MASK-air® , a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air® results should lead to change management in rhinitis and asthma.

Agency of Health ASL Salerno Italy

ALL MED Medical Research Institute Wroclaw Poland

Allergist Reims France

Allergy and Clinical Immunology Unit Centro Hospitalar e Universitário de Coimbra Coimbra Portugal

Allergy Center CUF Descobertas Hospital Lisbon Portugal

Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece

Allergy Division Chest Disease Department University Hospital of Strasbourg Strasbourg France

Allergy Section Department of Internal Medicine Hospital Vall d'Hebron Barcelona Spain

Allergy Unit D Kalogeromitros 2nd Department of Dermatology and Venereology National and Kapodistrian University of Athens Attikon University Hospital Athens Greece

ARADyAL Research Network Barcelona Spain

ASA Advanced Solutions Accelerator Jacou France

Asthma Reference Center School of Medicine of Santa Casa de Misericórdia of Vitória Vitoria Espirito Santo Brazil

Berlin Institute of Health Berlin Germany

Center for Rhinology and Allergology Wiesbaden Germany

Center of Allergy Immunology and Respiratory Diseases Santa Fe Argentina

Center of Excellence in Asthma and Allergy Médica Sur Clinical Foundation and Hospital México City Mexico

Centre Hospitalier Valenciennes Valenciennes France

Cerrahpasa Faculty of Medicine Department of Pulmonary Diseases Istanbul University Cerrahpasa Istanbul Turkey

Chiba Rosai Hospital Chiba Japan

Chiba University Hospital Chiba Japan

CIBER Epidemiología y Salud Pública Barcelona Spain

CINTESIS Health Research Network Faculty of Medicine University of Porto Porto Portugal

CIRFF Department of Pharmacy University of Naples Federico 2 Naples Italy

Clinical and Experimental Respiratory Immunoallergy IDIBAPS CIBERES University of Barcelona Barcelona Spain

Clinique des Bronches Allergie et Sommeil Hôpital Nord Marseille France

Conseil Général de l'Economie Ministère de l'Economie de l'Industrie et du Numérique Paris France

CRI Clinical Research International Ltd Hamburg Germany

Department of Allergology Medical University of Gdańsk Gdansk Poland

Department of Allergy and Immunology Hospital Quironsalud Bizkaia Bilbao Spain

Department of Allergy Hospital La Paz Institute for Health Research Madrid Spain

Department of Allergy Immunology and Respiratory Medicine Alfred Hospital and Central Clinical School Monash University Melbourne Victoria Australia

Department of Biomedical Sciences Humanitas University Pieve Emanuele Milan Italy

Department of Chest Medicine Centre Hospitalier Universitaire UCL Namur Namur Belgique

Department of Clinical and Surgical Sciences Fondazione Policlinico Universitario A Gemelli IRCCS Rome Italy

Department of Clinical Immunology Wrocław Medical University Wrocław Poland

Department of Clinical Science and Education Södersjukhuset Karolinska Institutet Stockholm Sweden

Department of Dermatology and Allergy Centre Odense University Hospital Odense Finland

Department of General ORL H and NS Medical University of Graz ENT University Hospital Graz Graz Steiermark Austria

Department of Geriatrics Montpellier University Hospital MUSE Montpellier France

Department of Health Research Methods Evidence and Impact and Department of Medicine McMaster University Hamilton ON Canada

Department of Immunoallergology Cova da Beira University Hospital Centre Covilhã Portugal

Department of Internal Medicine University of Genoa Genova Italy

Department of Lung Diseases and Clinical Immunology University of Turku Turku Finland

Department of Medical Sciences Allergy and Clinical Immunology Unit University of Torino Torino Italy

Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology University Hospital Duilio Casula University of Cagliari Cagliari Italy

Department of Medicine Clinical Immunology and Allergy McMaster University Hamilton Ontario Canada

Department of Medicine Surgery and Dentistry Scuola Medica Salernitana University of Salerno Salerno Italy

Department of Otolaryngology Head and Neck Surgery Eye and Ear University Hospital Beirut Lebanon

Department of Otolaryngology Head and Neck Surgery Universitätsmedizin Mainz Mainz Germany

Department of Otorhinolaryngology Amsterdam University Medical Centres AMC Amsterdam the Netherlands

Department of Otorhinolaryngology Amsterdam University Medical Centres location AMC Amsterdam the Netherlands

Department of Otorhinolaryngology Charité Universitätsmedizin Berlin Berlin Germany

Department of Otorhinolaryngology Head and Neck Surgery Dar Al Shifa Hospital Salmiya Kuwait

Department of Otorhinolaryngology Head and Neck Surgery Semmelweis University Budapest Hungary

Department of Otorhinolaryngology Head and Neck Surgery University Hospital of Crete Heraklion Crete Greece

Department of Pediatric Respiratory Diseases and Allergology Medical University of Warsaw Warsaw Poland

Department of Pneumology Medical University of Gdańsk Gdańsk Poland

Department of Prevention of Environmental Hazards Allergology and Immunology Medical University of Warsaw Warsaw Poland

Department of Pulmonary Diseases Celal Bayar University Faculty of Medicine Manisa Turkey

Department of Pulmonary Medicine CHU Liege Liège Belgium

Department of Respiratory Medicine and Tuberculosis University Hospital Brno Czech Republic

Division of Allergy and Clinical Immunology Department of Medicine Santa Maria della Speranza Hospital Battipaglia Salerno Italy

Division of Internal Medicine Asthma and Allergy Barlicki University Hospital Medical University of Lodz Lodz Poland

Ecole des Mines Alès France

Ecole Polytechnique Palaiseau IRBA Bretigny France

Faculty of Health Sciences and CICS UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal

Faculty of Medicine Department of Pathology Institute of Biomedical Sciences Vilnius University Vilnius Lithuania

Faculty of Medicine Institute of Clinical Medicine Clinic of Chest Diseases and Allergology Vilnius University Vilnius Lithuania

Faculty of Medicine University of Ljubljana Ljubljana Slovenia

Federation of Translational Medicine University of Strasbourg Strasbourg France

Fihla Finnish Lung Association Helsinki Finland

Finnish Meteorological Institute Helsinki Finland

Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Allergology and Immunology Berlin Germany

Fundaçao ProAR Federal University of Bahia and GARD WHO Planning Group Salvador Bahia Brazil

Fundacion Jimenez Diaz CIBERES Faculty of Medicine Autonoma University of Madrid Madrid Spain

GIGA I3 Research Group University of Liege Liège Belgium

GRADeS Occitanie Toulouse France

Health Planning Unit Faculty of Medicine Department of Social Medicine University of Crete Crete Greece

ICBR Coimbra Institute for Clinical and Biomedical Research CIBB Faculty of Medicine University of Coimbra Coimbra Portugal

IMIM Barcelona Spain

Imunoalergologia Centro Hospitalar Universitário de Coimbra Faculty of Medicine University of Coimbra Coimbra Portugal

Inserm Equipe d'Epidémiologie Respiratoire Intégrative CESP Villejuif France

INSERM U1042 Villejuif France

Institute for Clinical Epidemiology and Biometry University of Wuerzburg Wuerzburg Germany

Institute of Allergology Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin Berlin Germany

Institute of Clinical Medicine and Institute of Health Sciences Vilnius Lithuania

Institute of Immunology Faculty of Medicine University of Coimbra Coimbra Portugal

Institute of Social Medicine Epidemiology and Health Economics Charité Universitätsmedizin Berlin Berlin Germany

International Primary Care Respiratory Group IPCRG Aberdeen Scotland

IRCCS Ospedale Policlinico San Martino Genova Italy

ISGlobal Barcelona Institute for Global Health Barcelona Spain

KYomed INNOV Montpellier France

MASK air Montpellier France

Mauriziano Hospital Torino Italy

MEDCIDS Department of Community Medicine Information and Health Decision Sciences Faculty of Medicine University of Porto Porto Portugal

Medical Communication Consultant Medscript Ltd Dundalk Ireland and Wellington New Zealand

Medical Consulting Czarlewski Levallois France

Medical Faculty ENT Department Eskisehir Osmangazi University Eskisehir Turkey

Medical Faculty of Vilnius University Vilnius Lithuania

Medical School University of Cyprus Nicosia Cyprus

Mines ParisTech CRI PSL Research University Fontainebleau France

National Center of Expertise in Cognitive Stimulation Broca Hospital Paris France

National Heart and Lung Institute Imperial College London UK

National Heart and Lung Institute Royal Brompton Hospital and Imperial College London London UK

NIHR Imperial Biomedical Research Centre London UK

NOVA Medical School Comprehensive Health Research Centre Lisbon Portugal

Odense Research Center for Anaphylaxis Odense Denmark

Pediatric Allergy and Clinical Immunology Hospital Espanol de Mexico Mexico City Mexico

Peercode BV Geldermalsen The Netherlands

Personalized Medicine Asthma and Allergy Humanitas Clinical and Research Center IRCCS Rozzano Italy

Pneumologie AP HP Centre Université de Paris Cité Hôpital Cochin Paris France

Pneumology Unit Hospitais da Universidade de Coimbra Centro Hospitalar e Universitário de Coimbra Coimbra Portugal

PROMISE Department University of Palermo Palermo Italy

Quality Use of Respiratory Medicine Group Woolcock Institute of Medical Research The University of Sydney Sydney NSW Australia

Research Fellow OPC Cambridge UK

Respiralab Research Group Guayaquil Guayas Ecuador

Rhinology Unit and Smell Clinic ENT Department Hospital Clínic Barcelona Spain

RISE Health Research Network MEDCIDS Faculty of Medicine University of Porto Porto Portugal

Sach's Children and Youth Hospital Södersjukhuset Stockholm Sweden

School of Health Sciences Catholic University of Salta Salta Argentina

School of Medicine University CEU San Pablo Madrid Spain

Section of Rhinology and Allergy Department of Otorhinolaryngology Head and Neck Surgery University Hospital Marburg Philipps Universität Marburg Marburg Germany

Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina

Serviço de Imunoalergologia Hospital de Dona Estefânia Centro Hospitalar Universitário de Lisboa Central Lisbon Portugal

Skin and Allergy Hospital Helsinki University Hospital University of Helsinki Helsinki Finland

SOS Allergology and Clinical Immunology USL Toscana Centro Prato Italy

State Institute of Health Bavarian Health and Food Safety Authority Erlangen Germany

Sydney Local Health District Sydney NSW Australia

Terveystalo Allergy Clinic Turku Finland

UBIAir Clinical and Experimental Lung Centre and CICS UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal

UCIBIO REQUINTE Faculty of Pharmacy and Competence Center on Active and Healthy Ageing University of Porto Porto Portugal

UMR 1016 Institut Cochin Paris France

Unit of Geriatric Immunoallergology University of Bari Medical School Bari Italy

Universidad Espíritu Santo Samborondón Ecuador

Universitat Pompeu Fabra Barcelona Spain

Université Catholique de Louvain Yvoir Belgium

Université Grenoble Alpes Laboratoire HP2 Grenoble France

Université Paris Saclay UVSQ University Paris Sud Villejuif France

University Clinic of Respiratory and Allergic Diseases Golnik Slovenia

University Hospital Montpellier Montpellier France

University of Central Lancashire Medical School Preston UK

University of Liège Liège Belgium

University of Turku Turku Finland

Usher Institute The University of Edinburgh Edinburgh UK

VIM Suresnes UMR 0892 Pôle des Maladies des Voies Respiratoires Hôpital Foch Université Paris Saclay Suresnes France

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Adherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK-air Study