AIM: Due to mandatory vaccination introduced in the Czech Republic since 1969, only few measles cases were reported annually until recently. However, a rapid increase of cases has been recorded in last two years. In contrast to the pre-vaccination era, in recent measles outbreaks, many cases have been reported among vaccinated adults. Health care workers (HCWs) are particularly at high risk of contact with measles. Therefore, to minimize transmission in health care settings, many hospitals evaluate measles immune status of their HCWs and offer free vaccination to those with too low anti-measles antibody levels. The aim of this study was to evaluate the seroprevalence of IgG antibodies against measles in all HCWs of the Strakonice Hospital. MATERIALS AND METHODS: Anti-measles IgG serum levels were measured using quantitative ELISA. RESULTS: Almost all HCWs born before 1969, when the mandatory vaccination started, showed high levels of IgG antibodies (93.5%). Contrarily, among previously vaccinated individuals, only 64.8% were seropositive. A high percentage of seronegative or borderline samples was observed even in the age groups who were previously vaccinated with two doses. CONCLUSIONS: In total, 25.4% of all HCWs of the Strakonice Hospital had too low anti-measles IgG levels, and most of them were immunized with one dose of MMR vaccine. Prioritized vaccination substantially decreased the number of staff at higher risk of measles acquisition and, at the same time, of those who would need to be quarantined after exposure.

Seroprevalence of Measles Antibodies in the Population of the Olomouc Region, Czech Republic-Comparison of the Results of Four Laboratories