3D Patterning of cells in Magnetic Scaffolds for Tissue Engineering
Jazyk angličtina Země Velká Británie, Anglie Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
32041994
PubMed Central
PMC7010825
DOI
10.1038/s41598-020-58738-5
PII: 10.1038/s41598-020-58738-5
Knihovny.cz E-zdroje
- MeSH
- biokompatibilní materiály chemie MeSH
- biologické modely MeSH
- chemické modely MeSH
- endoteliální buňky pupečníkové žíly (lidské) fyziologie MeSH
- fyziologická neovaskularizace fyziologie MeSH
- lidé MeSH
- magnetické nanočástice chemie MeSH
- magnetické pole MeSH
- mezenchymální kmenové buňky fyziologie MeSH
- nanomedicína metody MeSH
- osteogeneze fyziologie MeSH
- ověření koncepční studie MeSH
- počítačová simulace MeSH
- regenerace kostí MeSH
- testování materiálů MeSH
- tkáňové inženýrství metody MeSH
- tkáňové podpůrné struktury chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biokompatibilní materiály MeSH
- magnetické nanočástice MeSH
A three dimensional magnetic patterning of two cell types was realised in vitro inside an additive manufactured magnetic scaffold, as a conceptual precursor for the vascularised tissue. The realisation of separate arrangements of vascular and osteoprogenitor cells, labelled with biocompatible magnetic nanoparticles, was established on the opposite sides of the scaffold fibres under the effect of non-homogeneous magnetic gradients and loading magnetic configuration. The magnetisation of the scaffold amplified the guiding effects by an additional trapping of cells due to short range magnetic forces. The mathematical modelling confirmed the strong enhancement of the magnetic gradients and their particular geometrical distribution near the fibres, defining the preferential cell positioning on the micro-scale. The manipulation of cells inside suitably designed magnetic scaffolds represents a unique solution for the assembling of cellular constructs organised in biologically adequate arrangements.
1st Moscow State Medical University Moscow Russian Federation
BioDevice Systems Praha 10 Vršovice Bulharská 996 20 Czech Republic
Humanitas Clinical and Research Center Via Manzoni 56 20089 Rozzano Milan Italy
Humanitas University Department of Biomedical Sciences Via Manzoni 113 20089 Rozzano Milano Italy
Institute for Nanostructured Materials CNR ISMN Via Gobetti 101 40129 Bologna Italy
Institute of Science and Technology for Ceramics CNR ISTEC Via Granarolo 64 48018 Faenza Italy
IRCCS Istituto Ortopedico Rizzoli Via di Barbiano 1 10 40136 Bologna Italy
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