Once- versus twice-weekly carfilzomib in relapsed and refractory multiple myeloma by select patient characteristics: phase 3 A.R.R.O.W. study subgroup analysis
Language English Country United States Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
32152297
PubMed Central
PMC7062899
DOI
10.1038/s41408-020-0300-y
PII: 10.1038/s41408-020-0300-y
Knihovny.cz E-resources
- MeSH
- Progression-Free Survival MeSH
- Humans MeSH
- Multiple Myeloma drug therapy mortality MeSH
- Oligopeptides pharmacology therapeutic use MeSH
- Disease Progression MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- carfilzomib MeSH Browser
- Oligopeptides MeSH
The phase 3 A.R.R.O.W. study demonstrated that treatment with once-weekly carfilzomib (70 mg/m2) and dexamethasone (once-weekly Kd70 mg/m2) improved progression-free survival compared with twice-weekly carfilzomib (27 mg/m2) and dexamethasone (twice-weekly Kd27 mg/m2) in patients with relapsed and refractory multiple myeloma (RRMM; median, 11.2 versus 7.6 months; hazard ratio [HR] = 0.69; 95% confidence interval, 0.54-0.88; P = 0.0029). Once-weekly dosing also improved response rates and depth of response. We performed a subgroup analysis from A.R.R.O.W. according to age (<65, 65-74, or ≥75 years), renal function (creatinine clearance <50, ≥50-<80, or ≥80 mL/min), number of prior therapies (2 or 3), and bortezomib-refractory status (yes or no). Compared with twice-weekly Kd27 mg/m2, once-weekly Kd70 mg/m2 reduced the risk of progression or death (HR = 0.60-0.85) and increased overall response rates in nearly all the examined subgroups, consistent with reports in the overall A.R.R.O.W. population. The safety profiles of once-weekly Kd70 mg/m2 across subgroups were also generally consistent with those in the overall population. Findings from this subgroup analysis generally demonstrate a favorable benefit-risk profile of once-weekly Kd70 mg/m2, further supporting once-weekly carfilzomib dosing as an appropriate treatment option for patients with RRMM, regardless of baseline patient and disease characteristics.
Amgen Inc Thousand Oaks CA USA
Center for Myeloma New York Presbyterian Hospital Weill Cornell Medical Center New York NY USA
Hematology Department University Hospital Hotel Dieu Nantes France
Hematology Service University Hospital Salamanca Spain
John Theurer Cancer Center at Hackensack University Medical Center Hackensack NJ USA
National and Kapodistrian University of Athens Athens Greece
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