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Článek

Socioeconomic characteristics of women with substance use disorder during pregnancy and neonatal outcomes in their newborns: A national registry study from the Czech Republic

Mravčík, Viktor
Autor Mravčík, Viktor Department of Addictology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic National Monitoring Centre for Drugs and Addiction, Office of the Government, Prague, Czech Republic. Electronic address: viktor.mravcik@lf1.cuni.cz
Nechanská, Blanka
Autor Nechanská, Blanka Department of Addictology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic
Gabrhelík, Roman
Autor Gabrhelík, Roman Department of Addictology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
Handal, Marte
Autor Handal, Marte Norwegian Institute of Public Health, Oslo, Norway
Mahic, Milada
Autor Mahic, Milada Norwegian Institute of Public Health, Oslo, Norway
Skurtveit, Svetlana
Autor Skurtveit, Svetlana Norwegian Institute of Public Health, Oslo, Norway Norwegian Centre for Addiction Research at the University of Oslo, Norway

Drug and alcohol dependence. 2020 ; 209 (-) : 107933. [pub] 20200220

Drug Alcohol Depend
ISSN 1879-0046
Medvik
Zdroj

BACKGROUND: Maternal substance use can pose a risk to the fetal health. We studied the background characteristics of women with substance use disorders (SUDs) and selected neonatal outcomes in their children. MATERIAL AND METHODS: A database-linkage study was performed. The sample consisted of pregnant women with a SUD during pregnancy (ICD-10 diagnosis F10-F19 except F17, n = 1710), women not diagnosed with a SUD (n = 1,511,310) in Czechia in 2000-2014, and their children. The monitored neonatal outcomes were gestational age, birth weight, preterm birth, and small-for-gestational age (SGA). Binary logistic regression adjusted for age, marital status, education, concurrent substance use, and prenatal care was performed. RESULTS: Women with illicit SUDs were younger, more often unmarried, with a lower level of education, a higher abortion rate, a higher smoking rate, and lower compliance to prenatal care than women with a SUD related to alcohol, or sedatives and hypnotics (SH). Women with a SUD had worse socioeconomic situations, poorer pregnancy care, and worse neonatal outcomes than women without a SUD. After adjustment, we found no difference in SGA between the illicit SUD groups and the alcohol and the SH groups. The newborns from all SUD groups had a higher risk of SGA when compared to women without a SUD. However after adjustment, the difference remained significant just in the alcohol group (OR = 1.9, 95 % CI = 1.4-2.6). CONCLUSION: Mother's SUD during pregnancy increased risk of fetal growth restriction as measured by SGA. The role of maternal socioeconomic and lifestyle factors for the risk of SGA was substantial.