Influence of salt and acetonitrile on the capillary zone electrophoresis analysis of imatinib in plasma samples
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
18-11776S
Czech Science Foundation - International
PubMed
31429941
DOI
10.1002/elps.201900188
Knihovny.cz E-zdroje
- Klíčová slova
- Acetonitrile, Imatinib, Peak splitting, Simul software, Sodium chloride,
- MeSH
- acetonitrily chemie MeSH
- chlorid sodný chemie MeSH
- elektroforéza kapilární metody MeSH
- imatinib mesylát krev MeSH
- lidé MeSH
- limita detekce MeSH
- lineární modely MeSH
- reprodukovatelnost výsledků MeSH
- software MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- acetonitrile MeSH Prohlížeč
- acetonitrily MeSH
- chlorid sodný MeSH
- imatinib mesylát MeSH
A simple, sensitive, specific, and cost-effective analytical methodology was developed for the analysis of human plasma samples spiked with imatinib by CZE with on-line UV detection in the context of Therapeutic Drug Monitoring. Several analytical conditions such as the ionic strength (I) and the pH of the BGE composed of citric acid and ε-amino caproic acid were studied in regards of the presence of sodium chloride (NaCl) in plasma samples (1% m/v). Computer simulations (Simul software) were used to confirm the experimental results and to understand imatinib electrophoretic behavior in the presence of NaCl. Furthermore, the advantages of adding ACN to the sample containing NaCl to combine efficient protein precipitation and on-line CZE stacking of imatinib were demonstrated. LOD and LOQ values of 48 and 191 ng/mL were obtained from plasma sample supernatant after protein precipitation with ACN, which is much lower than mean imatinib plasma level observed for patients treated by imatinib mesylate (about 1000 ng/mL). Good linearity was obtained in the concentration range 191-5000 ng/mL (R2 > 0.997). RSD of less than 1.68% and 2.60% (n = 6) for migration times and corrected peak areas, respectively, were observed at the LOQ.
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Von Heeren, F., Thormann, W., Electrophoresis 1997, 18, 2415-2426.
Shihabi, Z. K., J. Chromatogr. A 1993, 652, 471-475.
Øtergaard, J., Heegaard, N. H. H., Electrophoresis 2003, 24, 2903-2913.
Leone, A. M., Francis, P. L., Rhodes, P., Moncada, S., Biochem. Biophys. Res. Commun. 1994, 200, 951-957.
Ashri, N. Y., Abdel-Rehim, M., Bioanalysis 2011, 3, 2003-2018.
Lloyd, D. K., J. Chromatogr. A 1996, 735, 29-42.
Clarke, N. J., Tomlinson, A. J., Schomburg, G., Naylor, S., Anal. Chem. 1997, 69, 2786-2792.
Friedberg, M. A., Hinsdale, M., Shihabi, Z. K., J. Chromatogr. A 1997, 781, 35-42.
Carou, M. I. T., Mahía, P. L., Lorenzo, S. M., Fernández, E. F., Rodríguez, D. P., J. Chromatogr. Sci. 2001, 39, 397-401.
Peng, B., Lloyd, P., Schran, H., Clin. Pharmacokinet. 2005, 44, 879-894.
Petain, A., Kattygnarath, D., Azard, J., Chatelut, E., Delbaldo, C., Geoerger, B., Barrois, M., Seronie-Vivien, S., LeCesne, A., Vassal, G., Clin. Cancer Res. 2008, 14, 7102-7109.
Herviou, P., Thivat, E., Richard, D., Roche, L., Dohou, J., Pouget, M., Eschalier, A., Durando, X., Authier, N., Oncol. Lett. 2016, 12, 1223-1232.
Medenica, M., Jancic, B., Ivanovic, D., Malenovic, A., J. Chromatogr. A 2004, 1031, 243-248.
Roth, O., Spreux-Varoquaux, O., Bouchet, S., Rousselot, P., Castaigne, S., Rigaudeau, S., Raggueneau, V., Therond, P., Devillier, P., Molimard, M., Maneglier, B., Clin. Chim. Acta 2010, 411, 140-146.
D'Avolio, A., Simiele, M., De Francia, S., Ariaudo, A., Baietto, L., Cusato, J., Fava, C., Saglio, G., Di Carlo, F., Di Perri, G., J. Pharm. Biomed. Anal. 2012, 59, 109-116.
De Francia, S., D'Avolio, A., De Martino, F., Pirro, E., Baietto, L., Siccardi, M., Simiele, M., Racca, S., Saglio, G., Di Carlo, F., Di Perri, G., J. Chromatogr. B 2009, 877, 1721-1726.
Bakhtiar, R., Lohne, J., Ramos, L., Khemani, L., Hayes, M., Tse, F., J. Chromatogr. B 2002, 768, 325-340.
Xu, Z., Zhang, Y., Yang, L., Qiang, S., Zhang, W., Yu, Z., Hang, T., Wen, A., J. Chromatogr. Sci. 2013, 52, 344-350.
Ajimura, T. O., Borges, K. B., Ferreira, A. F., de Castro, F. A., de Gaitani, C. M., Electrophoresis 2011, 32, 1885-1892.
Rodríguez Flores, J., Berzas, J. J., Castañeda, G., Rodríguez, N., J. Chromatogr. B 2003, 794, 381-388.
Forough, M., Farhadi, K., Eyshi, A., Molaei, R., Khalili, H., Javan Kouzegaran, V., Matin, A. A., J. Chromatogr. A 2017, 1516, 21-34.
Rodríguez, J., Castañeda, G., Muñoz, L., López, S., Anal. Meth. 2014, 6, 3842-3848.
Elhamili, A., Bergquist, J., Electrophoresis 2011, 32, 1778-1785.
Hruška, V., Jaroš, M., Gaš, B., Electrophoresis 2006, 27, 984-991.
Ahmed, O. S., Ladner, Y., Montels, J., Philibert, L., Perrin, C., J. Chromatogr. A 2018, 1579, 121-128.
Malý, M., Dovhunová, M., Dvořák, M., Gerlero, G.S., Kler, P. A., Hruška, V., Dubský, P., Electrophoresis 2019, 40, 683-692.
Revilla, A. L., Havel, J., Jandik, P., J. Chromatogr. A 1996, 745, 225-232.
Ermakov, S. V., Zhukov, M. Y., Capelll, L., Righetti, P. G., Anal. Chem. 1994, 66, 4034-4042.
Malá, Z., Gebauer, P., Electrophoresis 2006, 27, 4601-4609.
Malá, Z., Gebauer, P., Boček, P., Electrophoresis 2009, 30, 866-874.
Gebauer, P., Boček, P., Electrophoresis 2005, 26, 453-462.
Polson, C., Sarkar, P., Incledon, B., Raguvaran, V., Grant, R., J. Chromatogr. B 2003, 785, 263-275.
Tůma, P., Bursová, M., Sommerová, B., Horsley, R., Čabala, R., Hložek, T., J. Pharm. Biomed. Anal. 2018, 160, 368-373.
Lankheet, N. A. G., Knapen, L. M., Schellens, J. H. M., Beijnen, J. H., Steeghs, N., Huitema, A. D. R., Ther. Drug Monit. 2014, 36, 326-334.
