Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
33609963
DOI
10.1016/j.parkreldis.2021.02.012
PII: S1353-8020(21)00053-5
Knihovny.cz E-resources
- Keywords
- Acoustic analysis, Hypokinetic dysarthria, Parkinson's disease, Resting-state functional connectivity, Voxel-based morphometry, fMRI,
- MeSH
- Speech Acoustics * MeSH
- Dysarthria * diagnosis etiology pathology physiopathology MeSH
- Connectome * MeSH
- Humans MeSH
- Magnetic Resonance Imaging * MeSH
- Multimodal Imaging MeSH
- Nerve Net * diagnostic imaging pathology physiopathology MeSH
- Parkinson Disease * complications diagnostic imaging pathology physiopathology MeSH
- Gray Matter * diagnostic imaging pathology physiopathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Temporal Lobe * diagnostic imaging pathology physiopathology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
INTRODUCTION: Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech. METHODS: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed. RESULTS: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control. CONCLUSIONS: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.
Department of Neurology College of Medicine University of Arizona Tucson USA
Department of Telecommunications Brno University of Technology Brno Czech Republic
References provided by Crossref.org
Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study
Language impairment in Parkinson's disease: fMRI study of sentence reading comprehension
