Risk Factors in Ischemic Stroke Subtypes: A Community-Based Study in Brno, Czech Republic
Language English Country United States Media print-electronic
Document type Comparative Study, Journal Article
PubMed
31818680
DOI
10.1016/j.jstrokecerebrovasdis.2019.104503
PII: S1052-3057(19)30587-7
Knihovny.cz E-resources
- Keywords
- Czech Republic, Stroke, TOAST classification, ischemic stroke subtypes, risk factors,
- MeSH
- Time Factors MeSH
- Stroke diagnosis epidemiology MeSH
- Adult MeSH
- Brain Ischemia diagnosis epidemiology MeSH
- Comorbidity MeSH
- Middle Aged MeSH
- Humans MeSH
- Prevalence MeSH
- Patient Admission MeSH
- Registries MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Life Style * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic epidemiology MeSH
BACKGROUND: It is not known if risk factors differ between ischemic stroke (IS) subtypes in Central and Eastern Europe. AIMS: We performed a community-based analysis of risk factors in patients admitted with IS over a 1 year period in Brno, the second largest city in the Czech Republic (CR). METHODS: Based on the National Register of Hospitalized Patients, all patients with IS admitted in Brno in 2011 were identified. Comprehensive discharge summaries from hospital admissions were collected and reviewed. IS subtype and relevant risk factors were ascertained for all patients. The age- and sex-adjusted association of risk factors with IS subtypes was determined. RESULTS: Overall, 682 patients with IS were admitted in 2011 to Brno hospitals. The distribution of IS subtypes was: 35% cardioembolism, 28% large-artery atherosclerosis, 23% small-artery occlusion, 7% stroke of undetermined etiology, 7% stroke of other determined etiology. Several of the risk factors showed high prevalence in the overall sample - e.g. hypertension (84%) and hyperlipidemia (61%). Cardioembolism as compared to other subtypes was positively associated with a history of myocardial infarction, cardiac failure, and atrial fibrillation. Small-artery occlusion was positively associated with history of dementia. No significant association was found between IS subtypes and history of IS, hypertension, diabetes, obesity, alcohol abuse or smoking. CONCLUSIONS: We found high frequency of stroke risk factors in all IS subtypes. These findings have implications for stroke prevention strategies in the CR and across Central Europe.
Department of Neurology Mayo Clinic Rochester Minnesota
Institute for Health Information and Statistics of the Czech Republic Prague Czech Republic
International Clinical Research Centre St Anne's University Hospital Brno Czech Republic
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