The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
32125267
DOI
10.1099/mic.0.000899
Knihovny.cz E-zdroje
- Klíčová slova
- Borrelia diversity, Europe vs North America, Lyme borreliosis, genetic manipulations, tick,
- MeSH
- biodiverzita MeSH
- Borrelia burgdorferi genetika patogenita MeSH
- DNA bakterií genetika MeSH
- faktory virulence genetika MeSH
- genetická variace MeSH
- genotyp MeSH
- interakce hostitele a patogenu MeSH
- klíšťata mikrobiologie MeSH
- lidé MeSH
- lymeská nemoc epidemiologie mikrobiologie přenos MeSH
- regulace genové exprese u bakterií * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Geografické názvy
- Evropa MeSH
- Severní Amerika MeSH
- Názvy látek
- DNA bakterií MeSH
- faktory virulence MeSH
Lyme borreliosis is a vector-borne infection caused by bacteria under the Borrelia burgdorferi sensu lato complex, both in Europe and North America. Differential gene expression at different times throughout its infectious cycle allows the spirochete to survive very diverse environments within different mammalian hosts as well as the tick vector. To date, the vast majority of data about spirochetal proteins and their functions are from genetic studies carried out on North American strains of a single species, i.e. B. burgdorferi sensu stricto. The whole-genome sequences recently obtained for several European species/strains make it feasible to adapt and use genetic techniques to study inherent differences between them. This review highlights the crucial need to undertake independent studies of genospecies within Europe, given their varying genetic content and pathogenic potential, and differences in clinical manifestation.
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