Serotype-specific surveillance for invasive pneumococcal disease (IPD) is essential for assessing the impact of 10- and 13-valent pneumococcal conjugate vaccines (PCV10/13). The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project aimed to evaluate the global evidence to estimate the impact of PCV10/13 by age, product, schedule, and syndrome. Here we systematically characterize and summarize the global landscape of routine serotype-specific IPD surveillance in PCV10/13-using countries and describe the subset that are included in PSERENADE. Of 138 countries using PCV10/13 as of 2018, we identified 109 with IPD surveillance systems, 76 of which met PSERENADE data collection eligibility criteria. PSERENADE received data from most (n = 63, 82.9%), yielding 240,639 post-PCV10/13 introduction IPD cases. Pediatric and adult surveillance was represented from all geographic regions but was limited from lower income and high-burden countries. In PSERENADE, 18 sites evaluated PCV10, 42 PCV13, and 17 both; 17 sites used a 3 + 0 schedule, 38 used 2 + 1, 13 used 3 + 1, and 9 used mixed schedules. With such a sizeable and generally representative dataset, PSERENADE will be able to conduct robust analyses to estimate PCV impact and inform policy at national and global levels regarding adult immunization, schedule, and product choice, including for higher valency PCVs on the horizon.

Arctic Investigations Program Division of Preparedness and Emerging Infections National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Anchorage AK 99508 USA

Bacterial Respiratory Infection Service Scottish Microbiology Reference Laboratory NHS GG and C Glasgow G31 2ER UK

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Child Health Research Foundation Dhaka 1207 Bangladesh

CIBER Epidemiología y Salud Pública 28029 Madrid Spain

Communicable Diseases Centre National Institute of Public Health 1000 Ljubljana Slovenia

Department of Clinical Microbiology Landspitali The National University Hospital Hringbraut 101 Reykjavik Iceland

Department of Communicable Disease and Control and Health Protection Public Health Agency of Sweden 171 82 Solna Sweden

Department of Health Security Finnish Institute for Health and Welfare 00271 Helsinki Finland

Department of Infection Control and Vaccine Norwegian Institute of Public Health 0456 Oslo Norway

Department of Infectious Diseases Italian National Institute of Health 00161 Rome Italy

Department of Medical Microbiology Medical University of Sofia Faculty of Medicine 1431 Sofia Bulgaria

Department of Microbiology and Carol Yu Centre for Infection Queen Mary Hospital The University of Hong Kong Hong Kong China

Department of Microbiology Faculty of Medicine and Pharmacy Hassan 2 University of Casablanca Casablanca 20000 Morocco

Department of Microbiology Immunology and Transplantation KU Leuven 3000 Leuven Belgium

Department of Pediatrics University of Calgary and Alberta Health Services Calgary AB T3B 6A8 Canada

Department of Pediatrics Yale New Haven Children's Hospital New Haven CT 06504 USA

Department of Social and Preventive Medicine Laval University Québec QC G1V 0A6 Canada

Division of Pediatric Infectious Diseases Department of Pediatrics University of Utah Health Sciences Center Salt Lake City UT 84132 USA

Doctoral Studies Department Riga Stradinš University 1007 Riga Latvia

Epidemiology and Demography Department KEMRI Wellcome Trust Research Programme Centre for Geographic Medicine Coast P O Box 230 80108 Kilifi Kenya

Epidemiology Department Dirección General de Salud Pública 28009 Madrid Spain

Epidemiology Department Epiconcept 75012 Paris France

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European Centre for Disease Prevention and Control 169 73 Solna Sweden

Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine Keppel St London WC1E 7HT UK

Health Sciences Unit Faculty of Social Sciences Tampere University 33100 Tampere Finland

Immunisation and Countermeasures Division Public Health England London NW9 5EQ UK

Independent Consultant 1296 Coppet Switzerland

Infectious Disease Epidemiology and Prevention Statens Serum Institut DK 2300 Copenhagen Denmark

Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud Tres Ríos 30301 Cartago Costa Rica

Instituto de Salud Pública de Chile Santiago 7780050 Santiago Metropolitan Chile

Instituto de Salud Pública de Navarra IdiSNA 31003 Pamplona Spain

Irish Meningitis and Sepsis Reference Laboratory Children's Health Ireland at Temple Street Temple Street D01 YC76 Dublin 1 Ireland

Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA

Laboratorio Central de Salud Pública Asunción Paraguay Asunción Paraguay

Malawi Liverpool Wellcome Trust Clinical Research Programme P O Box 30096 Chichiri Blantyre Malawi

Medical Research Council Unit the Gambia at London School of Hygiene and Tropical Medicine P O Box 273 Banjul The Gambia

Ministry of Health and Medical Services Suva Fiji

National Center for Immunizations and Respiratory Diseases Centers for Disease Control and Prevention Atlanta GA 30333 USA

National Center of Communicable Diseases Ministry of Health Bayanzurkh District Ulaanbaatar 13336 Mongolia

National Centre for Immunisation Research and Surveillance and Discipline of Child and Adolescent Health Children's Hospital Westmead Clinical School Faculty of Medicine and Health University of Sydney Westmead NSW 2145 Australia

National Institute for Public Health and the Environment 3721 MA Bilthoven The Netherlands

National Institute of Public Health 100 42 Praha Czech Republic

National Laboratory for Meningitis and Pneumococcal Infections Center of Bacteriology Institute Adolfo Lutz São Paulo 01246 902 Brazil

National Public Health Organisation 15123 Athens Greece

National Reference Center for Streptococci Department of Medical Microbiology University Hospital RWTH Aachen 52074 Aachen Germany

National Reference Centre for Bacterial Meningitis National Medicines Institute 00 725 Warsaw Poland

National Reference Centre for Pneumococcal and Haemophilus Diseases Regional Authority of Public Health 975 56 Banská Bystrica Slovakia

National Reference Centre for Streptococcus Pneumoniae University Hospitals Leuven 3000 Leuven Belgium

New Vaccines Group Murdoch Children's Research Institute Parkville Melbourne VIC 3052 Australia

NIHR Global Health Research Unit on Mucosal Pathogens Division of Infection and Immunity UCL Bloomsbury London WC1E 6BT UK

Pan American Health Organization World Health Organization Washington DC 20037 USA

Santé Publique France the French National Public Health Agency FR 94410 Saint Maurice France

School of Pathology Faculty of Health Sciences University of the Witwatersrand Braamfontein Johannesburg 2000 South Africa

School of Public Health Faculty of Health Sciences University of the Witwatersrand Braamfontein Johannesburg 2000 South Africa

Servicio de Bacteriología Clínica Departamento de Bacteriología INEI ANLIS Dr Carlos G Malbrán Buenos Aires C1282 AFF Argentina

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Surveillance and Public Health Emergency Response Public Health Agency of Catalonia 08005 Barcelona Spain

Swiss National Reference Centre for invasive Pneumococci Institute for Infectious Diseases University of Bern 3012 Bern Switzerland

The Faculty of Health Sciences Ben Gurion University of the Negev 8410501 Beer Sheva Israel

Toronto Invasive Bacterial Diseases Network and Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON M5S 1A8 Canada

Toyama Institute of Health Imizu Toyama 939 0363 Japan

Vaccine Study Center Kaiser Permanente Oakland CA 94612 USA

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Global impact of ten-valent and 13-valent pneumococcal conjugate vaccines on invasive pneumococcal disease in all ages (the PSERENADE project): a global surveillance analysis

Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project