BACKGROUND: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. MAIN BODY: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. CONCLUSION: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.

1st Department of Family Medicine Medical University of Lodz Łódź Poland

Academic Centre of Primary Care University of Aberdeen Aberdeen Scotland UK

Academic Medical Center Univ of Amsterdam Amsterdam The Netherlands

Allergy and Asthma Associates of Southern California Mission Viejo CA USA

Allergy and Asthma Center Westend Berlin Germany

Allergy and Asthma Medical Group and Research Center San Diego CA USA

Allergy and Asthma Unit Hospital San Bernardo Salta Salta Argentina

Allergy and Clinical Immunology Department Centro Médico Docente la Trinidad and Clínica El Avila Caracas Venezuela

Allergy and Immunology Laboratory Metropolitan University Simon Bolivar University Barranquilla Colombia

Allergy and Respiratory Research Group The University of Edinburgh Edinburgh UK

Allergy Center CUF Descobertas Hospital Lisbon Portugal

Allergy Department 2nd Pediatric Clinic Athens General Children's Hospital P and A Kyriakou University of Athens Athens Greece

Allergy Department Pasteur Institute Paris France

Allergy Section Department of Internal Medicine Hospital Vall d'Hebron and ARADyAL Research Network Barcelona Spain

Allergy Service University Hospital of Federal University of Santa Catarina Florianópolis Brazil

Allergy Unit CUF Porto Hospital and Institute Porto Portugal

Allergy Unit Department of Dermatology University Hospital of Zurich Zurich Switzerland

Allergy Unit Presidio Columbus Catholic University of Sacred Heart Rome Italy

AQuAS Barcelna Spain

Argentine Association of Allergy and Clinical Immunology Buenos Aires Argentina

ASA Advanced Solutions Accelerator Clapiers France

Association Asthme et Allergie Paris France

Association of Finnish Pharmacists Helsinki Finland

Asthma UK Mansell Street London UK

Bull DSAS Echirolles France

Cáritas Diocesana de Coimbra Coimbra Portugal

Center for Allergy and Immunology Santa Fe Argentina

Center for Research in Health Technologies and Information Systems CINTESIS Universidade do Porto Porto Portugal

Center for Rhinology and Allergology Wiesbaden Germany

Center of Allergy and Immunology Georgian Association of Allergology and Clinical Immunology Tbilisi Georgia

Center of Allergy Immunology and Respiratory Diseases Santa Fe Argentina

Center of Excellence in Asthma and Allergy Médica Sur Clinical Foundation and Hospital México City Mexico

Centich Centre d'Expertise National des Technologies de l'Information et de la Communication pour l'Autonomie Gérontopôle Autonomie Longévité des Pays de la Loire Conseil Régional des Pays de la Loire Centre d'Expertise Partenariat Européen d'Innovation pour un Vieillissement Actif et en Bonne Santé Nantes France

Centre for Clinical Research Sörmland Uppsala University Eskilstuna Sweden

Centre for Empowering Patients and Communities Faulkland Somerset UK

Centre for Respiratory Medicine and Allergy Institute of Inflammation and Repair University of Manchester and University Hospital of South Manchester Manchester UK

Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle Ouagadougou Burkina Faso

Chachava Clinic David Tvildiani Medical University AIETI Medical School Grigol Robakidze University Tbilisi Georgia

Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt Uniersität zu Berlin Berlin Germany

Children's Hospital Srebrnjak Zagreb Croatia

CHU Dijon France

CIBER Epidemiología y Salud Pública Barcelona Spain

CINTESIS Center for Research in Health Technology and Information Systems Faculdade de Medicina da Universidade do Porto Porto Portugal

CIRFF Federico 2 University Naples Italy

Clinic for Pulmonary Diseases Clinical Center of Serbia Faculty of Medicine University of Belgrade Serbian Association for Asthma and COPD Belgrade Serbia

Clinic of Children's Diseases Faculty of Medicine Vilnius University Vilnius Lithuania

Clinic of Infectious Chest Diseases Dermatology and Allergology Vilnius University Vilnius Lithuania

Clinical and Experimental Respiratory Immunoallergy IDIBAPS CIBERES University of Barcelona Barcelona Spain

Clinical Medicine Laval's University Quebec City Canada

Clinical Reserch Center for Allergy and Rheumatology Sagamihara National Hospital Sagamihara Japan

CNR Institute of Biomedicine and Molecular Immunology A Monroy Palermo Italy

Coimbra Institute for Clinical and Biomedical Research Faculty of Medicine University of Coimbra Coimbra Portugal

Conseil Général de l'Economie Ministère de l'Economie de l'Industrie et du Numérique Paris France

Consortium of Pharmacies and Services COSAFER Salerno Italy

CRI Clinical Research International Ltd Hamburg Germany

Croatian Pulmonary Society Zagreb Croatia

Cyprus International Institute for Environmental and Public Health in Association with Harvard School of Public Health Cyprus University of Technology Limassol Cyprus

Danish Commitee for Health Education Copenhagen East Denmark

Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon South Korea

Department of Allergy and Immunology Hospital Quirónsalud Bizkaia Erandio Spain

Department of Allergy Immunology and Respiratory Medicine Alfred Hospital and Central Clinical School Monash University Melbourne VIC Australia

Department of Biochemistry and Clinical Chemistry Faculty of Pharmacy with the Division of Laboratory Medicine Warsaw Medical University Warsaw Poland

Department of Chest Medicine Centre Hospitalier Universitaire UCL Namur Université Catholique de Louvain Yvoir Belgium

Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton ON Canada

Department of Clinical Immunology Wrocław Medical University Wrocław Poland

Department of Clinical Pharmacy of Lithuanian University of Health Kaunas Lithuania

Department of Clinical Science and Education Södersjukhuset Karolinska Institutet Stockholm Sweden

Department of Dermatology and Allergy Centre Odense University Hospital Odense Research Center for Anaphylaxis Odense Denmark

Department of Dermatology and Allergy Member of GA2LEN Comprehensive Allergy Centre Berlin Institute of Health Berlin Germany

Department of ENT Medical University of Graz Graz Austria

Department of Geriatrics Montpellier University hospital Montpellier France

Department of Health Social Services and Public Safety Belfast Northern Ireland UK

Department of Immunology and Allergology Faculty of Medicine and Faculty Hospital in Pilsen Charles University Prague Pilsen Czech Republic

Department of Immunology and Allergy Healthy Ageing Research Center Medical University of Lodz Łódź Poland

Department of Infection Immunity and Inflammation University of Leicester Leicester UK

Department of Internal Medicine Medical University of Graz Graz Austria

Department of Lung Diseases and Clinical Immunology University of Turku and Terveystalo Allergy Clinic Turku Finland

Department of Medical Sciences Allergy and Clinical Immunology Unit University of Torino and Mauriziano Hospital Turin Italy

Department of Medicine and Surgery University of Salerno Baronissi Italy

Department of Medicine Bon Secours Hospital Glasnevin Dublin Ireland

Department of Medicine Clinical Immunology and Allergy McMaster University Hamilton ON Canada

Department of Medicine Surgery and Dentistry Scuola Medica Salernitana University of Salerno Salerno Italy

Department of Medicine University of Cape Town Cape Town South Africa

Department of Nephrology and Endocrinology Karolinska University Hospital Stockholm Sweden

Department of Obstetrics and Gynaecology Erasmus MC University Medical Center Rotterdam The Netherlands

Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital and Beijing Institute of Otolaryngology Beijing China

Department of Otolaryngology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

Department of Otorhinolaryngology Amsterdam University Medical Centres AMC Amsterdam The Netherlands

Department of Otorhinolaryngology Head and Neck Surgery Section of Rhinology and Allergy University Hospital Marburg Philipps Universität Marburg Marburg Germany

Department of Otorhinolaryngology University of Crete School of Medicine Heraklion Greece

Department of Paediatrics and Child Health Red Cross Children's Hospital Cape Town South Africa

Department of Paediatrics and Child Health University College Cork Cork Ireland

Department of Paediatrics Oslo University Hospital Oslo Norway

Department of Pediatric Pneumology and Immunology AG Molecular Allergology and Immunomodulation Charité Medical University Berlin Germany

Department of Pediatrics Hospital Archbishop Makarios 3 Nicosia Cyprus

Department of Pharmacy University of Naples Federico 2 Naples Italy

Department of Physiology CHRU University Montpellier Vice President for Research PhyMedExp INSERM U1046 CNRS UMR 9214 Montpellier France

Department of Prevention of Environmental Hazards and Allergology Medical University of Warsaw Warsaw Poland

Department of Public Health and Primary Care Leiden University Medical Center Leiden The Netherlands

Department of Pulmonary Diseases Celal Bayar University Faculty of Medicine Manisa Turkey

Department of Pulmonary Diseases Istanbul University Cerrahpasa Cerrahpasa Faculty of Medicine Istambul Turkey

Department of Pulmonary Medicine CHU Sart Tilman and GIGA I3 Research Group Liege Belgium

Department of Pulmonary Medicine Rashid Hospital Dubai UAE

Department of Respiratory Medicine and Allergology University Hospital Lund Sweden

Department of Respiratory Medicine Hvidovre Hospital and University of Copenhagen Copenhagen Denmark

Department of Respiratory Medicine University Hospital Olomouc Olomouc Czech Republic

Departments of Internal Medicine and Pediatrics University of Tennessee College of Medicine Germantown TN USA

Dept of Comparative Medicine Messerli Research Institute of the University of Veterinary Medicine and Medical University Vienna Austria

Dept of Otolaryngology Head and Neck Surgery University of Mainz Mainz Germany

Dept of Otolaryngology Nippon Medical School Tokyo Japan

Dept of Otorhinolaryngology Chiba University Hospital Chiba Japan

Dept of Otorhinolaryngology HNO Klinik Universitätsklinikum Düsseldorf Düsseldorf Germany

Dept of Otorhinolaryngology Univ Hospitals Leuven Louvain Belgium

Dept of Respiratory Medicine Ghent University Hospital Ghent Belgium

Dept of Respiratory Medicine National Institute of Diseases of the Chest and Hospital Dhaka Bangladesh

DG for Health and Social Care Scottish Government Edinburgh UK

Die Hautambulanz and Rothhaar Study Center Berlin Germany

Division for Health Innovation Campania Region and Federico 2 University Hospital Naples Naples Italy

Division of Allergy Asthma and Clinical Immunology Emek Medical Center Afula Israel

Division of Allergy Clinical Immunology and Rheumatology Department of Pediatrics Federal University of São Paulo São Paulo Brazil

Division of Allergy Department of Pediatric Medicine The Bambino Gesù Children's Research Hospital Holy See Rome Italy

Division of Allergy Immunology and Transplantation National Institute of Allergy and Infectious Diseases NIH Bethesda USA

Division of Allergy Immunology University of South Florida Tampa FL USA

Division of Clinical Immunology and Allergy Laboratory of Behavioral Immunology Research The University of Mississippi Medical Center Jackson MS USA

Division of Immunopathology Department of Pathophysiology and Allergy Research Center for Pathophysiology Infectiology and Immunology Medical University of Vienna Vienna Austria

Division of Infection Immunity and Respiratory Medicine Royal Manchester Children's Hospital University of Manchester Manchester UK

Division of Internal Medicine Asthma and Allergy Barlicki University Hospital Medical University of Lodz Łódź Poland

Division of Respiratory and Allergic Diseases Department of Respiratory Diseases High Specialty Hospital A Cardarelli Naples Italy

EA 2991 Euromov University Montpellier Montpellier France

Ecole des Mines Alès France

EFA European Federation of Allergy and Airways Diseases Patients' Associations Brussels Belgium

EIP AHA Reference Site Coimbra Portugal

EIT Health France Paris France

ENT Department University Hospital of Kinshasa Kinshasa Congo

Epidemiology of Allergic and Respiratory Diseases Department Institute Pierre Louis of Epidemiology and Public Health INSERM and Sorbonne Université Medical School Saint Antoine Paris France

ERS President 2017 2018 Athens Chest Hospital 7th Resp Med Dept and Asthma Center Athens Greece

Eshelman School of Pharmacy University of North Carolina Chapel Hill NC USA

EUREGHA European Regional and Local Health Association Brussels Belgium

European Forum for Research and Education in Allergy and Airway Diseases Brussels Belgium

European Health Futures Forum Dromahair UK

Faculty of Health Sciences and CICS UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal

Faculty of Medicine and Surgery University of Medicine La Valette Malta

Faculty of Medicine Institute of Clinical Medicine University of Oslo Oslo Norway

Faculty of Medicine Transylvania University Brasov Romania

Faculty of Medicine Vilnius University Vilnius Lithuania

Farmacias Holon Lisbon Portugal

Farmacie Dei Golfi Group Massa Lubrense Italy

FILHA Finnish Lung Association Helsinki Finland

Food Allergy Referral Centre Veneto Region Department of Women and Child Health Padua General University Hospital Padua Italy

GARD Chairman Geneva Switzerland

Global Allergy and Asthma Platform GAAPP Vienna Austria

Global Alliance against Chronic Respiratory Diseases Joensuu Finland

Hallym University College of Medicine Hallym University Sacred Heart Hospital Anyang Gyeonggi do South Korea

Health Planning Unit Department of Social Medicine Faculty of Medicine University of Crete Crete Greece

Hospital Civil de Guadalajara Dr Juan 1 Menchaca Guadalarara Mexico

Hospital de Clinicas University of Parana Paraná Brazil

Hospital of the Hospitaller Brothers in Buda Budapest Hungary

IMIM Barcelona Spain

Immunology and Allergy Division Clinical Hospital University of Chile Santiago Chile

Imunoalergologia Centro Hospitalar Universitário de Coimbra and Faculty of Medicine University of Coimbra Coimbra Portugal

INSERM U 1168 VIMA Ageing and Chronic Diseases Epidemiological and Public Health Approaches Villejuif Université Versailles St Quentin en Yvelines UMR S 1168 Montigny Le Bretonneux France

INSERM U1042 and CHU de Grenoble Grenoble France

Institute for Clinical Epidemiology and Biometry University of Wuerzburg Würzburg Germany

Institute of Clinical Medicine and Institute of Health Sciences Vilnius University Faculty of Medicine Vilnius Lithuania

Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden

Institute of Health Policy and Management iBMG Erasmus University Rotterdam The Netherlands

Institute of Lung Health Respiratory Biomedical Unit University Hospitals of Leicester NHS Trust Leicestershire UK

Institute of Medical Statistics and Computational Biology Medical Faculty University of Cologne Cologne Germany

Institute of Social Medicine Epidemiology and Health Economics Charité Universitätsmedizin Berlin Berlin Germany

International Primary Care Respiratory Group IPCRG Aberdeen Scotland UK

iQ4U Consultants Ltd London UK

IRCCS Oasi Maria SS Troina Italy

ISGlobAL Centre for Research in Environmental Epidemiology Barcelona Spain

Johns Hopkins School of Medicine Baltimore MD USA

Kronikgune International Centre of Excellence in Chronicity Research Barakaldo Barakaldo Bizkaia Spain

KYomed INNOV Montpellier France

Kyrgyzstan National Centre of Cardiology and Internal Medicine Euro Asian Respiratory Society Bishkek Kyrgyzstan

La Rochelle France

Laboratoire HP2 Université Grenoble Alpes Grenoble France

Laboratory of Immunopathology Department of Clinical Immunology and Allergy Sechenov 1st Moscow State Medical University Moscow Russia

Life and Health Sciences Research Institute School of Medicine University of Minho Braga Portugal

MACVIA France Fondation Partenariale FMC VIA LR CHU 34295 Montpellier Cedex 5 France

Maladies Infectieuses et immunitaires CHUL Quebec City QC Canada

Mattone Internazionale Program Veneto Region Italy

Medical Consulting Czarlewski Levallois France

Medical Faculty ENT Department Eskisehir Osmangazi University Eskisehir Turkey

Medical Faculty Skopje University Clinic of Pulmonology and Allergy Skopje Republic of Macedonia

Medicine Department Hôpital de la Malbaie Quebec city QC Canada

Medida Lda Porto Portugal

MedScript Ltd Paraparomu New Zealand

Mexico City Mexico

Montevideo Uruguay

MRC Unit on Child and Adolescent Health University of Cape Town Cape Town South Africa

Municipality Pharmacy Sarno Italy

National Center for Disease Control and Public Health of Georgia Tbilisi Georgia

National Center for Research in Chronic Respiratory Diseases Tishreen University School of Medicine Latakia Syria

National Center of Expertise in Cognitive Stimulation Broca Hospital Paris France

National Heart and Lung Institute Royal Brompton Hospital and Imperial College London UK

National Hospital Organization Tokyo National Hospital Tokyo Japan

National Institute for Health and Welfare Helsinki Finland

National Institute of Pneumology M Nasta Bucharest Romania

National Research Center Institute of Immunology Federal Medicobiological Agency Laboratory of Molecular Immunology Moscow Russian Federation

Nova Southeastern University Fort Lauderdale FL USA

NRC Institute of Immunology FMBA of Russia Moscow Russia

OPC Cambridge UK

Pediatric Allergy and Asthma Unit Hacettepe University School of Medicine Ankara Turkey

Pediatric Allergy and Immunology Unit Children's hospital Ain Shams University Cairo Egypt

Personalized Medicine Clinic Asthma and Allergy Humanitas University Humanitas Research Hospital Rozzano Milan Italy

PNDR Portuguese National Programme for Respiratory Diseases Faculdade de Medicina de Lisboa Lisbon Portugal

Pneumologie et Soins Intensifs Respiratoires Hôpitaux Universitaires Paris Centre Hôpital Cochin Paris France

Pneumology and Allergy Department CIBERES and Clinical and Experimental Respiratory Immunoallergy IDIBAPS University of Barcelona Barcelona Spain

ProAR Nucleo de Excelencia em Asma Federal University of Bahia Bahia Brazil

PT Government Associate Laboratory ICVS 3B's Braga Guimarães Portugal

Pulmonary Division Heart Institute Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil

Pulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology Pisa Italy

Pulmonary Unit Department of Medical Specialties Arcispedale SMaria Nuova IRCCS AUSL di Reggio Emilia Reggio Emilia Italy

Quebec Heart and Lung Institute Laval University Quebec City QC Canada

Regional Ministry of Health of Andalusia Seville Spain

Regione Piemonte Turin Italy

Reims France

Research in Real Life Cambridge UK

Rhinology Unit and Smell Clinic ENT Department Hospital Clínic Barcelona Spain

RNSA Brussieu France

Sach's Children and Youth Hospital Södersjukhuset Stockholm Sweden

School of Medicine University J J Strossmayer Osijek Croatia

Scientific Centre of Children's Health under the Russian Academy of Medical Sciences Moscow Russia

Scottish Centre for Respiratory Research Cardiovascular and Diabetes Medicine Medical Research Institute Ninewells Hospital University of Dundee Dundee UK

Section of Allergy and Immunology Saint Louis University School of Medicine Saint Louis MO USA

Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina

Sidkkids Hospitala and Institute of Health Policy Management and Evaluation Toronto Canada

Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland

SLaai Sociedad Latinoamericana de Allergia Asma e Immunologia Barranquilla Colombia

Sleep Unit Department of Neurology Hôpital Gui de Chauliac Montpellier Inserm U1061 Montpellier France

Sociedad Paraguaya de Alergia Asma e Inmunologia Asunción Paraguay

SOS Allergology and Clinical Immunology USL Toscana Centro Prato Italy

State Key Laboratory of Respiratory Diseases Guangzhou Institute of Respiratory Disease The 1st Affiliated Hospital of Guangzhou Medical University Guangzhou China

Swiss Institute of Allergy and Asthma Research University of Zurich Davos Switzerland

Sydney Local Health District Glebe NSW Australia

Syrian Private University Damascus Syria

Termofischer Scientific Uppsala Sweden

The Allergy and Asthma Institute Islamabad Pakistan

The Usher Institute of Population Health Sciences and Informatics The University of Edinburgh Edinburgh UK

Tobacco Control Research Centre Iranian Anti Tobacco Association Tehran Iran

UCIBIO REQUINTE Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto Porto Portugal

Ukrainian Medical Stomatological Academy Poltava Ukraine

Unit of Geriatric Immunoallergology University of Bari Medical School Bari Italy

Universidad Autónoma de Nuevo León San Nicolás de los Garza Mexico

Universidad Católica de Córdoba Córdoba Argentina

Universitat Pompeu Fabra Barcelona Spain

Universitätsmedizin der Johannes Gutenberg Universität Mainz Mainz Germany

Université Paris Sud; Service de Pneumologie Hôpital Bicêtre Inserm UMR_S999 Le Kremlin Bicêtre France

University Clinic of Respiratory and Allergic Diseases Golnik Slovenia

University Hospital 'Sv Ivan Rilski' Sofia Bulgaria

University of Medicine and Pharmacy Hochiminh City Vietnam

UOC Pneumologia Istituto di Medicina Interna F Policlinico Gemelli IRCCS Università Cattolica del Sacro Cuore Rome Italy

Upper Airways Research Laboratory ENT Dept Ghent University Hospital Ghent Belgium

UPRES EA220 Pôle des Maladies des Voies Respiratoires Hôpital Foch Université Paris Saclay Suresnes France

WHO GARD Planning Group Salvador Brazil

Woolcock Emphysema Centre Sydney Australia

Woolcock Institute of Medical Research University of Sydney Sydney Australia

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Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-air® approach

Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold: An ARIA-EAACI-GA2 LEN consensus