At present, a healthy diet appears to be one of the suitable strategies in slowing down cognitive decline in the process of aging. A number of evidence-based studies confirm its efficacy, safety, and cost-effectiveness. The aim of this mini review is to evaluate and describe recent randomized clinical and cohort studies exploring the effect of healthy diet on cognitive performance among healthy seniors, as well as to update the existing information on this research issue. For these reasons, the authors reviewed full-text, peer-reviewed journal articles written in English and available in Web of Science and PubMed between September 2017 and February 2020. Altogether nine original studies were detected. The results indicate that healthy diet and healthy diet components generally have a positive impact on the enhancement of cognitive functions. Furthermore, the findings reveal that dietary patterns, as well as single nutrients might have a significant effect on specific cognitive domains, such as memory in general, episodic memory, or processing speed. It also seems that a strict adherence to the dietary patterns and a higher diet variety have a more significant effect on the improvement of cognitive functions. Nevertheless, there seem to be gender differences in dietary behavior. More recently, personalized dietary interventions started to be used in delaying cognitive decline among healthy seniors. Therefore, more randomized control trials or N-of-1 trials should be performed in this research area in order to detect the most suitable dietary pattern or nutrients, which would, together with other modifiable lifestyle factors, contribute to the improvement of quality of life of the aging population.

Department of Applied Linguistics Faculty of Informatics and Management University of Hradec Králové Hradec Králové Czechia

Faculty of Engineering and Economics Wrocław University of Economics Wrocław Poland

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Akbaraly T. N., Singh-Manoux A., Dugravot A., Brunner E. J., Kivimäki M., Sabia S. (2019). Association of midlife diet with subsequent risk for dementia. PubMed PMC

Appel L. J., Moore T. J., Obarzanek E., Vollmer W. M., Svetkey L. P., Sacks F. M., et al. (1997). DASH Collaborative Research Group. A clinical trial of the effects of dietary patterns on blood pressure. PubMed

Ayaz M., Sadiq A., Junaid M., Ullah F., Ovais M., Ullah I., et al. (2019). Flavonoids as prospective neuroprotectants and their therapeutic propensity in aging associated neurological disorders. PubMed DOI PMC

Baleztena J., Ruiz-Canela M., Sayon-Orea C., Pardo M., Añorbe T., Gost J. I., et al. (2018). Association between cognitive function and supplementation with omega-3 PUFAs and other nutrients in = 75 years old patients: a randomized multicenter study. PubMed DOI PMC

Berendsen A. A. M., Kang J. H., van de Rest O., Feskens E. J. M., de Groot L. C. P. G. M., Grodstein F. (2017). The dietary approaches to stop hypertension diet, cognitive function, and cognitive decline in American older women. PubMed DOI

Calder P. C., Carding S. R., Christopher G., Kuh D., Langley-Evans S. C., McNulty H. (2018). A holistic approach to healthy ageing: how can people live longer, healthier lives? PubMed DOI

Calil S. R. B., Brucki S. M. D., Nitrini R., Yassuda M. S. (2018). Adherence to the Mediterranean and MIND diets is associated with better cognition in healthy seniors but not in MCI or AD. PubMed DOI

Chai S. C., Jerusik J., Davis K., Wright R. S., Zhang Z. (2019). Effect of Montmorency tart cherry juice on cognitive performance in older adults: a randomized controlled trial. PubMed DOI

Challa H. J., Tadi P., Uppaluri K. R. (2020).

Chen X., Maguire B., Brodaty H., O’Leary F. (2019). Dietary patterns and cognitive health in older adults: a systematic review. PubMed DOI

Cremonini A. L., Caffa I., Cea M., Nencioni A., Odetti P., Monacelli F. (2019). Nutrients in the prevention of Alzheimer’s disease. PubMed PMC

Danthiir V., Hosking D. E., Nettelbeck T., Vincent A. D., Wilson C., O’Callaghan N., et al. (2018). An 18-mo randomized, double-blind, placebo-controlled trial of DHA-rich fish oil to prevent age-related cognitive decline in cognitively normal older adults. PubMed DOI

Dinu M., Pagliai G., Casini A., Sofi F. (2017). Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials. PubMed DOI

Dodd G. F., Williams C. M., Butler L. T., Spencer J. P. E. (2019). Acute effects of flavonoid-rich blueberry on cognitive and vascular function in healthy older adults. DOI

Fard S. G., Wang F., Sinclair A. J., Elliott G., Turchini G. M. (2019). How does high DHA fish oil affect health? A systematic review of evidence. PubMed DOI

Gu Q., Sable C. M., Brooks-Wilson A., Murphy R. A. (2020). Dietary patterns in the healthy oldest old in the healthy aging study and the Canadian longitudinal study of aging: a cohort study. PubMed DOI PMC

Hosking D. E., Eramudugolla R., Cherbuin N., Anstey K. J. (2019). MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study. PubMed DOI

Karstens A. J., Tussing-Humphreys L., Zhan L., Rajendran N., Cohen J., Dion C., et al. (2019). Associations of the Mediterranean diet with cognitive and neuroimaging phenotypes of dementia in healthy older adults. PubMed DOI PMC

Kita M., Obara K., Kondo S., Umeda S., Ano Y. (2018). Effect of supplementation of a whey peptide rich in tryptophan-tyrosine-related peptides on cognitive performance in healthy adults: a randomized, double-blind, placebo-controlled study. PubMed PMC

Klimova B., Kuca K. (2018). “Chapter 22 – Multinutrient intervention in the prevention and treatment of dementia,” in DOI

Klimova B., Maresova P., Kuca K. (2016). Non-pharmacological approaches to the prevention and treatment of Alzheimer’s disease with respect to the rising treatment costs. PubMed DOI

Klimova B., Novotný M., Kuca K., Valis M. (2019). Effect of an extra-virgin olive oil intake on the delay of cognitive decline: role of secoiridoid oleuropein? PubMed DOI PMC

Klimova B., Valis M. (2018). Nutritional interventions as beneficial strategies to delay cognitive decline in healthy older individuals. PubMed DOI PMC

Knight A., Bryan J., Murphy K. (2016). Is the Mediterranean diet a feasible approach to preserving cognitive function and reducing risk of dementia for older adults in Western countries: new insights and future directions. PubMed DOI

Koch M., Jensen M. K. (2016). Association of the MIND diet with cognition and risk of Alzheimer’s disease. PubMed DOI

Krause D., Roupas P. (2017). Dietary interventions as a neuroprotective therapy for the delay of the onset of cognitive decline in older adults: evaluation of the evidence.

Kulzow N., Witte A. V., Kerti L., Grittner U., Schuchardt J. P., Hahn A., et al. (2016). Impact of omega-3 fatty acid supplementation on memory functions in healthy older adults. PubMed DOI

Kuroda Y., Matsuzaki K., Wakatsuki H., Shido O., Harauma A., Moriguchi T., et al. (2019). Influence of ultra-high hydrostatic pressurizing brown rice on cognitive functions and mental health of elderly Japanese individuals: a 2-year randomized and controlled trial. PubMed

Lehtisalo J., Ngandu T., Valve P., Antikainen R., Laatikainen T., Strandberg T., et al. (2017). Nutrient intake and dietary changes during a 2-year multi-domain lifestyle intervention among older adults: secondary analysis of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomised controlled trial. PubMed DOI

Livingston G., Sommerlad A., Orgeta V., Costafreda S. G., Huntley J., Ames D., et al. (2017). Dementia prevention, intervention, and care. PubMed

Marseglia A., Xu W., Fratiglioni L., Fabbri C., Berendsen A. A. M., Bialecka-Debek A., et al. (2018). Effect of the NU-AGE diet on cognitive functioning in older adults: a randomized controlled trial. PubMed DOI PMC

Mazza E., Fava A., Ferro Y., Rotundo S., Romeo S., Bosco D., et al. (2018). Effect of the replacement of dietary vegetable oils with a low dose of extravirgin olive oil in the Mediterranean Diet on cognitive functions in the elderly. PubMed PMC

Melby-Lervag M., Hulme C. (2016). There is no convincing evidence that working memory training is effective: a reply to Au et al. (2014) and Karbach and Verhaeghen (2014). PubMed DOI

Milte C. M., Ball K., Crawford D., McNaughton S. A. (2019). Diet quality and cognitive function in mid-aged and older men and women. PubMed DOI PMC

Moran C., Scotto di Palumbo A., Bramham J., Moran A., Rooney B., De Vito G., et al. (2018). Effects of a six-month multi-ingredient nutrition supplement intervention of omega-3 polyunsaturated fatty acids, vitamin d, resveratrol, and whey protein on cognitive function in older adults: a randomised, double-blind, controlled trial. PubMed

Moris M. C. (2016). Nutrition and risk of dementia: overview and methodological issues. PubMed DOI PMC

Morris M. C., Booth S. L., Dawson-Hughes B., Barnes L. L., Bennett D. A., Wang Y. (2015a). Relations to cognitive change with age of micronutrients found in green leafy vegetables.

Morris M. C., Tangney C. C., Wang Y., Sacks F. M., Barnes L. L., Bennett D. A., et al. (2015b). MIND diet slows cognitive decline with aging. PubMed DOI PMC

Mumme K. D., von Hurst P. R., Conlon C. A., Jones B., Haskell-Ramsay C. F., Stonehouse W., et al. (2019). Study protocol: associations between dietary patterns, cognitive function and metabolic syndrome in older adults - a cross-sectional study. PubMed DOI PMC

Okubo H., Inagaki H., Gondo Y., Kamide K., Ikebe K., Masui Y., et al. (2017). Association between dietary patterns and cognitive function among 70-year-old Japanese elderly: a cross-sectional analysis of the SONIC study. PubMed PMC

Rakesh G., Szabo S. T., Alexopoulos G. S., Zannas A. S. (2017). Strategies for dementia prevention: latest evidence and implications. PubMed DOI PMC

Rosenberg A., Ngandu T., Rusanen M., Antikainen R., Bäckman L., Havulinna S., et al. (2018). Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: the FINGER trial. PubMed DOI

Scarmeas N., Anastasiou C. A., Yannakoulia M. (2018). Nutrition and prevention of cognitive impairment. PubMed DOI

Scarmeas N., Stern N., Tang M. X., Mayeux R., Luchsinger J. A. (2006). Mediterranean diet and risk for Alzheimer’s disease. PubMed PMC

Scott T. M., Rasmussen H. M., Chen O., Johnson E. J. (2017). Avocado consumption increases macular pigment density in older adults: a randomized, controlled trial. PubMed DOI PMC

Smyth A., Dehghan M., O’Donnell M., Anderson C., Teo K., Gao P., et al. (2015). Healthy eating and reduced risk of cognitive decline: a cohort from 40 countries. PubMed DOI PMC

Soldevila-Domenech N., Boronat A., Langohr K., de la Torre R. (2019). N-of-1 clinical trials in nutritional interventions directed at improving cognitive function. PubMed DOI PMC

Solfrizzi V., Agosti P., Lozupone M., Custodero C., Schilardi A., Valiani V., et al. (2018). Nutritional intervention as a preventive approach for cognitive-related outcomes in cognitively healthy older adults: a systematic review. PubMed

Steinberg D., Bennett G. G., Svetkey L. (2017). The DASH diet, 20 years later. PubMed PMC

Tangney C. C., Li H., Wang Y., Barnes L., Schneider J. A., Bennett D. A., et al. (2014). Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. PubMed DOI PMC

van de Rest O., Geleijnse J. M., Kok F. J., van Staveren W. A., Dullemeijer C., Olderikkert M. G., et al. (2008). Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. PubMed DOI

van den Brink A. C., Brouwer-Brolsma E. M., Berendsen A. A. M., van de Rest O. (2019). The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets are associated with less cognitive decline and a lower risk of Alzheimer’s disease-a review. PubMed DOI PMC

Vanoh D., Ishak I. H., Shahar S., Manaf Z. A., Ali N. M., Noah S. A. M. (2018). Development and assessment of a web-based intervention for educating older people on strategies promoting healthy cognition. PubMed DOI PMC

Vauzour D., Camprubi-Robles M., Miquel-Kergoat S., Andres-Lacueva C., Bánáti D., Barberger-Gateau P., et al. (2017). Nutrition for the ageing brain: towards evidence for an optimal diet. PubMed DOI

WHO (2020).

Whyte A. R., Cheng N., Fromentin E., Williams C. M. (2018). A randomized, double-blinded, placebo-controlled study to compare the safety and efficacy of low dose enhanced wild blueberry powder and wild blueberry extract (ThinkBlue PubMed PMC

Willett W. C., Sacks F., Trichopoulou A., Ferro-Luzzi A., Helsing E., Trichopoulos D. (1995). Mediterranean diet pyramid: a cultural model for healthy eating. PubMed

Wright R. S., Waldstein S. R., Kuczmarski M. F., Pohlig R. T., Gerassimakis C. S., Gaynor B., et al. (2017). Diet quality and cognitive function in an urban sample: findings from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. PubMed DOI PMC