Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients
Jazyk angličtina Země Řecko Médium print-electronic
Typ dokumentu časopisecké články, pozorovací studie
PubMed
33000239
DOI
10.3892/or.2020.7774
Knihovny.cz E-zdroje
- Klíčová slova
- structural chromosomal aberrations, telomere length, peripheral blood lymphocytes, breast cancer, colorectal cancer, lung cancer, cancer susceptibility, patient long‑term survival,
- MeSH
- chromozomální aberace * MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokální recidiva nádoru epidemiologie genetika MeSH
- lymfocyty metabolismus MeSH
- nádory krev genetika mortalita MeSH
- následné studie MeSH
- nestabilita genomu MeSH
- přežití bez známek nemoci MeSH
- prognóza MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- telomerasa MeSH
- telomery metabolismus MeSH
- zkracování telomer MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- Názvy látek
- telomerasa MeSH
Accumulation of non‑specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer‑free control individuals were investigated. These results were then correlated with clinicopathological factors and follow‑up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid‑type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer.
Biomedical Centre Faculty of Medicine in Pilsen Charles University Pilsen 323 00 Czech Republic
Department of Oncosurgery Medicon Prague 140 00 Czech Republic
Department of Surgery Faculty Hospital Kralovske Vinohrady Prague 100 34 Czech Republic
Division of Molecular Genetic Epidemiology German Cancer Research Center Heidelberg 691 20 Germany
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