Socioeconomic characteristics of women with substance use disorder during pregnancy and neonatal outcomes in their newborns: A national registry study from the Czech Republic
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
32109712
DOI
10.1016/j.drugalcdep.2020.107933
PII: S0376-8716(20)30098-3
Knihovny.cz E-resources
- Keywords
- Growth restriction, Health registries, Neonatal outcomes, Pregnancy, Prenatal exposure, SGA, Substance use,
- MeSH
- Child MeSH
- Adult MeSH
- Infant, Small for Gestational Age physiology MeSH
- Pregnancy Complications economics epidemiology MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Birth Weight drug effects physiology MeSH
- Substance-Related Disorders economics epidemiology MeSH
- Premature Birth economics epidemiology MeSH
- Prenatal Care economics MeSH
- Registries * MeSH
- Risk Factors MeSH
- Fetal Growth Retardation economics epidemiology MeSH
- Socioeconomic Factors * MeSH
- Pregnancy MeSH
- Pregnancy Outcome economics epidemiology MeSH
- Prenatal Exposure Delayed Effects economics epidemiology MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
BACKGROUND: Maternal substance use can pose a risk to the fetal health. We studied the background characteristics of women with substance use disorders (SUDs) and selected neonatal outcomes in their children. MATERIAL AND METHODS: A database-linkage study was performed. The sample consisted of pregnant women with a SUD during pregnancy (ICD-10 diagnosis F10-F19 except F17, n = 1710), women not diagnosed with a SUD (n = 1,511,310) in Czechia in 2000-2014, and their children. The monitored neonatal outcomes were gestational age, birth weight, preterm birth, and small-for-gestational age (SGA). Binary logistic regression adjusted for age, marital status, education, concurrent substance use, and prenatal care was performed. RESULTS: Women with illicit SUDs were younger, more often unmarried, with a lower level of education, a higher abortion rate, a higher smoking rate, and lower compliance to prenatal care than women with a SUD related to alcohol, or sedatives and hypnotics (SH). Women with a SUD had worse socioeconomic situations, poorer pregnancy care, and worse neonatal outcomes than women without a SUD. After adjustment, we found no difference in SGA between the illicit SUD groups and the alcohol and the SH groups. The newborns from all SUD groups had a higher risk of SGA when compared to women without a SUD. However after adjustment, the difference remained significant just in the alcohol group (OR = 1.9, 95 % CI = 1.4-2.6). CONCLUSION: Mother's SUD during pregnancy increased risk of fetal growth restriction as measured by SGA. The role of maternal socioeconomic and lifestyle factors for the risk of SGA was substantial.
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