Neutron Activated 153Sm Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- cancer therapy, filled carbon nanotubes, nanoencapsulation, nanooncology, nuclear imaging, radiooncology,
- MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Lung Neoplasms diagnostic imaging radiotherapy MeSH
- Nanocapsules chemistry MeSH
- Neutrons * MeSH
- Surface Properties MeSH
- Samarium chemistry MeSH
- Carbon chemistry MeSH
- Particle Size MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Nanocapsules MeSH
- Samarium MeSH
- Carbon MeSH
Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nanotubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing "cold" isotopically enriched samarium (152Sm), which can then be activated on demand to their "hot" radioactive form (153Sm) by neutron irradiation. The use of "cold" isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the "hot" nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy.
Cis Bio International Ion Beam Applications SA Gif sur Yvette 91192 France
Institut de Ciència de Materials de Barcelona Campus UAB 08193 Bellaterra Barcelona Spain
Institute of Pharmaceutical Science King's College London London SE1 9NH United Kingdom
J Heyrovsky Institute of the Physical Chemistry Dolejskova 3 182 23 Prague 8 Czech Republic
Medical Physics Laboratory University of Ioannina Medical School Ioannina 45110 Greece
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