The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
32125267
DOI
10.1099/mic.0.000899
Knihovny.cz E-resources
- Keywords
- Borrelia diversity, Europe vs North America, Lyme borreliosis, genetic manipulations, tick,
- MeSH
- Biodiversity MeSH
- Borrelia burgdorferi genetics pathogenicity MeSH
- DNA, Bacterial genetics MeSH
- Virulence Factors genetics MeSH
- Genetic Variation MeSH
- Genotype MeSH
- Host-Pathogen Interactions MeSH
- Ticks microbiology MeSH
- Humans MeSH
- Lyme Disease epidemiology microbiology transmission MeSH
- Gene Expression Regulation, Bacterial * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Geographicals
- Europe MeSH
- North America MeSH
- Names of Substances
- DNA, Bacterial MeSH
- Virulence Factors MeSH
Lyme borreliosis is a vector-borne infection caused by bacteria under the Borrelia burgdorferi sensu lato complex, both in Europe and North America. Differential gene expression at different times throughout its infectious cycle allows the spirochete to survive very diverse environments within different mammalian hosts as well as the tick vector. To date, the vast majority of data about spirochetal proteins and their functions are from genetic studies carried out on North American strains of a single species, i.e. B. burgdorferi sensu stricto. The whole-genome sequences recently obtained for several European species/strains make it feasible to adapt and use genetic techniques to study inherent differences between them. This review highlights the crucial need to undertake independent studies of genospecies within Europe, given their varying genetic content and pathogenic potential, and differences in clinical manifestation.
References provided by Crossref.org
Navigating infection by pathogenic spirochetes: The host-bacteria interface at the atomic level
