Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
32717439
DOI
10.1016/j.jinorgbio.2020.111160
PII: S0162-0134(20)30188-4
Knihovny.cz E-resources
- Keywords
- Anti-cancer, Apoptosis, Cobalt(II) complexes, Flufenamic acid, NSAID, Niflumic acid,
- MeSH
- Apoptosis drug effects MeSH
- Autophagy drug effects MeSH
- Phenanthrolines chemical synthesis pharmacology MeSH
- Cobalt chemistry MeSH
- Coordination Complexes chemical synthesis pharmacology MeSH
- G1 Phase Cell Cycle Checkpoints drug effects MeSH
- Flufenamic Acid analogs & derivatives pharmacology MeSH
- Humans MeSH
- Ligands MeSH
- Molecular Structure MeSH
- Cell Line, Tumor MeSH
- Antineoplastic Agents chemical synthesis pharmacology MeSH
- Drug Screening Assays, Antitumor MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- bathocuproine MeSH Browser
- Phenanthrolines MeSH
- Cobalt MeSH
- Coordination Complexes MeSH
- Flufenamic Acid MeSH
- Ligands MeSH
- Antineoplastic Agents MeSH
Two novel Co(II) fenamato complexes containing bathocuproine (bcp), namely [Co(bcp)(flu)2] (1) and [Co(bcp)(nif)2] (2) (flu = flufenamato, nif = niflumato) were synthesized and characterized by elemental analysis, single-crystal X-ray structure analysis as well as absorption and fluorescence spectroscopy. Investigation of their molecular structure revealed that both complexes are isostructural and form analogous complex molecules, with a Co(II) atom hexacoordinated by two nitrogen atoms of bcp and four oxygen atoms of two chelate bonded flu (1) and nif (2) ligands in a distorted octahedral arrangement. Surprisingly, the results of cytotoxicity experiments on four cancer cell lines (HeLa, HT-29, PC-3 and MCF-7) have revealed that despite similar structure of the complexes, the nif complex exhibits significantly higher activity, being the most effective against the PC-3 cell line (IC50 (MTT) = 6.11 ± 1.95 μM). Further studies performed on PC-3 cell line have shown that the mechanism of the cytotoxic action of nif complex (2) might involve activation of autophagic processes and apoptosis, while for its flu analogue (1) apoptosis was detected.
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