Lednice virus (LEDV) has been detected in Culex modestus mosquitoes in several European countries within the last six decades. In this study, phylogenetic analyses of the complete genome segments confirm that LEDV belongs to the Turlock orthobunyavirus (Orthobunyavirus, Peribunyaviridae) species and is closely related to Umbre, Turlock, and Kedah viruses.

Department of Basic Medical Sciences College of Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Building 14 Dubai Healthcare Dubai UAE

Department of Microbiology and Infectious Diseases University of Veterinary Medicine Hungária krt 23 25 1143 Budapest Hungary

Department of Virology Veterinary Research Institute Hudcova 296 621 00 Brno Czech Republic

Institute for Veterinary Medical Research Centre for Agricultural Research Hungarian Academy of Sciences Hungária krt 21 1143 Budapest Hungary

Institute of Parasitology Biology Centre of the Czech Academy of Sciences Branisovska 31 370 05 Ceske Budejovice Czech Republic

National Institute of Public Health Centre of Epidemiology and Microbiology Šrobárova 48 10042 Prague Czech Republic

Viral Zoonoses Emerging and Vector Borne Infections Group Institute of Virology University of Veterinary Medicine Vienna Veterinaerplatz 1 1210 Vienna Austria

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Danielová V., Hájková Z., Kolman J.M., Málkova D., Minár J., Smetana A. Results of the virological examination of mosquitoes in southern Moravia in 1962–1964. Cesk Epidemiol. Mikrobiol. Imunol. 1966;15:178–184. PubMed

Málková D., Danielová V., Minář J., Rosicky B., Casals J. Isolation of Yaba 1 arbovirus in Czechoslovakia. Acta Virol. 1972;16:93. PubMed

Van Regenmortel M.H.V., Fauquet C.M., Bishop D.H.L., Carstens E.B., Estes M.K., Lemon S.M., Maniloff J., Mayo M.A., McGeoch D.J., Pringle C.R., et al. Virus Taxonomy: Seventh Report of the International Committee on Taxonomy of Viruses. Academic Press; San Diego, CA, USA: 2000. p. 608.

Lefkowitz E.J., Dempsey D.M., Hendrickson R.C., Orton R.J., Siddell S.G., Smith D.B. Virus taxonomy: The database of the International Committee on Taxonomy of Viruses (ICTV) Nucleic Acids Res. 2017;46:D708–D717. doi: 10.1093/nar/gkx932. PubMed DOI PMC

Kolman J.M., Minář J., Horak I. Serologic examination of birds from the area of southern moravia for the presence of antibodies against arboviruses of the groups Alfa, Flavo, Bunyamwera Supergroup, and the virus Yaba 1-Lednice 110. 1. Domestic fowls. Zentralbl. Bakteriol. Orig. Reihe A: Med. Mikrobiol. Parasitol. 1975;23:279–287. PubMed

Wojta J., Aspöck H. Untersuchungen über die Möglichkeit der Einschleppung durch Stechmücken übertragener Arboviren durch Vögel nach Mitteleuropa. Mitt. Österr. Ges. Tropenmed. Parasitol. 1982;4:85–98.

Malková D., Danielová V., Holubová J., Marhoul Z. Less Known Arboviruses of Central Europe: A New Arbovirus Lednice. Academia Publishing House of the Czechoslovak Academy of Science; Prague, Czech Republic: 1986. p. 75.

Schwaiger K., Bauer J. Epidemiology of emerging and resurging vector-borne diseases with special attention to climate change in Germany (Review) Berl. Münch. Tierärztl. Wochenschr. 2009;122:141–160. PubMed

Málková D., Kolman J.M. Yaba 1-Lednice 110 virus proliferation in chicken embryo. Cesk. Epidemiol. Mikrobiol. Imunol. 1975;24:225–230. PubMed

Marhoul Z., Danielová V., Holubová-Krobová J., Málková D. Cultivation of Lednice (Yaba 1) virus in goose, duck, and chick embryo cells. Acta Virol. 1976;20:499–505. PubMed

Danielová V., Málková D. Studies on viremia and antibody formation in ducklings and goslings after experimental infection wih Lednice (Yaba 1) virus. Folia Parasitol. (Praha) 1976;23:367–372. PubMed

Málková D., Danielová V., Lím D. Experimental infection of black-headed gulls (Larus ridibundu L.) and coots (Fulica atra L.) with Lednice (M’Poko) virus. Folia Parasitol. (Praha) 1979;26:85–88.

Málková D., Danielová V., Viktora L., Holubová-Krobová J. Experimental infection of Macaca mulatta monkeys with Lednice (Yaba 1) virus. Acta Virol. 1976;20:226–231. PubMed

Danielová V. Relationships of Mosquitoes to Ťahyňa Virus as Determinant Factors of Its Circulation in Nature. Academia Publishing House of the Czechoslovak Academy of Sciences; Prague, Czech Republic: 1992. p. 104.

Kramer L.D., Hardy J.L., Houk E.J., Presser S.B. Characterization of the mesenteronal infection with Western equine encephalomyelitis virus in an incompetent strain of Culex tarsalis. Am. J. Trop. Med. Hyg. 1989;41:241–250. doi: 10.4269/ajtmh.1989.41.241. PubMed DOI

Reisen W.K., Hardy J.L., Reeves W.C., Presser S.B., Milby M.M., Meyer R.P. Persistence of mosquito-borne viruses in Kern County, California, 1983–1988. Am. J. Trop. Med. Hyg. 1990;43:419–437. doi: 10.4269/ajtmh.1990.43.419. PubMed DOI

Jakob W.L., Davis T., Francy D.B. Occurrence of Culex erythrothorax in southeastern Colorado and report of virus isolations from this and other mosquito species. J. Am. Mosq. Control. Assoc. 1989;5:534–536. PubMed

Yadav P.D., Chaubal G.Y., Shete A.M., Mourya D.T. A mini-review of bunyaviruses recorded in India. Indian J. Med. Res. 2017;145:601–610. PubMed PMC

Sudeep A.B., Ghodke Y.S., George R.P., Ingale V.S., Dhaigude S.D., Gokhale M.D. Vectorial capacity of Culex gelidus (Theobald) mosquitoes to certain viruses of public health importance in India. J. Vector Borne Dis. 2015;52:153–158. PubMed

Yadav P.D., Mishra A.C., Mourya D.T. Molecular characterization of Umbre virus (Bunyaviridae) Virol. J. 2008;5:115. doi: 10.1186/1743-422X-5-115. PubMed DOI PMC

Boiro I., Lomonossov N.N., Fidarov F.M., Murzine S.V., Linev N.B., Camara L.B., Bah A. Isolation of M’Poko virus (Turlock group, Bunyaviridae) from Culex cinereus mosquitoes in the Republic of Guinea. Bull. Soc. Pathol. Exot. Filiales. 1985;78:452–455. PubMed

Málková D., Danielová V., Minář J., Ryba J. Virological investigations of mosquitoes in some biotopes of southern Moravia in summer season 1972. Folia Parasitol. (Praha) 1974;21:363–372. PubMed

Mihalov-Kovács E., Martella V., Lanave G., Bodnar L., Fehér E., Marton S., Kemenesi G., Jakab F., Bányai K. Genome analysis of canine astroviruses reveals genetic heterogeneity and suggests possible inter-species transmission. Virus Res. 2017;232:162–170. doi: 10.1016/j.virusres.2016.12.005. PubMed DOI PMC

Djikeng A., Halpin R., Kuzmickas R., Depasse J., Feldblyum J., Sengamalay N., Afonso C., Zhang X., Anderson N.G., Ghedin E., et al. Viral genome sequencing by random priming methods. BMC Genom. 2008;9:5. doi: 10.1186/1471-2164-9-5. PubMed DOI PMC

Nei M., Kumar S. Molecular Evolution and Phylogenetics. Oxford University Press; New York, NY, USA: 2000.

Kumar S., Stecher G., Li M., Knyaz C., Tamura K. MEGA X: Molecular evolutionary genetics analysis across computing platforms. Mol. Biol. Evol. 2018;35:1547–1549. doi: 10.1093/molbev/msy096. PubMed DOI PMC

Shi X., Botting C.H., Li P., Niglas M., Brennan B., Shirran S.L., Szemiel A.M., Elliott R.M. Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase. Proc. Natl. Acad. Sci. USA. 2016;113:8825–8830. doi: 10.1073/pnas.1603364113. PubMed DOI PMC

Briese T., Williams D.T., Kapoor V., Diviney S.M., Certoma A., Wang J., Johansen C.A., Chowdhary R., Mackenzie J.S., Lipkin W.I., et al. Analysis of arbovirus isolates from Australia identifies novel Bunyaviruses including a Mapputta group virus from Western Australia that links Gan Gan and Maprik viruses. PLoS ONE. 2016;11:e0164868. doi: 10.1371/journal.pone.0164868. PubMed DOI PMC

Müller R., Poch O., Delarue M., Bishop D.H., Bouloy M. Rift valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerases. J. Gen. Virol. 1994;75:1345–1352. doi: 10.1099/0022-1317-75-6-1345. PubMed DOI

Reguera J., Weber F., Cusack S. Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription. PLoS Pathog. 2010;6:e1001101. doi: 10.1371/journal.ppat.1001101. PubMed DOI PMC

Blitvich B.J., Beaty B.J., Blair C.D., Brault A.C., Dobler G., Drebot M.A., Haddow A.D., Kramer L.D., LaBeaud A.D., Monath T.P., et al. Bunyavirus taxonomy: Limitations and misconceptions associated with the current ICTV criteria used for species demarcation. Am. J. Trop. Med. Hyg. 2018;99:11–16. doi: 10.4269/ajtmh.18-0038. PubMed DOI PMC

Lennette E.H., Ota M.I., Fujimoto F.Y., Wiener A., Loomis E.C. Turlock virus: A presumably new arthropod-borne virus; isolation and identification. Am. J. Trop. Med. Hyg. 1957;6:1024–1035. doi: 10.4269/ajtmh.1957.6.1024. PubMed DOI

Palya V., Kovács E.W., Marton S., Tatár-Kis T., Felföldi B., Forró B., Domán M., Bányai K. Novel orthobunyavirus causing severe kidney disease in broiler chickens, Malaysia, 2014–2017. Emerg. Infect. Dis. 2019;25:1110–1117. doi: 10.3201/eid2506.181661. PubMed DOI PMC

History of Arbovirus Research in the Czech Republic