OBJECTIVE: To investigate TNF inhibitor (TNFi) retention and response rates in European biologic-naïve patients with PsA. METHODS: Prospectively collected data on PsA patients in routine care from 12 European registries were pooled. Heterogeneity in baseline characteristics between registries were explored (analysis of variance and pairwise comparison). Retention rates (Kaplan-Meier), clinical remission [28-joint count DAS (DAS28) <2.6; 28 joint Disease Activity index for Psoriatic Arthritis ⩽4] and ACR criteria for 20% improvement (ACR20)/ACR50/ACR70 were calculated, including LUNDEX adjustment. RESULTS: Overall, 14 261 patients with PsA initiated a first TNFi. Considerable heterogeneity of baseline characteristics between registries was observed. The median 12-month retention rate (95% CI) was 77% (76, 78%), ranging from 68 to 90% across registries. Overall, DAS28/28 joint Disease Activity index for Psoriatic Arthritis remission rates at 6 months were 56%/27% (LUNDEX: 45%/22%). Six-month ACR20/50/70 responses were 53%/38%/22%, respectively. In patients initiating a first TNFi after 2009 with registered fulfilment of ClASsification for Psoriatic ARthritis (CASPAR) criteria (n = 1980) or registered one or more swollen joint at baseline (n = 5803), the retention rates and response rates were similar to those found overall. CONCLUSION: Approximately half of >14 000 patients with PsA who initiated first TNFi treatment in routine care were in DAS28 remission after 6 months, and three-quarters were still on the drug after 1 year. Considerable heterogeneity in baseline characteristics and outcomes across registries was observed. The feasibility of creating a large European database of PsA patients treated in routine care was demonstrated, offering unique opportunities for research with real-world data.

Amsterdam Rheumatology and immunology Center Academic Medical Center Amsterdam

biorx si and the Department of Rheumatology University Medical Centre Ljubljana Slovenia Ljubljana

Center of Rheumatic Diseases University of Medicine and Pharmacy Bucharest Romania

Centre for Rheumatology Research University Hospital and Faculty of Medicine University of Iceland Reykjavik Iceland

DANBIO Registry Center for Rheumatology and Spine Diseases Centre for Head and Orthopaedics Rigshospitalet Glostrup Denmark

Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

Department of Rheumatology Aarhus University Hospital Aarhus Denmark

Department of Rheumatology Amsterdam UMC VU University Medical Centre Amsterdam Amsterdam The Netherlands

Department of Rheumatology and Inflammation Research Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden

Department of Rheumatology Diakonhjemmet Hospital Oslo Norway

Department of Rheumatology Geneva University Hospital Geneva Switzerland

Epidemiology Group School of Medicine Medical Science and Nutrition University of Aberdeen Aberdeen UK

EuroSpA Coordinating Center Copenhagen Center for Arthritis Research Center for Rheumatology and Spine Diseases Centre for Head and Orthopaedics Rigshospitalet Glostrup

GISEA registry Rheumatology Unit DETO University of Bari Bari Italy

Inflammation Center Department of Rheumatology Helsinki University Hospital Helsinki Finland

Institute of Rheumatology and Department of Rheumatology 1st Faculty of Medicine Charles University Prague Czech Republic

Leitender Arzt der Universitätsklinik für Rheumatologie Immunologie und Allergologie Inselspital Bern Switzerland

Research Unit Spanish Society of Rheumatology Madrid Spain

Reuma pt registry and Instituto de Medicina Molecular Faculdade de Medicina Universidade de Lisboa Lisbon Portugal

Rheuma pt registry Rheumatology Department Centro Hospitalar do Baixo Vouga and Ibimed Institute for Biomedicine University of Aveiro Aveiro Portugal

ROB FIN Registry Helsinki University and Helsinki University Hospital Helsinki Finland

TURKBIO Registry and Division of Rheumatology School of Medicine Dokuz Eylul University Izmir Turkey

University of Iceland Faculty of Medicine and Landspitali University Hospital Reykjavik Iceland

Zitelabs Aps Copenhagen

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