Src kinase: Key effector in mechanosignalling
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
33359015
DOI
10.1016/j.biocel.2020.105908
PII: S1357-2725(20)30225-9
Knihovny.cz E-resources
- Keywords
- Cytoskeleton, Integrins, Mechanosensing, Src, YAP, p130Cas,
- MeSH
- Adaptor Proteins, Signal Transducing genetics metabolism MeSH
- Mechanotransduction, Cellular genetics MeSH
- Cytoskeleton metabolism pathology ultrastructure MeSH
- Extracellular Matrix metabolism pathology ultrastructure MeSH
- Integrins genetics metabolism MeSH
- Humans MeSH
- Stress, Mechanical MeSH
- Neoplasms genetics metabolism pathology MeSH
- Protein Serine-Threonine Kinases genetics metabolism MeSH
- Gene Expression Regulation MeSH
- Hippo Signaling Pathway MeSH
- YAP-Signaling Proteins MeSH
- src-Family Kinases genetics metabolism MeSH
- Crk-Associated Substrate Protein genetics metabolism MeSH
- Transcription Factors genetics metabolism MeSH
- Receptor-Like Protein Tyrosine Phosphatases, Class 4 genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Adaptor Proteins, Signal Transducing MeSH
- BCAR1 protein, human MeSH Browser
- Integrins MeSH
- Protein Serine-Threonine Kinases MeSH
- PTPRA protein, human MeSH Browser
- YAP-Signaling Proteins MeSH
- src-Family Kinases MeSH
- Crk-Associated Substrate Protein MeSH
- Transcription Factors MeSH
- Receptor-Like Protein Tyrosine Phosphatases, Class 4 MeSH
- YAP1 protein, human MeSH Browser
Cells have developed a unique set of molecular mechanisms that allows them to probe mechanical properties of the surrounding environment. These systems are based on deformable primary mechanosensors coupled to tension transmitting proteins and enzymes generating biochemical signals. This modular setup enables to transform a mechanical load into more versatile biochemical information. Src kinase appears to be one of the central components of the mechanotransduction network mediating force-induced signalling across multiple cellular contexts. In tight cooperation with primary sensors and the cytoskeleton, Src functions as an effector molecule necessary for transformation of mechanical stimuli into biochemical outputs executing cellular response and adaptation to mechanical cues.
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