Hyaluronan and its derivatives for ophthalmology: Recent advances and future perspectives
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
33673986
DOI
10.1016/j.carbpol.2021.117697
PII: S0144-8617(21)00084-9
Knihovny.cz E-zdroje
- Klíčová slova
- Amphiphilic derivatives, Complexation, Dry eye disease, Hyaluronan, Medical devices, Ophthalmology,
- MeSH
- antitumorózní látky chemie metabolismus MeSH
- glaukom farmakoterapie MeSH
- kyselina hyaluronová analogy a deriváty terapeutické užití MeSH
- lidé MeSH
- nosiče léků chemie MeSH
- oční nemoci farmakoterapie MeSH
- oční roztoky chemie MeSH
- viskozita MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- antitumorózní látky MeSH
- kyselina hyaluronová MeSH
- nosiče léků MeSH
- oční roztoky MeSH
Ophthalmic disorders are amid the most common pathologies worldwide. In this regard, hyaluronan (HA) has gained widespread use in eye surgeries and treatment of eye diseases. HA-based materials are well tolerated and show excellent biocompatibility. Therefore, HA is a sought-after component of ophthalmic formulations. However, several parameters have to be adjusted to reach an optimal performance and effectiveness. The complexity of HA properties represents a major challenge for biological and structural characterization. This review covers fundamental aspects and recent developments in HA ophthalmic research. Biological mechanisms underlying the health benefits of HA and their potential therapeutic applications are elaborated. Furthermore, current pharmacokinetic and safety studies are discussed. Noticeably, the benefits of chemical modification and processed HA forms are described to broaden the applications of this unique polysaccharide. The current research challenges and prospects are also outlined and discussed.
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