediction of toxicity. ASCO Meeting Abstracts 2014; 32:9024
Tavares MC, De Barros E, Silva MJ, Rinck JA, Urvanegia ACM, Macedo MP, Pinto C, Bezerra T, Dal Molin GZ, Santos FN, et-al.. Number of sites of metastasis (NSM) and progression-free survival (PFS) in patients (PTS) with melanoma treated with ipilimumab (IPI). ASCO Meeting Abstracts 2014; 32:e20048
Weber JS, Kudchadkar RR, Gibney GT, Yu B, Cheng P, Martinez AJ, Kroeger J, Gallenstein D, Richards A, Welsh E, et-al.. Updated survival, toxicity, and biomarkers of nivolumab with/without peptide vaccine in patients naive to, or progressed on, ipilimumab (IPI). ASCO Meeting Abstracts 2014; 32:3009
Zimmer L, Eigentler TK, Vaubel J-M, Mohr P, Jradi Z, Kiecker F, Utikal J, Berking C, Kämpgen E, Hauschild A, et-al.. Open-label, multicenter, single-arm phase II study (DeCOG-Trial) to further evaluate the efficacy and safety of ipilimumab in patients with cutaneous melanoma and rare subgroups. ASCO Meeting Abstracts 2014; 32:9031
Konstantinou MP, Dutriaux C, Gaudy-Marqueste C, Mortier L, Bedane C, Girard C, Sophie T, Thomas J, Jean-Jacques G, Marie-Aleth R, et-al.. Ipilimumab in melanoma patients with brain metastasis: a retro-spective multicentre evaluation of thirty-eight patients. Acta Derm Venereol 2014; 94:45-9; PMID:; http://dx.doi.org/10.2340/00015555-1654 PubMed DOI
Altomonte M, Di Giacomo A, Queirolo P, Ascierto P, Spagnolo F, Bajetta E, Calabr∫ L, Danielli R, de Rosa F, Maur M, et-al.. Clinical experience with ipilimumab 10-mg/kg in patients with melanoma treated at Italian centres as part of a European expanded access programme. J Exp Clin Cancer Res 2013; 32:82; PMID:; http://dx.doi.org/10.1186/1756-9966-32-82 PubMed DOI PMC
Ascierto PA, Simeone E, Sileni VC, Del Vecchio M, Marchetti P, Cappellini GC, Ridolfi R, de Rosa F, Cognetti F, Ferraresi V, et-al.. Sequential treatment with ipilimumab and BRAF inhibitors in patients with metastatic melanoma: data from the Italian cohort of the ipilimumab expanded access program. Cancer Invest 2014; 32:144-9; PMID:; http://dx.doi.org/10.3109/07357907.2014.885984 PubMed DOI
Jochems C, Tucker JA, Tsang KY, Madan RA, Dahut WL, Liewehr DJ, Steinberg SM, Gulley JL, Schlom J. A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: immune correlates. Cancer Immunol Immunother 2014; 63:407-18; PMID:; http://dx.doi.org/10.1007/s00262-014-1524-0 PubMed DOI PMC
Kelderman S, Heemskerk B, van Tinteren H, van den Brom RR, Hospers GA, van den Eertwegh AJ, Kapiteijn EW, de Groot JW, Soetekouw P, Jansen RL, et-al.. Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma. Cancer Immunol Immunother 2014; 63:449-58; PMID: PubMed PMC
Chiarion Sileni V, Pigozzo J, Ascierto PA, Grimaldi AM, Maio M, Di Guardo L, Marchetti P, de Rosa F, Nuzzo C, Testori A, et-al.. Efficacy and safety of ipilimumab in elderly patients with pretreated advanced melanoma treated at Italian centres through the expanded access programme. J Exp Clin Cancer Res 2014; 33:30; PMID:; http://dx.doi.org/10.1186/1756-9966-33-30 PubMed DOI PMC
Kwon ED, Drake CG, Scher HI, Fizazi K, Bossi A, van den Eertwegh AJ, Krainer M, Houede N, Santos R, Mahammedi H, et-al.. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol 2014; 15:700-12; PMID:; http://dx.doi.org/10.1016/S1470-2045(14)70189-5 PubMed DOI PMC
Lebbe C, Weber JS, Maio M, Neyns B, Harmankaya K, Hamid O, O'Day SJ, Konto C, Cykowski L, McHenry MB, et-al.. Survival follow-up and ipilimumab retreatment of patients with advanced melanoma who received ipilimumab in prior phase II studies. Ann Oncol 2014; 25:2277-84; PMID:; http://dx.doi.org/10.1093/annonc/mdu441 PubMed DOI PMC
Hodi FS, Lee S, McDermott DF, Rao UN, Butterfield LH, Tarhini AA, Leming P, Puzanov I, Shin D, Kirkwood JM. Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial. JAMA 2014; 312:1744-53; PMID:; http://dx.doi.org/10.1001/jama.2014.13943 PubMed DOI PMC
Garcia-Manero G, Martinelli G, Zeidner JF, Avigan D, Anderson KC, Ribrag V, Moskowitz C, Zinzani PL, Wu D, Emancipator K, et-al.. A multicohort trial of the safety and efficacy of the PD-1 inhibitor MK-3475 in patients with hematologic malignancies. ASCO Meeting Abstracts 2014; 32:TPS3116
Garon EB, Leighl NB, Rizvi NA, Blumenschein GR, Balmanoukian AS, Eder JP, Goldman JW, Hui R, Soria J-C, Gangadhar TC, et-al.. Safety and clinical activity of MK-3475 in previously treated patients (pts) with non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 2014; 32:8020
Herbst RS, Gurpide A, Surmont V, Kim D-W, Waqar SN, Herder J, Lee DH, Carcereny E, Reguart N, Wallmark JM, et-al.. A phase II/III randomized trial of two doses of MK-3475 versus docetaxel in previously treated subjects with non-small cell lung cancer. ASCO Meeting Abstracts 2014; 32:TPS8124
Hodi FS, Ribas A, Daud A, Hamid O, Robert C, Kefford R, Hwu W-J, Gangadhar TC, Joshua AM, Hersey P, et-al.. Evaluation of immune-related response criteria (irRC) in patients (pts) with advanced melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475. ASCO Meeting Abstracts 2014; 32:3006
Joseph RW, Elassaiss-Schaap J, Wolchok JD, Joshua AM, Ribas A, Hodi FS, Hamid O, Robert C, Daud A, Hwu W-J, et-al.. Baseline tumor size as an independent prognostic factor for overall survival in patients with metastatic melanoma treated with the anti-PD-1 monoclonal antibody MK-3475. ASCO Meeting Abstracts 2014; 32:3015
Kefford R, Ribas A, Hamid O, Robert C, Daud A, Wolchok JD, Joshua AM, Hodi FS, Gangadhar TC, Hersey P, et-al.. Clinical efficacy and correlation with tumor PD-L1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475. ASCO Meeting Abstracts 2014; 32:3005
Le DT, Azad NS, Laheru D, Browner IS, Wang H, Uram JN, Kemberling H, Zheng L, Iannone R, Friedman E, et-al.. Phase 2 study of programmed death-1 antibody (anti-PD-1, MK-3475) in patients with microsatellite unstable (MSI) tumors. ASCO Meeting Abstracts 2014; 32:TPS3128
McDermott DF, Infante JR, Voss MH, Motzer RJ, Haanen JBAG, Chowdhury S, Perini RF, Iannone R, Hodge R, Figueroa D, et-al.. A phase I/II study to assess the safety and efficacy of pazopanib and MK-3475 in subjects with advanced renal cell carcinoma. ASCO Meeting Abstracts 2014; 32:TPS4604
Nanda R, Plimack ER, Dees EC, Gupta S, Berger R, Elfiky A, Pusztai L, Buisseret L, Geva R, Pai SI, et-al.. A phase Ib multicohort study of MK-3475 in patients with advanced solid tumors. ASCO Meeting Abstracts 2014; 32:TPS3119
Ribas A, Hodi FS, Kefford R, Hamid O, Daud A, Wolchok JD, Hwu W-J, Gangadhar TC, Patnaik A, Joshua AM, et-al.. Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL). ASCO Meeting Abstracts 2014; 32:LBA9000
Rizvi NA, Garon EB, Patnaik A, Gandhi L, Leighl NB, Balmanoukian AS, Goldman JW, Eder JP, Johnson E, Blumenschein GR, et-al.. Safety and clinical activity of MK-3475 as initial therapy in patients with advanced non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 2014; 32:8007
Seiwert TY, Burtness B, Weiss J, Gluck I, Eder JP, Pai SI, Dolled-Filhart M, Emancipator K, Pathiraja K, Gause C, et-al.. A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer. ASCO Meeting Abstracts 2014; 32:6011
Siegel DSD, Moreau P, Avigan D, Anderson KC, Reece DE, San Miguel J, Mateos M-V, Wu D, Emancipator K, Dolled-Filhart M, et-al.. A phase 1 (Ph1) trial of MK-3475 combined with lenalidomide (Len) and low-dose dexamethasone (Dex) in patients (pts) with relapsed/refractory multiple myeloma (RRMM). ASCO Meeting Abstracts 2014; 32:TPS3117
Moskowitz CH, Ribrag V, Michot JM, Martinelli G, Zinzani PL, Gutierrez M, De Maeyer G, Jacob AG, Giallella K, Anderson JW, et-al.. PD-1 blockade with the monoclonal antibody pembrolizumab (MK-3475) in patients with classical Hodgkin lymphoma after brentuximab vedotin failure: preliminary results from a Phase 1b study. ASH Annual Meeting Abstracts 2014; Session 624:Abstract 290
Nanda R, Chow LQ, Dees EC, Berger R, Gupta S, Geva R, Pusztai L, Dolled-Filhart M, Emancipator K, Gonzalez EJ, et-al.. A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer. San Antonio Breast Cancer Symposium Abstracts 2014:S1-09.
Amin A, Plimack ER, Infante JR, Ernstoff MS, Rini BI, McDermott DF, Knox JJ, Pal SK, Voss MH, Sharma P, et-al.. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). ASCO Meeting Abstracts 2014; 32:5010
Antonia SJ, Brahmer JR, Gettinger SN, Chow LQM, Juergens RA, Shepherd FA, Laurie SA, Gerber DE, Goldman JW, Shen Y, et-al.. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 2014; 32:8113
Brahmer JR, Horn L, Gandhi L, Spigel DR, Antonia SJ, Rizvi NA, Leming PD, Topalian SL, Hodi FS, Sznol M, et-al.. Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients (pts) with advanced non-small-cell lung cancer (NSCLC): survival and clinical activity by subgroup analysis. ASCO Meeting Abstracts 2014; 32:8112
Carbone DP, Socinski MA, Chen AC, Bhagavatheeswaran P, Reck M, Paz-Ares L.. A phase III, randomized, open-label trial of nivolumab (anti-PD-1; BMS-936558, ONO-4538) versus investigator's choice chemotherapy (ICC) as first-line therapy for stage IV or recurrent PD-L1+ non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 2014; 32:TPS8128
Choueiri TK, Fishman MN, Escudier BJ, Kim JJ, Kluger HM, Stadler WM, Perez-Gracia JL, McNeel DG, Curti BD, Harrison MR, et-al.. Immunomodulatory activity of nivolumab in previously treated and untreated metastatic renal cell carcinoma (mRCC): biomarker-based results from a randomized clinical trial. ASCO Meeting Abstracts 2014; 32:5012
Gettinger SN, Shepherd FA, Antonia SJ, Brahmer JR, Chow LQM, Juergens RA, Borghaei H, Shen Y, Harbison C, Alaparthy S, et-al.. First-line nivolumab (anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: safety, efficacy, and correlation of outcomes with PD-L1 status. ASCO Meeting Abstracts 2014; 32:8024
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, et-al.. Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer. ASCO Meeting Abstracts 2014; 32:5511
Motzer RJ, Rini BI, McDermott DF, Redman BG, Kuzel T, Harrison MR, Vaishampayan UN, Drabkin HA, George S, Logan TF, et-al.. Nivolumab for metastatic renal cell carcinoma (mRCC): results of a randomized, dose-ranging phase II trial. ASCO Meeting Abstracts 2014; 32:5009 PubMed PMC
Porkka K, Mauro MJ, Lipton JH, Mahon F-X, Strauss LC, Geese WJ, Kroog GS, Mustjoki S. An open-label, phase 1b, dose-escalation study (CA180-373) of dasatinib plus nivolumab, an investigational anti-programmed cell death 1 (PD-1) antibody, in patients (pts) with previously treated chronic myeloid leukemia (CML). ASCO Meeting Abstracts 2014; 32:TPS7119
Rizvi NA, Chow LQM, Borghaei H, Shen Y, Harbison C, Alaparthy S, Chen AC, Gettinger SN. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. ASCO Meeting Abstracts 2014; 32:8022
Segal NH, Hodi FS, Sanborn RE, Gajewski T, Wolchok JD, Urba WJ, Fox BA, Topalian SL, Pardoll DM, Kollia G, et-al.. A phase I dose escalation and cohort expansion study of lirilumab (anti-KIR; BMS-986015) in combination with nivolumab (anti-PD-1; BMS-936558, ONO-4538) in advanced solid tumors. ASCO Meeting Abstracts 2014; 32:TPS3115
Weber JS, Kudchadkar RR, Yu B, Gallenstein D, Horak CE, Inzunza HD, Zhao X, Martinez AJ, Wang W, Gibney G, et-al.. Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma. J Clin Oncol 2013; 31:4311-8; PMID:; http://dx.doi.org/10.1200/JCO.2013.51.4802 PubMed DOI PMC
Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, Brahmer JR, Lawrence DP, Atkins MB, Powderly JD, et-al.. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014; 32:1020-30; PMID:; http://dx.doi.org/10.1200/JCO.2013.53.0105 PubMed DOI PMC
Lesokhin AM, Ansell SM, Armand P, Scott EC, Halwani A, Gutierrez M, Millenson MM, Cohen AD, Schuster SJ, Lebovic D, et-al.. Preliminary results of a Phase I study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies. ASH Annual Meeting Abstracts 2014; Session 624:Abstract 291
Calabro L, Morra A, Fonsatti E, Cutaia O, Fazio C, Danielli R, Giannarelli D, Altomonte M, Di Giacomo AM, Maio M. A phase 2 single-arm study with tremelimumab at an optimized dosing schedule in second-line mesothelioma patients. ASCO Meeting Abstracts 2014; 32:7531
Callahan MK, Ott PA, Odunsi K, Bertolini SV, Pan LS, Venhaus RR, Karakunnel JJ, Hodi FS, Wolchok JD. A phase 1 study to evaluate the safety and tolerability of MEDI4736, an anti-PD-L1 antibody, in combination with tremelimumab in patients with advanced solid tumors. ASCO Meeting Abstracts 2014; 32:TPS3120
Duffy AG, Ulahannan SV, Fioravanti S, Walker M, Figg WD, Compton K, Venkatesan A, Abi-Jaoudeh N, Wood BJ, Greten TF. A pilot study of tremelimumab, a monoclonal antibody against CTLA-4, in combination with either transcatheter arterial chemoembolization (TACE) or radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC). ASCO Meeting Abstracts 2014; 32:e15133
Maio M, Scherpereel A, Di Pietro A, Vasey P, Tsao AS, Calabro L, Fu D, Robbins PB, Ibrahim RA, Kindler HL. Randomized, double-blind, placebo-controlled study of tremelimumab for second- and third-line treatment of unresectable pleural or peritoneal mesothelioma. ASCO Meeting Abstracts 2014; 32:TPS7609
Pinder MC, Rizvi NA, Goldberg SB, Balmanoukian AS, Narwal R, Robbins PB, D'Angelo G, Blake-Haskins A, Karakunnel JJ, Antonia SJ. A phase 1b open-label study to evaluate the safety and tolerability of MEDI4736, an anti-PD-L1 antibody, in combination with tremelimumab in subjects with advanced non-small cell lung cancer. ASCO Meeting Abstracts 2014; 32:e19137
Saenger Y, Magidson J, Liaw B, de Moll E, Harcharik S, Fu Y, Wassmann K, Fisher D, Kirkwood J, Oh WK, et-al.. Blood mRNA expression profiling predicts survival in patients treated with tremelimumab. Clin Cancer Res 2014; 20:3310-8; PMID:; http://dx.doi.org/10.1158/1078-0432.CCR-13-2906 PubMed DOI
Aglietta M, Barone C, Sawyer MB, Moore MJ, Miller WH Jr, Bagala C, Aglietta M, Barone C, Sawyer MB, Moore MJ, et-al.. A phase I dose escalation trial of tremelimumab (CP-675,206) in combination with gemcitabine in chemotherapy-naive patients with metastatic pancreatic cancer. Ann Oncol 2014; 25:1750-5; PMID:; http://dx.doi.org/10.1093/annonc/mdu205 PubMed DOI
Atkins MB, Kudchadkar RR, Sznol M, McDermott DF, Lotem M, Schachter J, Wolchok JD, Urba WJ, Kuzel T, Schuchter LM, et-al.. Phase 2, multicenter, safety and efficacy study of pidilizumab in patients with metastatic melanoma. ASCO Meeting Abstracts 2014; 32:9001
Westin JR, Chu F, Zhang M, Fayad LE, Kwak LW, Fowler N, Romaguera J, Hagemeister F, Fanale M, Samaniego F, et-al.. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol 2014; 15:69-77; PMID:; http://dx.doi.org/10.1016/S1470-2045(13)70551-5 PubMed DOI PMC
Brahmer JR, Rizvi NA, Lutzky J, Khleif S, Blake-Haskins A, Li X, Robbins PB, Vasselli J, Ibrahim RA, Antonia SJ. Clinical activity and biomarkers of MEDI4736, an anti-PD-L1 antibody, in patients with NSCLC. ASCO Meeting Abstracts 2014; 32:8021
Fairman D, Narwal R, Liang M, Robbins PB, Schneider A, Chavez C, Lu H, Pak M, Blake-Haskins A, Vasselli J, et-al.. Pharmacokinetics of MEDI4736, a fully human anti-PDL1 monoclonal antibody, in patients with advanced solid tumors. ASCO Meeting Abstracts 2014; 32:2602
Gordon MS, Lutzky J, Lawrence DP, Orford KW, Blake-Haskins A, Di Pietro A, Robbins PB, Dar MM, Ribas A. Phase 1 study of MEDI4736, an anti-PD-L1 antibody, in combination with dabrafenib and trametinib or trametinib alone in patients with unresectable or metastatic melanoma. ASCO Meeting Abstracts 2014; 32:TPS9108
Lutzky J, Antonia SJ, Blake-Haskins A, Li X, Robbins PB, Shalabi AM, Vasselli J, Ibrahim RA, Khleif S, Segal NH. A phase 1 study of MEDI4736, an anti-PD-L1 antibody, in patients with advanced solid tumors. ASCO Meeting Abstracts 2014; 32:3001
Segal NH, Antonia SJ, Brahmer JR, Maio M, Blake-Haskins A, Li X, Vasselli J, Ibrahim RA, Lutzky J, Khleif S. Preliminary data from a multi-arm expansion study of MEDI4736, an anti-PD-L1 antibody. ASCO Meeting Abstracts 2014; 32:3002
Powles T, Vogelzang NJ, Fine GD, Eder JP, Braiteh FS, Loriot Y, Zambrano CC, Bellmunt J, Burris HA, Melinda Teng S-L, et-al.. Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). ASCO Meeting Abstracts 2014; 32:5011
Rizvi NA, Chow LQM, Dirix LY, Gettinger SN, Gordon MS, Kabbinavar FF, Von Pawel J, Soria J-C, Chappey C, Mokatrin A, et-al.. Clinical trials of MPDL3280A (anti-PDL1) in patients (pts) with non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 2014; 32:TPS8123
Emens LA, Braiteh FS, Cassier P, Delord JP, Eder JP, Shen X, Xiao Y, Wang Y, Hegde PS, Chen DS, et-al.. Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triple-negative breast cancer. San Antonio Breast Cancer Symposium Abstracts 2014:PD1-6.
Heery CR, O'Sullivan Coyne GH, Madan RA, Schlom J, von Heydebreck A, Cuillerot J-M, Sabzevari H, Gulley JL. Phase I open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies. ASCO Meeting Abstracts 2014; 32:3064
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Couzin-Frankel J. Breakthrough of the year 2013. Cancer immunotherapy. Science 2013; 342:1432-3; PMID:; http://dx.doi.org/10.1126/science.342.6165.1432 PubMed DOI
Galluzzi L, Vacchelli E, Bravo-San Pedro JM, Buqué A, Senovilla L, Baracco EE, Bloy N, Castoldi F, Abastado JP, Agostinis P, et-al.. Classification of current anticancer immunotherapies. Oncotarget 2014; 5:12472-508; in press; PMID: PubMed PMC
Peng W, Lizee G, Hwu P.. Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer. Oncoimmunology 2013; 2:e22691; PMID:; http://dx.doi.org/10.4161/onci.22691 PubMed DOI PMC
Reck M, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Lu H, Cuillerot JM, Lynch TJ. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol 2013; 24:75-83; PMID:; http://dx.doi.org/10.1093/annonc/mds213 PubMed DOI
Mavilio D, Lugli E.. Inhibiting the inhibitors: checkpoints blockade in solid tumors. Oncoimmunology 2013; 2:e26535; PMID:; http://dx.doi.org/10.4161/onci.26535 PubMed DOI PMC
Lipson EJ, Sharfman WH, Drake CG, Wollner I, Taube JM, Anders RA, Xu H, Yao S, Pons A, Chen L, et-al.. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res 2013; 19:462-8; PMID:; http://dx.doi.org/10.1158/1078-0432.CCR-12-2625 PubMed DOI PMC
Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS, et-al.. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013; 369:134-44; PMID:; http://dx.doi.org/10.1056/NEJMoa1305133 PubMed DOI PMC
Cooper ZA, Frederick DT, Ahmed Z, Wargo JA.. Combining checkpoint inhibitors and BRAF-targeted agents against metastatic melanoma. Oncoimmunology 2013; 2:e24320; PMID:; http://dx.doi.org/10.4161/onci.24320 PubMed DOI PMC
Vacchelli E, Prada N, Kepp O, Galluzzi L.. Current trends of anticancer immunochemotherapy. Oncoimmunology 2013; 2:e25396; PMID:; http://dx.doi.org/10.4161/onci.25396 PubMed DOI PMC
Hodi FS, Lawrence D, Lezcano C, Wu X, Zhou J, Sasada T, Zeng W, Giobbie-Hurder A, Atkins MB, Ibrahim N, et-al.. Bevacizumab plus ipilimumab in patients with metastatic melanoma. Cancer Immunol Res 2014; 2:632-42; PMID:; http://dx.doi.org/10.1158/2326-6066.CIR-14-0053 PubMed DOI PMC
Vacchelli E, Aranda F, Eggermont A, Galon J, Sautes-Fridman C, Zitvogel L, Kroemer G, Galluzzi L. Trial watch: tumor-targeting monoclonal antibodies in cancer therapy. Oncoimmunology 2014; 3:e27048; PMID:; http://dx.doi.org/10.4161/onci.27048 PubMed DOI PMC
John LB, Kershaw MH, Darcy PK.. Blockade of PD-1 immunosuppression boosts CAR T-cell therapy. Oncoimmunology 2013; 2:e26286; PMID:; http://dx.doi.org/10.4161/onci.26286 PubMed DOI PMC
John LB, Devaud C, Duong CP, Yong CS, Beavis PA, Haynes NM, Chow MT, Smyth MJ, Kershaw MH, Darcy PK. Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin Cancer Res 2013; 19:5636-46; PMID:; http://dx.doi.org/10.1158/1078-0432.CCR-13-0458 PubMed DOI
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Palucka K, Banchereau J.. Dendritic-cell-based therapeutic cancer vaccines. Immunity 2013; 39:38-48; PMID:; http://dx.doi.org/10.1016/j.immuni.2013.07.004 PubMed DOI PMC
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Melcher A, Parato K, Rooney CM, Bell JC.. Thunder and lightning: immunotherapy and oncolytic viruses collide. Mol Ther 2011; 19:1008-16; PMID:; http://dx.doi.org/10.1038/mt.2011.65 PubMed DOI PMC
Zamarin D, Holmgaard RB, Subudhi SK, Park JS, Mansour M, Palese P, Merghoub T, Wolchok JD, Allison JP. Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci Transl Med 2014; 6:226ra32; PMID:; http://dx.doi.org/10.1126/scitranslmed.3008095 PubMed DOI PMC
Nagato T, Celis E.. A novel combinatorial cancer immunotherapy: poly-IC and blockade of the PD-1/PD-L1 pathway. Oncoimmunology 2014; 3:e28440; PMID:; http://dx.doi.org/10.4161/onci.28440 PubMed DOI PMC
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Linch SN, Redmond WL.. Combined OX40 ligation plus CTLA-4 blockade: more than the sum of its parts. Oncoimmunology 2014; 3:e28245; PMID: [http://dx.doi.org/10.4161/onci.28245 PubMed DOI PMC
Barker CA, Postow MA, Khan SA, Beal K, Parhar PK, Yamada Y, Lee NY, Wolchok JD. Concurrent radiotherapy and ipilimumab immunotherapy for patients with melanoma. Cancer Immunol Res 2013; 1:92-8; PMID:; http://dx.doi.org/10.1158/2326-6066.CIR-13-0082 PubMed DOI PMC
Silk AW, Bassetti MF, West BT, Tsien CI, Lao CD.. Ipilimumab and radiation therapy for melanoma brain metastases. Cancer Med 2013; 2:899-906; PMID:; http://dx.doi.org/10.1002/cam4.140 PubMed DOI PMC
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Demaria S, Pilones KA, Formenti SC, Dustin ML.. Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment. Oncoimmunology 2013; 2:e23127; PMID:; http://dx.doi.org/10.4161/onci.23127 PubMed DOI PMC
Semeraro M, Galluzzi L.. Novel insights into the mechanism of action of lenalidomide. Oncoimmunology 2014; 3:e28386; PMID:; http://dx.doi.org/10.4161/onci.28386 PubMed DOI PMC
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Eggermont AM, Robert C.. Melanoma: smart therapeutic strategies in immuno-oncology. Nat Rev Clin Oncol 2014; 11:181-2; PMID:; http://dx.doi.org/10.1038/nrclinonc.2014.36 PubMed DOI
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Baldo BA. Adverse events to monoclonal antibodies used for cancer therapy: focus on hypersensitivity responses. Oncoimmunology 2013; 2:e26333; PMID:; http://dx.doi.org/10.4161/onci.26333 PubMed DOI PMC
Marabelle A, Kohrt H, Sagiv-Barfi I, Ajami B, Axtell RC, Zhou G, Rajapaksa R, Green MR, Torchia J, Brody J, et-al.. Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J Clin Invest 2013; 123:2447-63; PMID:; http://dx.doi.org/10.1172/JCI64859 PubMed DOI PMC
Galluzzi L, Kepp O, Kroemer G.. Immunogenic cell death in radiation therapy. Oncoimmunology 2013; 2:e26536; PMID:; http://dx.doi.org/10.4161/onci.26536 PubMed DOI PMC
Zitvogel L, Galluzzi L, Viaud S, Vetizou M, Daillere R, Merad M, Kroemer G. Cancer and the gut microbiota: an unexpected link. Sci Transl Med 2015; 7:271ps1; in press; PMID: PubMed PMC
Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, Chen L, Pardoll DM, Topalian SL, Anders RA. Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti-PD-1 Therapy. Clin Cancer Res 2014; 20:5064-74; PMID:; http://dx.doi.org/10.1158/1078-0432.CCR-13-3271 PubMed DOI PMC
Kakavand H, Scolyer RA, Thompson JF, Mann GJ.. Identification of new prognostic biomarkers for Stage III metastatic melanoma patients. Oncoimmunology 2013; 2:e25564; PMID: [http://dx.doi.org/10.4161/onci.25564 PubMed DOI PMC
Rodolfo M, Castelli C, Rivoltini L.. Immune response markers in sentinel nodes may predict melanoma progression. Oncoimmunology 2014; 3:e28498; PMID:; http://dx.doi.org/10.4161/onci.28498 PubMed DOI PMC
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Lee AF, Sieling PA, Lee DJ.. Immune correlates of melanoma survival in adoptive cell therapy. Oncoimmunology 2013; 2:e22889; PMID:; http://dx.doi.org/10.4161/onci.22889 PubMed DOI PMC
Kadota K, Nitadori JI, Adusumilli PS.. Prognostic value of the immune microenvironment in lung adenocarcinoma. Oncoimmunology 2013; 2:e24036; PMID:; http://dx.doi.org/10.4161/onci.24036 PubMed DOI PMC
Escors D, Liechtenstein T, Perez-Janices N, Schwarze J, Dufait I, Goyvaerts C, Lanna A, Arce F, Blanco-Luquin I, Kochan G, et-al.. Assessing T-cell responses in anticancer immunotherapy: dendritic cells or myeloid-derived suppressor cells? Oncoimmunology 2013; 2:e26148; PMID:; http://dx.doi.org/10.4161/onci.26148] PubMed DOI PMC
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Malyguine A, Umansky V, Kotlan B, Aptsiauri N, Shurin MR.. Conference overview: cancer immunotherapy and immunomonitoring (CITIM): moving forward. J Immunotoxicol 2012; 9:231-5; PMID:; http://dx.doi.org/10.3109/1547691X.2012.686930 PubMed DOI
Popadic D, Anegon I, Baeten D, Eibel H, Giese T, Marits P, Martinez-Caceres E, Mascart F, Nestle F, Pujol-Borrell R, et-al.. Predictive immunomonitoring – the COST ENTIRE initiative. Clin Immunol 2013; 147:23-6; PMID:; http://dx.doi.org/10.1016/j.clim.2013.01.013 PubMed DOI
Multi-Institutional Evaluation of Pathologists' Assessment Compared to Immunoscore
Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors
Trial watch: Immune checkpoint blockers for cancer therapy
Trial Watch: Immunotherapy plus radiation therapy for oncological indications
Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy
