Unrestricted use of polymer-free sirolimus eluting stents in routine clinical practice
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu klinické zkoušky, časopisecké články, pozorovací studie
PubMed
32080086
PubMed Central
PMC7034709
DOI
10.1097/md.0000000000019119
PII: 00005792-202002210-00016
Knihovny.cz E-zdroje
- MeSH
- akutní koronární syndrom diagnóza mortalita chirurgie MeSH
- antibakteriální látky terapeutické užití MeSH
- cévy - implantace protéz metody MeSH
- diabetes mellitus epidemiologie MeSH
- infarkt myokardu bez ST elevací komplikace epidemiologie MeSH
- infarkt myokardu s elevacemi ST úseků komplikace epidemiologie MeSH
- koronární angioplastika přístrojové vybavení MeSH
- lékařská praxe - způsoby provádění normy MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci koronárních tepen diagnóza mortalita chirurgie MeSH
- okluze cévního štěpu epidemiologie MeSH
- polymery MeSH
- prospektivní studie MeSH
- protézy - design MeSH
- rizikové faktory MeSH
- senioři MeSH
- sirolimus terapeutické užití MeSH
- stenty uvolňující léky škodlivé účinky trendy MeSH
- vstřebatelné implantáty škodlivé účinky MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- pozorovací studie MeSH
- Názvy látek
- antibakteriální látky MeSH
- polymery MeSH
- sirolimus MeSH
Stent designs with ultrathin struts may further increase the procedural success of challenging lesion subsets. The objective of this study was to assess the safety and efficacy of ultrathin strut, polymer-free sirolimus eluting stent (PF-SES) implantations in a large scale, unselected patient population.Adult patients underwent percutaneous coronary interventions (PCI) with a thin-strut PF-SES. Data from two all-comers observational studies having the same protocol (ClinicalTrials.gov Identifiers: NCT02629575 and NCT02905214) were pooled. The accumulated target lesion revascularization (TLR) rate at 9-12 months was the primary endpoint. All dual antiplatelet therapy strategies according to the applicable guidelines were permissible.In total, 7243 patients were prospectively enrolled for PCI with PF-SES in stable coronary artery disease or acute coronary syndrome (ACS). Major risk factors in the overall cohort were diabetes (37.3%), ST elevation myocardial infarction (18.1%) and non-ST myocardial infarction (24.6%). The follow-up rate was 88.6% in the overall population. The TLR rate in the overall cohort was 2.2% whereas definite/probable stent thrombosis (ST) occurred in 0.7%. In patients with in-stent restenosis lesions, the major adverse cardiac events rate was 6.4% whereas the corresponding rate for isolated left main coronary artery (LMCA) disease was highest with 6.7% followed by patients with culprit lesions in vein bypasses (VB, 7.1%). The mortality rate in patients treated in VB lesions was highest with 5.4%, followed by the isolated LMCA subgroup (3.4%) and ACS (2.6%).PCI with PF-SES in an unselected patient population, is associated with low clinical event and ST rates. Furthermore, PF-SES angioplasty in niche indications demonstrated favorable safety and efficacy outcomes with high procedural success rates.
Centre Hospitalier d'Avignon Avignon France
Chonnam National University Gwangju
Clinique du Millénaire Montpellier
Gachon University Gil Medical Center Incheon
Hôpital Albert Schweitzer Colmar
Hospital General Universitario de Ciudad Real Ciudad Real
Hospital Universitari Germans Trias i Pujol Badalona Spain
Hospital Universitari Vall d'Hebron
Hospital Universitario de Cruces Bilbao
Kangdong Sacred Heart Hospital South Korea
Medical Scientific Affairs B Braun France Saint Cloud France
Medical Scientific Affairs B Braun Melsungen AG Berlin Germany
Pantai Ayer Keroh Hospital Malaysia
Städtische Kliniken Esslingen Esslingen Germany
SÚSCCH a s Banská Bystrica Slovak Republic
University Hospital Královské Vinohrady Prague Czech Republic
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ClinicalTrials.gov
NCT02629575, NCT02905214