Pathological changes in the central nervous system following exposure to ionizing radiation
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
32469226
PubMed Central
PMC8648310
DOI
10.33549/physiolres.934309
PII: 934309
Knihovny.cz E-zdroje
- MeSH
- centrální nervový systém patologie účinky záření MeSH
- ionizující záření MeSH
- kognitivní poruchy etiologie patologie MeSH
- lidé MeSH
- nádory mozku patologie radioterapie MeSH
- nemoci mozku etiologie patologie MeSH
- radiační poranění etiologie patologie MeSH
- sekundární malignity etiologie patologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Experimental studies in animals provide relevant knowledge about pathogenesis of radiation-induced injury to the central nervous system. Radiation-induced injury can alter neuronal, glial cell population, brain vasculature and may lead to molecular, cellular and functional consequences. Regarding to its fundamental role in the formation of new memories, spatial navigation and adult neurogenesis, the majority of studies have focused on the hippocampus. Most recent findings in cranial radiotherapy revealed that hippocampal avoidance prevents radiation-induced cognitive impairment of patients with brain primary tumors and metastases. However, numerous preclinical studies have shown that this problem is more complex. Regarding the fact, that the radiation-induced cognitive impairment reflects hippocampal and non-hippocampal compartments, it is highly important to investigate molecular, cellular and functional changes in different brain regions and their integration at clinically relevant doses and schedules. Here, we provide a literature review in order support the translation of preclinical findings to clinical practice and improve the physical and mental status of patients with brain tumors.
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