Antitubercular nanocarrier monotherapy: Study of In Vivo efficacy and pharmacokinetics for rifampicin
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
S10 OD023524
NIH HHS - United States
PubMed
32067995
DOI
10.1016/j.jconrel.2020.02.026
PII: S0168-3659(20)30116-4
Knihovny.cz E-zdroje
- Klíčová slova
- BALB/c mice, Drug delivery system, Histopathology, Nanoparticles, Pharmacokinetics, Rifampicin, Tuberculosis,
- MeSH
- antituberkulotika MeSH
- antituberkulózní antibiotika * farmakokinetika MeSH
- Mycobacterium tuberculosis * MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- nanostruktury MeSH
- nosiče léků MeSH
- rifampin * farmakokinetika MeSH
- tuberkulóza * farmakoterapie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antituberkulotika MeSH
- antituberkulózní antibiotika * MeSH
- nosiče léků MeSH
- rifampin * MeSH
Tuberculosis represents a major global health problem for which improved approaches are needed to shorten the course of treatment and to combat the emergence of resistant strains. The development of effective and safe nanobead-based interventions can be particularly relevant for increasing the concentrations of antitubercular agents within the infected site and reducing the concentrations in the general circulation, thereby avoiding off-target toxic effects. In this work, rifampicin, a first-line antitubercular agent, was encapsulated into biocompatible and biodegradable polyester-based nanoparticles. In a well-established BALB/c mouse model of pulmonary tuberculosis, the nanoparticles provided improved pharmacokinetics and pharmacodynamics. The nanoparticles were well tolerated and much more efficient than an equivalent amount of free rifampicin.
Citace poskytuje Crossref.org
