Socioeconomic characteristics of women with substance use disorder during pregnancy and neonatal outcomes in their newborns: A national registry study from the Czech Republic
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
32109712
DOI
10.1016/j.drugalcdep.2020.107933
PII: S0376-8716(20)30098-3
Knihovny.cz E-zdroje
- Klíčová slova
- Growth restriction, Health registries, Neonatal outcomes, Pregnancy, Prenatal exposure, SGA, Substance use,
- MeSH
- dítě MeSH
- dospělí MeSH
- hypotrofický novorozenec fyziologie MeSH
- komplikace těhotenství ekonomika epidemiologie MeSH
- lidé MeSH
- novorozenec MeSH
- porodní hmotnost účinky léků fyziologie MeSH
- poruchy spojené s užíváním psychoaktivních látek ekonomika epidemiologie MeSH
- předčasný porod ekonomika epidemiologie MeSH
- prenatální péče ekonomika MeSH
- registrace * MeSH
- rizikové faktory MeSH
- růstová retardace plodu ekonomika epidemiologie MeSH
- socioekonomické faktory * MeSH
- těhotenství MeSH
- výsledek těhotenství ekonomika epidemiologie MeSH
- zpožděný efekt prenatální expozice ekonomika epidemiologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
BACKGROUND: Maternal substance use can pose a risk to the fetal health. We studied the background characteristics of women with substance use disorders (SUDs) and selected neonatal outcomes in their children. MATERIAL AND METHODS: A database-linkage study was performed. The sample consisted of pregnant women with a SUD during pregnancy (ICD-10 diagnosis F10-F19 except F17, n = 1710), women not diagnosed with a SUD (n = 1,511,310) in Czechia in 2000-2014, and their children. The monitored neonatal outcomes were gestational age, birth weight, preterm birth, and small-for-gestational age (SGA). Binary logistic regression adjusted for age, marital status, education, concurrent substance use, and prenatal care was performed. RESULTS: Women with illicit SUDs were younger, more often unmarried, with a lower level of education, a higher abortion rate, a higher smoking rate, and lower compliance to prenatal care than women with a SUD related to alcohol, or sedatives and hypnotics (SH). Women with a SUD had worse socioeconomic situations, poorer pregnancy care, and worse neonatal outcomes than women without a SUD. After adjustment, we found no difference in SGA between the illicit SUD groups and the alcohol and the SH groups. The newborns from all SUD groups had a higher risk of SGA when compared to women without a SUD. However after adjustment, the difference remained significant just in the alcohol group (OR = 1.9, 95 % CI = 1.4-2.6). CONCLUSION: Mother's SUD during pregnancy increased risk of fetal growth restriction as measured by SGA. The role of maternal socioeconomic and lifestyle factors for the risk of SGA was substantial.
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