Urinary MicroRNAs as Emerging Class of Noninvasive Biomarkers
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- Klíčová slova
- Biomarkers, MiRNA detection, MiRNA quantification, MicroRNA, Urine,
- MeSH
- analýza moči metody MeSH
- biologické markery analýza moč MeSH
- lidé MeSH
- mikro RNA analýza izolace a purifikace moč MeSH
- polymerázová řetězová reakce metody MeSH
- stabilita RNA MeSH
- urologické nemoci diagnóza moč MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- mikro RNA MeSH
MicroRNAs (miRNAs) are endogenous noncoding RNAs, which regulate gene expression on the post-transcriptional level. Since miRNAs are involved in the regulation of apoptosis, cellular proliferation, differentiation, and other important cellular processes, their deregulation is important for the development of a wide range of diseases including cancer. Apart from tissue, specific disease-related miRNA signatures can be found in body fluids as well. Especially for urologic diseases or injuries, urine miRNAs represent a promising group of biomarkers. Despite a large number of studies describing the importance of urinary miRNAs, there is a lack of recommendations for urine management and subsequent miRNA analysis. Thus, in this chapter, we aim to describe the origin and functions of urinary miRNAs and discuss the technical aspects of their detection including the pre-analytical phase principles and new directions in quantification, which could forward urine miRNA into clinical practice.
Citace poskytuje Crossref.org
