Renal cell carcinomas with tubulopapillary architecture and oncocytic cells: Molecular analysis of 39 difficult tumors to classify
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
33838490
DOI
10.1016/j.anndiagpath.2021.151734
PII: S1092-9134(21)00034-4
Knihovny.cz E-resources
- Keywords
- Copy number variation pattern, Kidney, Oncocytic renal cell carcinoma, Oncocytoma, Overlapping, Papillary, Unclassified,
- MeSH
- Biopsy, Large-Core Needle standards MeSH
- Chromosome Aberrations MeSH
- Diagnostic Errors MeSH
- Diagnosis, Differential MeSH
- Adult MeSH
- In Situ Hybridization, Fluorescence methods MeSH
- Immunohistochemistry methods MeSH
- Carcinoma, Renal Cell epidemiology genetics pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Biomarkers, Tumor metabolism MeSH
- Kidney Neoplasms diagnosis genetics pathology MeSH
- Adenoma, Oxyphilic diagnosis genetics pathology MeSH
- Oxyphil Cells metabolism pathology MeSH
- Genes, Overlapping genetics MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Neoplasm Staging methods MeSH
- DNA Copy Number Variations genetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
So-called oncocytic papillary renal cell carcinoma (OPRCC) is a poorly defined variant of papillary renal cell carcinoma. Since its first description, several studies were published with conflicting results, and thus precise definition is lacking. A cohort of 39 PRCCs composed of oncocytic cells were analyzed. Cases were divided into 3 groups based on copy number variation (CNV) pattern. The first group consisted of 23 cases with CNV equal to renal oncocytoma. The second group consisted of 7 cases with polysomy of chromosomes 7 and 17 and the last group of 9 cases included those with variable CNV. Epidemiologic, morphologic and immunohistochemical features varied among the groups. There were not any particular histomorphologic features correlating with any of the genetic subgroups. Further, a combination of morphologic, immunohistochemical, and molecular-genetic features did not allow to precisely predict biologic behavior. Owing to variable CNV pattern in OPRCC, strict adherence to morphology and immunohistochemical profile is recommended, particularly in limited samples (i.e., core biopsy). Applying CNV pattern as a part of a diagnostic algorithm can be potentially misleading. OPRCC is a highly variable group of tumors, which might be misdiagnosed as renal oncocytoma. Using the term OPRCC as a distinct diagnostic entity is, thanks to its high heterogeneity, questionable.
Department of Pathology Charles University Prague Faculty of Medicine in Plzeň Pilsen Czech Republic
Department of Pathology Institute Nacional de Cancerologia Mexico City Mexico
Department of Pathology Stradin's University Riga Latvia
Department of Urology Charles University Prague Faculty of Medicine in Plzeň Pilsen Czech Republic
References provided by Crossref.org
Acceptance of emerging renal oncocytic neoplasms: a survey of urologic pathologists
