Fumonisin B1: Mechanisms of toxicity and biological detoxification progress in animals
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Review
PubMed
33428988
DOI
10.1016/j.fct.2021.111977
PII: S0278-6915(21)00011-9
Knihovny.cz E-resources
- Keywords
- Apoptosis, Autophagy, Fumonisin B1, Immunotoxicity, Joint toxicity, Reproductive toxicity,
- MeSH
- Apoptosis drug effects MeSH
- Fumonisins chemistry metabolism toxicity MeSH
- Fusarium metabolism MeSH
- Food Contamination * MeSH
- Animal Feed analysis MeSH
- Oxidative Stress drug effects MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- fumonisin B1 MeSH Browser
- Fumonisins MeSH
Fumonisin B1 (FB1) is a toxic secondary metabolite produced by the Fusarium molds that can contaminate food and feed. It has been found that FB1 can cause systemic toxicity, including neurotoxicity, hepatotoxicity, nephrotoxicity and mammalian cytotoxicity. This review addresses the toxicity studies carried out on FB1 and outlines the probable mechanisms underlying its immunotoxicity, reproductive toxicity, joint toxicity, apoptosis, and autophagy. In the present work, the research progress of FB1 detoxification in recent years is reviewed, which provides reference for controlling and reducing the toxicity of FB1.
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